Publikationen der AG Molekulare Psychopharmakologie

Pub_links

http://www.ncbi.nlm.nih.gov/pubmed/?term=nothdurfter+c

Ausgewählte Publikationen

Brunner LM, Maurer F, Weber K, Weigl J, Milenkovic VM, Rupprecht R, Nothdurfter C, Mühlberger A.Differential effects of the translocator protein 18 kDa (TSPO) ligand etifoxine and the benzodiazepine alprazolam on startle response to predictable threat in a NPU-threat task after acute and short-term treatment. Psychopharmacology (Berl). 2022 Jul;239(7):2233-2244. doi: 10.1007/s00213-022-06111-x. Epub 2022 Mar 12. PMID: 35278124
Bauer O, Milenkovic VM, Hilbert S, Sarubin N, Weigl J, Bahr LM, Wetter TC, Heckel B, Wetzel CH, Rupprecht R, Nothdurfter C.Association of Chemokine (C-C Motif) Receptor 5 and Ligand 5 with Recovery from Major Depressive Disorder and Related Neurocognitive Impairment. Neuroimmunomodulation. 2020;27(3):152-162. doi: 10.1159/000513093. Epub 2021 Jan 27. PMID: 33503626
Bahr LM, Maurer F, Weigl J, Weber K, Melchner D, Dörfelt A, Wechsler TF, Bauer O, Reinders J, Milenkovic VM, Wetzel CH, Wetter TC, Rupprecht R, Mühlberger A, Nothdurfter C. Dissociation of endocrine responses to the Trier Social Stress Test in Virtual Reality (VR-TSST) by the benzodiazepine alprazolam and the translocator protein 18 kDa (TSPO) ligand etifoxine. Psychoneuroendocrinology. 2021 Feb;124:105100. doi: 10.1016/j.psyneuen.2020.105100. Epub 2020 Dec 5.
Sarubin N, Hilbert S, Naumann F, Zill P, Wimmer AM, Nothdurfter C, Rupprecht R, Baghai TC, Bühner M, Schüle C. The sex-dependent role of the glucocorticoid receptor in depression: variations in the NR3C1 gene are associated with major depressive disorder in women but not in men. Eur Arch Psychiatry Clin Neurosci. 2017;267:123-133.

Nothdurfter C, Milenkovic VM, Sarubin N, Hilbert S, Manook A, Weigl J, Almeqbaali K, Wetzel CH, Rupprecht R, Baghai TC. The cytokine IL-17A as a marker of treatment resistance in major depressive disorder? Eur J Neurosci. 2019 Dec 2. doi: 10.1111/ejn.14636. Online ahead of print.

Baghai TC, Varallo-Bedarida G, Born C, Häfner S, Schüle C, Eser D, Zill P, Manook A, Weigl J, Jooyandeh S, Nothdurfter C, von Schacky C, Bondy B, Rupprecht R. Classical Risk Factors and Inflammatory Biomarkers: One of the Missing Biological Links between Cardiovascular Disease and Major Depressive Disorder. Int J Mol Sci. 2018 Jun 12;19(6).

Bader S, Wolf L, Milenkovic VM, Gruber M, Nothdurfter C, Rupprecht R, Wetzel CH. Differential effects of TSPO ligands on mitochondrial function in mouse microglia cells. Psychoneuroendocrinology. 2019;106:65-76.

Milenkovic VM, Slim D, Bader S, Koch V, Heinl ES, Alvarez-Carbonell D, Nothdurfter C, Rupprecht R, Wetzel CH. CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells. Int J Mol Sci. 2019;20(13):3359.

Kuffner K, Triebelhorn J, Meindl K, Benner C, Manook A, Sudria-Lopez D, Siebert R, Nothdurfter C, Baghai TC, Drexler K, Berneburg M, Rupprecht R, Milenkovic VM, Wetzel CH. Major Depressive Disorder is Associated with Impaired Mitochondrial Function in Skin Fibroblasts. Cells. 2020;9(4):884.

