Publikationen (seit September 2017):
Stauner CT, Drexler K, Berneburg M, Haferkamp S.J (2018) Komplette Remission eines Patienten mit metastasierten Uveamelanom nach initialem Progress unter Immuntherapie mit Pembrolizumab. Dtsch Dermatol Ges. 2018:1376-1378 https://pubmed.ncbi.nlm.nih.gov/30395409
Stauner CT, Drexler K, Berneburg M, Haferkamp S. (2018). Complete response to pembrolizumab after initial progress in a patient with metastatic uveal melanoma. J Dtsch Dermatol Ges. 2018 Nov;16(11):1376-1378.
https://pubmed.ncbi.nlm.nih.gov/30299577/
Kamenisch Y, Ivanova I, Drexler K, Berneburg M. (2018) UVA, metabolism and melanoma: UVA makes melanoma hungry for metastasis. Exp Dermatol. 2018 Sep;27(9):941-949.
https://pubmed.ncbi.nlm.nih.gov/29658146/
Ji X, Qian J, Rahman SMJ, Siska PJ, Zou Y, Harris BK, Hoeksema MD, Trenary IA, Heidi C, Eisenberg R, Rathmell JC, Young JD, Massion PP. "xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression." Oncogene. 2018 Sep;37(36): 5007-5019.
https://pubmed.ncbi.nlm.nih.gov/29789716/
Schnell A, Schmidl C, Herr W, Siska PJ. "The Peripheral and Intratumoral Immune Cell Landscape in Cancer Patients: A Proxy for Tumor Biology and a Tool for Outcome Prediction." Biomedicines. 2018 Feb 24;6(1): 25
https://pubmed.ncbi.nlm.nih.gov/29495308/
Zhao F, Evans K, Xiao C, DeVito N, Theivanthiran B, Holtzhausen A, Siska PJ, Blobe GC, Hanks BA. "Stromal Fibroblasts Mediate Anti-PD-1 Resistance via MMP-9 and Dictate TGFβ Inhibitor Sequencing in Melanoma." Cancer Immunol Res. 2018, 6(12):1459-1471.
https://pubmed.ncbi.nlm.nih.gov/30209062/
Gemta LF, Siska PJ, Nelson ME, Gao X, Liu X, Locasale JW, Yagita H, Slingluff CL Jr, Hoehn KL, Rathmell JC, Bullock TNJ. "Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells." Sci Immunol. 2019 Jan 25, 4(31):eaap9520
https://pubmed.ncbi.nlm.nih.gov/30683669/
Schnell A, Schmidl C, Herr W, Siska PJ. The Peripheral and Intratumoral Immune Cell Landscape in Cancer Patients: A Proxy for Tumor Biology and a Tool for Outcome Prediction. Biomedicines. 2018;6(1):25.
https://pubmed.ncbi.nlm.nih.gov/29495308/
Heimer S, Knoll G, Steixner C, Calance DN, Trinh DT, Ehrenschwender M. Hypertonicity-imposed BCL-XL addiction primes colorectal cancer cells for death. Cancer Lett. 2018;435:23-31.
https://pubmed.ncbi.nlm.nih.gov/30075205/
Singer K, Cheng WC, Kreutz M, Ho PC, Siska PJ. Immunometabolism in cancer at a glance. Dis Model Mech. 2018;11(8):dmm034272.
https://pubmed.ncbi.nlm.nih.gov/30076128/
van Bruggen JAC, Martens AWJ, Fraietta JA, Hofland T, Tonino SH, Eldering E, Levin MD, Siska PJ, Endstra S, Rathmell JC, June CH, Porter DL, Melenhorst JJ, Kater AP, van der Windt GJW. Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T cell efficacy. Blood 2019;134(1):44-58.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022375/
Heimer S, Knoll G, Schulze-Osthoff K, Ehrenschwender M. Raptinal bypasses BAX, BAK, and BOK for mitochondrial outer membrane permeabilization and intrinsic apoptosis. Cell Death Dis. 2019 Jul 19;10(8):556.
