Publikationen der AG Molekulare Neurowissenschaften

Pub_links

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• PubMed

Preprints

• Issa R, Wein S, Milenkovic V, Rupprecht R, Wetzel C, Schwarzbach J (2024) From Cell to Circuit: Investigating FunctionalTopological Changes in iPSC-derived NeuronalNetworks in Major Depressive Disorder. PREPRINT available at Research Square 10.21203/rs.3.rs-4569534/v1.

• Bader S, Jahner T, Dörfelt A, Melchner D, Cardon I, Siegmund H, Brochhausen C, Rupprecht R, Milenkovic V, Wetzel C A comprehensive functional investigation of the human translocator protein 18 kDa (TSPO) in a novel human neuronal cell knockout model: from molecule to depression. PREPRINT available at Research Square 10.21203/rs.3.rs-4024118/v1.
  [https://doi.org/10.21203/rs.3.rs-4024118/v1]

Fokus

• Glanzlicht biomedizinischer Forschung
  https://www.ukr.de/newsroom/detail/glanzlicht-biomedizinischer-forschung-juli-2022
• UR-Studie untersucht die Rolle der Mitochondrien bei Depressionen; Pressemitteilung der Universität Regensburg Link
  
• Glanzlicht biomedizinischer Forschung
  https://www.uni-regensburg.de/medizin/fakultaet/forschung/glanzlichter-biomedizinischer-forschung/2024/index.html#content_toggle_32939

Ausgewählte Publikationen

• Cardon I, Grobecker S, Jenne F, Jahner T, Rupprecht R, Milenkovic VM, Wetzel CH (2024) Serotonin effects on human iPSC-derived neural cell functions: from mitochondria to depression. Molecular Psychiatry. DOI: 10.1038/s41380-024-02538-0 (Manuskript)

• Cardon I, Grobecker S, Kücükoktay S, Bader S, Jahner T, Nothdurfter C, Koschitzki K, Berneburg M, Weber BHF, Stöhr H, Höring M, Liebisch G, Braun F, Rothammer-Hampl T, Riemenschneider MJ, Rupprecht R, Milenkovic VM, Wetzel CH (2024) Mitochondrial and Cellular Function in Fibroblasts, Induced Neurons, and Astrocytes Derived from Case Study Patients: Insights into Major Depression as a Mitochondria-Associated Disease. International Journal of Molecular Sciences 25:963. DOI: 10.3390/ijms25020963 (Link)

• Bader S, Würfel T, Jahner T, Nothdurfter C, Rupprecht R, Milenkovic VM, Wetzel CH. Impact of Translocator Protein 18 kDa (TSPO) Deficiency on Mitochondrial Function and the Inflammatory State of Human C20 Microglia Cells. Cells. 2023; 12(6):954. doi.org/10.3390/cells12060954

• Triebelhorn J, Cardon I, Kuffner K, Bader S, Jahner T, Meindl K, Rothhammer-Hampl T, Riemenschneider MJ, Drexler K, Berneburg M, Nothdurfter C, Manook A, Brochhausen C, Baghai TC, Hilbert S, Rupprecht R, Milenkovic VM, Wetzel CH (2022) Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties. Molecular Psychiatry 10.1038/s41380-022-01660-1.
  Manuskript

• Rupprecht, R., Wetzel, C.H., Dorostkar, M. et al. Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders?. Molecular Psychiatry (2022). doi.org/10.1038/s41380-022-01561-3

• Kuffner, K.; Triebelhorn, J.; Meindl, K.; Benner, C.; Manook, A.; Sudria-Lopez, D.; Siebert, R.; Nothdurfter, C.; Baghai, T.C.; Drexler, K.; Berneburg, M.; Rupprecht, R.; Milenkovic, V.M.; Wetzel, C.H. Major Depressive Disorder is Associated with Impaired Mitochondrial Function in Skin Fibroblasts. Cells 2020, 9, 884. https://www.mdpi.com/2073-4409/9/4/884#abstract

• Milenkovic, V.M.; Slim, D.; Bader, S.; Koch, V.; Heinl, E.; Alvarez-Carbonell, D.; Nothdurfter, C.; Rupprecht, R.; Wetzel, C.H. CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells. Int. J. Mol. Sci. 2019, 20, 3359. https://www.mdpi.com/1422-0067/20/13/3359

• Bader S, Wolf L, Milenkovic VM, Gruber M, Nothdurfter C, Rupprecht R, Wetzel CH (2019) Differential effects of TSPO ligands on mitochondrial function in mouse microglia cells. Psychoneuroendocrinology https://doi.org/10.1016/j.psyneuen.2019.03.029