Milenkovic VM, Bader S, Sudria-Lopez D, Siebert R, Brandl C, Nothdurfter C, Weber BHF, Rupprecht R, Wetzel CH. Effects of genetic variants in the TSPO gene on protein structure and stability. PLoS One. 2018 Apr 11;13(4):e0195627. PMID: 29641545 Free PMC Article
Milenkovic VM, Sarubin N, Hilbert S, Baghai TC, Stöffler F, Lima-Ojeda JM, Manook A, Almeqbaali K, Wetzel CH, Rupprecht R, Nothdurfter C. Macrophage-Derived Chemokine: A Putative Marker of Pharmacological Therapy Response in Major Depression? Neuroimmunomodulation. 2017;24(2):106-112. doi: 10.1159/000479739. Epub 2017 Sep 13. PMID: 28898872
Sarubin N, Baghai TC, Lima-Ojeda JM, Melchner D, Hallof-Buestrich H, Wolf L, Hilbert S, Milenkovic VM, Wetzel CH, Rupprecht R, Nothdurfter C. Translocator Protein (TSPO) Expression in Platelets of Depressed Patients Decreases during Antidepressant Therapy. Pharmacopsychiatry. 2016 Sep;49(5):204-209. PMID: 27276366
Wolf L, Bauer A, Melchner D, Hallof-Buestrich H, Stoertebecker P, Haen E, Kreutz M, Sarubin N, Milenkovic VM, Wetzel CH, Rupprecht R, Nothdurfter C. Enhancing neurosteroid synthesis--relationship to the pharmacology of translocator protein (18 kDa) (TSPO) ligands and benzodiazepines. Pharmacopsychiatry. 2015 Mar;48(2):72-7. doi: 10.1055/s-0034-1398507. PMID: 25654303
Nothdurfter C, Schmotz C, Sarubin N, Baghai TC, Laenger A, Lieb M, Bondy B, Rupprecht R, Schüle C. Effects of escitalopram/quetiapine combination therapy versus escitalopram monotherapy on hypothalamic-pituitary-adrenal-axis activity in relation to antidepressant effectiveness. J Psychiatr Res. 2014 May;52:15-20. doi: 10.1016/j.jpsychires.2014.01.013.PMID: 24513501
Nothdurfter C, Tanasic S, Di Benedetto B, Uhr M, Wagner EM, Gilling KE, Parsons CG, Rein T, Holsboer F, Rupprecht R, Rammes G. Lipid raft integrity affects GABAA receptor, but not NMDA receptor modulation by psychopharmacological compounds. Int J Neuropsychopharmacol. 2012 Dec 10:1-11. [Epub ahead of print] PMID: 23217923
Nothdurfter C, Baghai TC, Schüle C, Rupprecht R. Translocator protein (18 kDa) (TSPO) as a therapeutic target for anxiety and neurologic disorders. Eur Arch Psychiatry Clin Neurosci. 2012 Nov;262 Suppl 2:S107-12. doi: 10.1007/s00406-012-0352-5. Epub 2012 Aug 26. Review. PMID: 22923187
Nothdurfter C, Giegling I, Konte B, Hartmann AM, Konnerth H, Friedl M, Rammes G, Rupprecht R, Rujescu D. Lack of association of the 5-HT(3A) receptor with schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2012 Apr;159B(3):310-5. doi: 10.1002/ajmg.b.32028. Epub 2012 Feb 10. PMID: 22328445
Nothdurfter C, Rupprecht R, Rammes G. Recent developments in potential anxiolytic agents targeting GABAA/BzR complex or the translocator protein (18kDa) (TSPO). Curr Top Med Chem. 2012;12(4):360-70. Review. PMID: 22204486
Di Benedetto B, Kühn R, Nothdurfter C, Rein T, Wurst W, Rupprecht R. N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant. Neuropharmacology. 2012 Jan;62(1):209-16. doi: 10.1016/j.neuropharm.2011.07.001. Epub 2011 Jul 13. PMID: 21767553
Nothdurfter C, Rammes G, Baghai TC, Schüle C, Schumacher M, Papadopoulos V, Rupprecht R. Translocator protein (18 kDa) as a target for novel anxiolytics with a favourable side-effect profile. J Neuroendocrinol. 2012 Jan;24(1):82-92. doi: 10.1111/j.1365-2826.2011.02166.x. Review. PMID: 21609361
Nothdurfter C, Tanasic S, Rammes G, Rupprecht R. Modulation of ligand-gated ion channels as a novel pharmacological principle. Pharmacopsychiatry. 2011 May;44 Suppl 1:S27-34. doi: 10.1055/s-0031-1271704. Epub 2011 May 4. PMID: 21544743
Schüle C, Eser D, Baghai TC, Nothdurfter C, Kessler JS, Rupprecht R. Neuroactive steroids in affective disorders: target for novel antidepressant or anxiolytic drugs? Neuroscience. 2011 Sep 15;191:55-77. doi: 10.1016/j.neuroscience.2011.03.025. Epub 2011 Mar 23. Review. PMID: 21439354