10.1038/s41419-019-1790-z
Li C, Zhu B, Son YM, Wang Z, Jiang L, Xiang M, Ye Z, Beckermann KE, Wu Y, Jenkins JW, Siska PJ, Vincent BG, Prakash YS, Peikert T, Edelson BT, Taneja R, Kaplan MH, Rathmell JC, Dong H, Hitosugi T, Sun J. The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality. Immunity. 2019;51(3):491-507.e7. doi: 10.1016/j.immuni.2019.08.013. (Erratum published in Immunity 2020;52(1):201-202. doi: 10.1016/j.immuni.2019.12.008).
https://pubmed.ncbi.nlm.nih.gov/31533057/
Kuffner K, Triebelhorn J, Meindl K, Benner C, Manook A, Sudria-Lopez D, Siebert R, Nothdurfter C, Baghai TC, Drexler K, Berneburg M, Rupprecht R, Milenkovic VM, Wetzel CH. Major depressive disorder is associated with impaired mitochondrial function in skin fibroblasts. Cells. 2020;9(4):884.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226727/
Siska PJ, Singer K, Evert K, Renner K, Kreutz M. The immunological Warburg effect: Can a metabolic-tumor-stroma score (MeTS) guide cancer immunotherapy? Immunol Rev 2020; 295(1):187-202.
https://pubmed.ncbi.nlm.nih.gov/32157706/
Steeb T, Wessely A, von Bubnoff D, Dirschka T, Drexler K. Treatment Motivations and Expectations in Patients with Actinic Keratosis: A German-Wide Multicenter, Cross-Sectional Trial. J Clin Med. 2020;9(5):1438.
https://pubmed.ncbi.nlm.nih.gov/32408601/
Steeb T, Wessely A, Drexler K, Salzmann M, Toussaint F, Heinzerling L, Reinholz M, Berking C, Heppt MV. The Quality of Practice Guidelines for Melanoma: A Methodologic Appraisal with the AGREE II and AGREE-REX Instruments. Cancers (Basel). 2020;12(6):1613.
https://www.mdpi.com/2072-6694/12/6/1613
Anssar TM, Hau P. Darmmikrobiom bei primären Hirntumoren. Datenlage und Hypothesen. Nervenheilkunde. 2020;39(01/02):31-39.
https://doi.org/10.1055/a-1037-2271
Anssar TM, Leitzmann MF, Linker RA, Meier C, Becker C, Jick S, Sahm K, Platten M, Hau P, Seliger C. Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma. Cancer Med. 2020; 9(3):1263-1275.
https://doi.org/10.1002/cam4.2767
Haferkamp S, Drexler K, Federlin M, Schlitt HJ, Berneburg M, Adamski J, Gaumann A, Geissler EK, Ganapathy V, Parkinson EK, Mycielska ME. Extracellular citrate fuels cancer cell metabolism and growth. Front Cell Dev Biol. 2020;8:602476.
https://www.frontiersin.org/articles/10.3389/fcell.2020.602476/full
Trum M, Riechel J, Wagner S. Cardioprotection by SGLT2 Inhibitors-Does It All Come Down to Na+? Int J Mol Sci. 2021;22(15):7976.
https://pubmed.ncbi.nlm.nih.gov/34360742/
Heimer S, Knoll G, Neubert P, Hammer KP, Wagner S, Bauer RJ, Jantsch J, Ehrenschwender M. Hypertonicity counteracts MCL-1 and renders BCL-XL a synthetic lethal target in head and neck cancer. FEBS J. 2021;288(6):1822-1838.
https://doi.org/10.1111/febs.15492
Meedt E, Hiergeist A, Gessner A, Dettmer K, Liebisch G, Ghimire S, Poeck H, Edinger M, Wolff D, Herr W, Holler E, Weber D. Prolonged suppression of butyrate producing bacteria is associated with acute gastrointestinal graft-versus-host disease and transplant related mortality after allogeneic stem cell transplantation. Clin Infect Dis. 2021;ciab500.
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab500/6287098
Drexler K, Schmidt KM, Jordan K, Federlin M, Milenkovic VM, Liebisch G, Artati A, Schmidl C, Madej G, Tokarz J, Cecil A, Jagla W, Haerteis S, Aung T, Wagner C, Kolodziejczyk M, Heinke S, Stanton EH, Schwertner B, Riegel D, Wetzel CH, Buchalla W, Proescholdt M, Klein CA, Berneburg M, Schlitt HJ, Brabletz T, Ziegler C, Parkinson EK, Gaumann A, Geissler EK, Adamski J, Haferkamp S, Mycielska ME. Cancer-associated cells release citrate to support tumour metastatic progression. Life Sci Alliance. 2021;4(6):e202000903.
https://pubmed.ncbi.nlm.nih.gov/33758075/
Ghimire S, Weber D, Hippe K, Meedt E, Hoepting M, Kattner AS, Hiergeist A, Gessner A, Matos C, Ghimire S, Wolff D, Edinger M, Hoffmann P, Poeck H, Herr W, Holler E. GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics. Front Immunol. 2021;12:753287.
https://www.frontiersin.org/articles/10.3389/fimmu.2021.753287/full
Drexler K, Drexler H, Geissler EK, Berneburg M, Haferkamp S, Apfelbacher C. Incidence and Mortality of Malignant Melanoma in Relation to Dermatologist Density in Bavaria. Adv Ther. 2021;38(11):5548-5556.