• Milenkovic, V.M.; Stanton, E.H.; Nothdurfter, C.; Rupprecht, R.; Wetzel, C.H. The Role of Chemokines in the Pathophysiology of Major Depressive Disorder. Int. J. Mol. Sci. 2019, 20, 2283. https://www.mdpi.com/1422-0067/20/9/2283

• Kuffner K, Wetzel C
  Mitochondrien, Bd. 27 Nr. 38 (2018) Blick in die Wissenschaft https://doi.org/10.5283/bidw.v27i38.85

• Milenkovic VM, Bader S, Sudria-Lopez D, Siebert R, Brandl C, et al. (2018) Effects of genetic variants in the TSPO gene on protein structure and stability. PLOS ONE 13(4): e0195627

• Mycielska ME, Dettmer-Wilde K, Rümmele P, Schmidt KM, Prehn C, Milenkovic VM, Jagla W, Madej MG, Lantow M, Schladt MT, Cecil A, Koehl GE, Eggenhofer E, Wachsmuth C, Ganapathy V, Schlitt HJ, Kunzelmann K, Ziegler C, Wetzel CH, Gaumann A, Lang SA, Adamski J, Oefner PJ and Geissler EK
  Extracellular citrate affects critical elements of cancer cell metabolism and supports cancer development in vivo
  Cancer Res March 6 2018 DOI: 10.1158/0008-5472.CAN-17-2959

• Milenkovic VM, Sarubin N, Hilbert S, Baghai TC, Stöffler F, et al. Macrophage-Derived Chemokine: A Putative Marker of Pharmacological Therapy Response in Major Depression?. Neuroimmunomodulation. 2017;24(2):106-112. PubMed PMID: 28898872.

• Jendryke T, Prochazkova M, Hall BE, Nordmann GC, Schladt M, Milenkovic VM, Kulkarni AB, Wetzel CH. TRPV1 function is modulated by Cdk5-mediated phosphorylation: insights into the molecular mechanism of nociception. Scientific Reports, 2016/02/23/online, http://dx.doi.org/10.1038/srep22007, http://www.nature.com/articles/srep22007#supplementary-information

• Milenkovic A, Brandl C, Milenkovic VM, Jendryke T, Sirianant L, Wanitchakool P, Zimmermann S, Reiff CM, Horling F, Schrewe H, Schreiber R, Kunzelmann K, Wetzel CH, Weber BH. Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells. Proc Natl Acad Sci U S A. 2015 May 4;PubMed PMID: 25941382.

• Milenkovic VM, Rupprecht R, Wetzel CH. The translocator protein 18 kDa (TSPO) and its role in mitochondrial biology and psychiatric disorders. Mini Rev Med Chem. 2015 Mar 24;PubMed PMID: 25807946.

• Wolf L, Bauer A, Melchner D, Hallof-Buestrich H, Stoertebecker P, et al. Enhancing Neurosteroid Synthesis - Relationship to the Pharmacology of Translocator Protein (18 kDa) (TSPO) Ligands and Benzodiazepines. Pharmacopsychiatry. 2015 Feb 5;PubMed PMID: 25654303. 

• Tang Z, Kim A, Masuch T, Park K, Weng H, Wetzel C, Dong X. Pirt functions as an endogenous regulator of TRPM8. Nat Commun. 2013 Jul 17;4:2179. PubMed PMID: 23863968.

• Klasen K, Hollatz D, Zielke S, Gisselmann G, Hatt H, Wetzel CH. The TRPM8 ion channel comprises direct Gq protein-activating capacity. Pflugers Arch. 2012 Jun;463(6):779-97. PubMed PMID: 22460725.

• Doerner JF, Gisselmann G, Hatt H, Wetzel CH. Transient receptor potential channel A1 is directly gated by calcium ions. J Biol Chem. 2007 May 4;282(18):13180-9. PubMed PMID: 17353192.

• Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, Zimmer RK, Hatt H. Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science. 2003 Mar 28;299(5615):2054-8. PubMed PMID: 12663925.

• Spehr M, Hatt H, Wetzel CH. Arachidonic acid plays a role in rat vomeronasal signal transduction. J Neurosci. 2002 Oct 1;22(19):8429-37. PubMed PMID: 12351717.

• Spehr M, Wetzel CH, Hatt H, Ache BW. 3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons. Neuron. 2002 Feb 28;33(5):731-9. PubMed PMID: 11879650.

• Wetzel CH, Behrendt HJ, Gisselmann G, Störtkuhl KF, Hovemann B, Hatt H. Functional expression and characterization of a Drosophila odorant receptor in a heterologous cell system. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9377-80. PubMed PMID: 11481494; PubMed Central PMCID: PMC55428.

• Wetzel CH, Oles M, Wellerdieck C, Kuczkowiak M, Gisselmann G, Hatt H. Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus Laevis oocytes. J Neurosci. 1999 Sep 1;19(17):7426-33. PubMed PMID: 10460249.