Nothdurfter C, Tanasic S, Di Benedetto B, Rammes G, Wagner EM, Kirmeier T, Ganal V, Kessler JS, Rein T, Holsboer F, Rupprecht R. Impact of lipid raft integrity on 5-HT3 receptor function and its modulation by antidepressants. Neuropsychopharmacology. 2010 Jun;35(7):1510-9. doi: 10.1038/npp.2010.20. Epub 2010 Mar 3. PMID: 20200506
Zwanzger P, Eser D, Nothdurfter C, Baghai TC, Möller HJ, Padberg F, Rupprecht R. Effects of the GABA-reuptake inhibitor tiagabine on panic and anxiety in patients with panic disorder. Pharmacopsychiatry. 2009 Nov;42(6):266-9. doi: 10.1055/s-0029-1241798. Epub 2009 Nov 18. PMID: 19924586
Rammes G, Hosp C, Eisensamer B, Tanasic S, Nothdurfter C, Zieglgänsberger W, Rupprecht R. Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors. PLoS One. 2009 Aug 21;4(8):e6715. doi: 10.1371/journal.pone.0006715. PMID: 19696922
Rupprecht R, Rammes G, Eser D, Baghai TC, Schüle C, Nothdurfter C, Troxler T, Gentsch C, Kalkman HO, Chaperon F, Uzunov V, McAllister KH, Bertaina-Anglade V, La Rochelle CD, Tuerck D, Floesser A, Kiese B, Schumacher M, Landgraf R, Holsboer F, Kucher K. Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. Science. 2009 Jul 24;325(5939):490-3. doi: 10.1126/science.1175055. Epub 2009 Jun 18. Erratum in: Science. 2009 Aug 28;325(5944):1072. Dosage error in article text. PMID: 19541954
Eser D, Nothdurfter C, Schüle C, Damm J, Steng Y, Möller HJ, Rupprecht R, Baghai T. The influence of anaesthetic medication on safety, tolerability and clinical effectiveness of electroconvulsive therapy. World J Biol Psychiatry. 2010 Mar;11(2 Pt 2):447-56. doi: 10.1080/15622970902960897. PMID: 19462341
Eser D, Baghai TC, Schüle C, Nothdurfter C, Rupprecht R. Neuroactive steroids as endogenous modulators of anxiety. Curr Pharm Des. 2008;14(33):3525-33. Review. PMID: 19075729
Schüle C, Baghai TC, Eser D, Nothdurfter C, Rupprecht R. Lithium but not carbamazepine augments antidepressant efficacy of mirtazapine in unipolar depression: an open-label study. World J Biol Psychiatry. 2009;10(4 Pt 2):390-9. doi: 10.1080/15622970701849978. PMID: 18609420
Eser D, Leicht G, Baghai T, Pogarell O, Schüle C, Karch S, Nothdurfter C, Rupprecht R, Mulert C. Impact of loudness dependency of auditory evoked potentials on the panic response to CCK-4. J Psychiatr Res. 2009 Jan;43(4):393-400. doi: 10.1016/j.jpsychires.2008.04.010. Epub 2008 Jun 4. PMID: 18534623
Nothdurfter C. [The diagnosis is cancer--and then depression?]. MMW Fortschr Med. 2007 Apr 19;149(16):27-30. Review. German. PMID: 17953260
Nothdurfter C, Rammes G, Rein T, Rupprecht R. Pitfalls in isolating lipid rafts. Nat Rev Neurosci. 2007;8:567.
Schüle C, Baghai TC, Eser D, Hecht S, Hermisson I, Born C, Häfner S, Nothdurfter C, Rupprecht R. Mirtazapine monotherapy versus combination therapy with mirtazapine and aripiprazole in depressed patients without psychotic features: a 4-week open-label parallel-group study. World J Biol Psychiatry. 2007;8(2):112-22. PMID:17455104
Baghai TC, Binder EB, Schule C, Salyakina D, Eser D, Lucae S, Zwanzger P, Haberger C, Zill P, Ising M, Deiml T, Uhr M, Illig T, Wichmann HE, Modell S, Nothdurfter C, Holsboer F, Müller-Myhsok B, Möller HJ, Rupprecht R, Bondy B. Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism. Mol Psychiatry. 2006 Nov;11(11):1003-15. Epub 2006 Aug 22. PMID: 16924268
Nothdurfter C, Eser D, Schüle C, Zwanzger P, Marcuse A, Noack I, Möller HJ, Rupprecht R, Baghai TC. The influence of concomitant neuroleptic medication on safety, tolerability and clinical effectiveness of electroconvulsive therapy. World J Biol Psychiatry. 2006;7(3):162-70. PMID: 16861142
Baghai TC, Marcuse A, Brosch M, Schüle C, Eser D, Nothdurfter C, Steng Y, Noack I, Pietschmann K, Möller HJ, Rupprecht R. The influence of concomitant antidepressant medication on safety, tolerability and clinical effectiveness of electroconvulsive therapy. World J Biol Psychiatry. 2006;7(2):82-90. PMID: 16684680
Stübner S, Nothdurfter C, Grohmann R, Eckermann G. SIADH unter Citalopram in Kombination mit Omeprazol, Metoprolol und Ramipril. Psychopharmakotherapie. 2005;12/5, 195-197.