https://pubmed.ncbi.nlm.nih.gov/34596866/
Siska PJ, Decking SM, Babl N, Matos C, Bruss C, Singer K, Klitzke J, Schön M, Simeth J, Köstler J, Siegmund H, Ugele I, Paulus M, Dietl A, Kolodova K, Steines L, Freitag K, Peuker A, Schönhammer G, Raithel J, Graf B, Geismann F, Lubnow M, Mack M, Hau P, Bohr C, Burkhardt R, Gessner A, Salzberger B, Wagner R, Hanses F, Hitzenbichler F, Heudobler D, Lüke F, Pukrop T, Herr W, Wolff D, Spang R, Poeck H, Hoffmann P, Jantsch J, Brochhausen C, Lunz D, Rehli M, Kreutz M, Renner K. Metabolic imbalance of T cells in COVID-19 is hallmarked by basigin and mitigated by dexamethasone. J Clin Invest. 2021;131(22):e148225.
https://pubmed.ncbi.nlm.nih.gov/34779418/
Bengel P, Dybkova N, Tirilomis P, Ahmad S, Hartmann N, A Mohamed B, Krekeler MC, Maurer W, Pabel S, Trum M, Mustroph J, Gummert J, Milting H, Wagner S, Ljubojevic-Holzer S, Toischer K, Maier LS, Hasenfuss G, Streckfuss-Bömeke K, Sossalla S. Detrimental proarrhythmogenic interaction of Ca2+/calmodulin-dependent protein kinase II and NaV1.8 in heart failure. Nat Commun. 2021;12(1):6586.
https://pubmed.ncbi.nlm.nih.gov/34782600/
Siska PJ, Jiao J, Matos C, Singer K, Berger RS, Dettmer K, Oefner PJ, Cully MD, Wang Z, QuinnIII WJ, Oliff KN, Wilkins BJ, Christensen LM, Wang L, Hancock WW, Baur JA, Levine MH, Ugele I, Mayr R, Renner K, Zhou L, Kreutz M, Beier UH. Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo. EBioMedicine. 2021;74:103734.
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00528-4/fulltext
Tauber P, Sinha F, Berger RS, Gronwald W, Dettmer K, Kuhn M, Trum M, Maier LS, Wagner S, Schweda F. Empagliflozin Reduces Renal Hyperfiltration in Response to Uninephrectomy, but Is Not Nephroprotective in UNx/DOCA/Salt Mouse Models. Front Pharmacol. 2021;12: 761855.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724563/
Spoerl S, Spanier G, Reiter E, Gerken M, Haferkamp S, Grosse J, Drexler K, Ettl T, Klinkhammer-Schalke M, Fischer R, Spoerl S, Reichert TE, Klingelhöffer C. Head and neck melanoma: outcome and predictors in a population-based cohort study. Head Face Med. 2021;17(1):45.
https://head-face-med.biomedcentral.com/articles/10.1186/s13005-021-00295-x
Schröder A, Schöniger R, Oeldemann J, Spanier G, Proff P, Jantsch J, Kirschneck C, Ullrich N. An Evaluation of Different 3D Cultivation Models on Expression Profiles of Human Periodontal Ligament Fibroblasts with Compressive Strain. Int J Mol Sci. 2022;23(4):2029.
https://doi.org/10.3390/ijms23042029
Veranstaltungen
Professor Sergio Rutella, Nottingham Trent University, UK
Vortragstitel: "Interferon signalling and immune dysfunction in acute myeloid leukaemia"
25. April 2018
Präsentationen im Rahmen der Fakultätsklausur bzw. der Habilitationsvorträge
Mai und Juni 2018
Univ.-Prof. Dr. med. Tim Sparwasser
TWINCORE - Zentrum f. Experimentelle und Klinische Infektionsforschung GmbH
27. Februar 2019
Prof. Dr. Nicole Joller, Universität Zürich
Thema: "Specialization of Regulatory T cells in Th1 Responses“
21. März 2019
Präsentationen im Rahmen der Fakultätsklausur bzw. der Habilitationsvorträge
Mai und Juni 2019
Dr. Markus Diefenbacher
Lehrstuhl für Biochemie und Molekularbiologie, Universität Würzberg
26. Juni 2019
Informations- und Kennenlernveranstaltung für neue Kollegiat/innen
Dezember 2020
Intramurales Symposium von und für alle Kollegiat/innen
07. Oktober 2021
Sowie viele weitere Veranstaltungen von und für Nachwuchswissenschaftler/innen.
Exemplarisch seien hier die Symposium der Forschungsgruppen FOR2127 erwähnt.
