sensor technologies

 Signal am

plification strategies are central to our sensor development and embrace a variety of different approaches including investigations toward highly sensitive detection strategies using electrochemical methods, electrochemiluminescence, and luminescence, as well as new materials such as upconverting nanoparticles, 2D nanomaterials and nanofibers . These find their application in the highly sensitive, multi-analyte detection of pathogens, toxins, cells and metabolites ranging from protozoan parasites like Cryptosporidium parvum to the blood clotting protein thrombin.

For example:

• Bauer, M., Duerkop, A., Baeumner, A.J. “Critical review of polymer and hydrogel deposition methods for optical and electrochemical bioanalytical sensors correlated to the sensor’s applicability in real samples.” Analytical and Bioanalytical Chemistry, (2022) 415, 83 – 95, https://doi.org/10.1007/s00216-022-04363-2
• Perju, A.T., Baeumner, A.J., Wongkaew, N., “Freestanding 3D-interconnected carbon nanofibers as high-performance transducers in miniaturized electrochemical sensors” Microchimica Acta (2022), 189, 424, https://doi.org/10.1007/s00604-022-05492-2

• Gerstl, F., Pongkitdachoti. U., Unob, F. and Baeumner, A.J. “Miniaturized Sensor for Electroanalytical and Electrochemiluminescent Detection of Pathogens enabled through Laser-Induced Graphene Electrodes embedded in Microfluidic Channels” Lab on a Chip (2022) 22, 3721 – 3733, https://doi.org/10.1039/D2LC00593J

• Beck, F., Horn, C., Baeumner, A.J. “Ag Nanoparticles Outperform Au Nanoparticles for the Use as Label in Electrochemical Point-of-Care Sensors” Analytical and Bioanalytical Chemistry (2021) 475 – 483, https://doi.org/10.1007/s00216-021-03288-6

• Kirschbaum-Harriman, S. E. K., Mayer, M., Duerkop, A., Hirsch, T., Baeumner, A.J. „Signal enhancement and low oxidation potential for miniaturized ECL biosensors via N-butyldiethanolamine“ (2017) Analyst, 2017, 142, 2469 – 2474, DOI: 10.1039/C7AN00261K

• Genslein, C., Hausler, P, Kirchner, E-M., Bierl, R., Baeumner, A.J., Hirsch, T. „Graphene-enhanced plasmonic nanohole arrays for environmental sensing in aqueous samples“ Beilstein J. Nanotechnol., vol. 7, pp. 1564 – 1573 (2016), DOI: 10.3762/bjnano.7.150

• Matlock-Colangelo, L.E., Coon, B., Pitner, C.L., Frey, M.W., Baeumner, A.J. “Functionalized electrospun poly(vinyl alcohol) nanofibers for on-chip concentration of E. coli cells” Analytical and Bioanalytical Chemistry, 408(5), 1327-1334 (2016), DOI: 10.1007/s00216-015-9112-5

• Fenzl, C., Genslein, C., Zoepfl, A., Baeumner, A.J., Hirsch, T. “Photonic crystal based sensing scheme for acetylchloline and acetylcholinesterase inhibitors” J. Materials Chemistry B vol. 3, pp. 2089 – 2095 (2015), DOI: 10.1039/c4tb01970a

• Reinholt, S., Behrent, A., Greene, C., Kalfe, A., Baeumner, A.J. “Isolation and Amplification of mRNA within a Simple Microfluidic Lab on a Chip” Anal. Chem vol. 86(1), pp. 849 - 856 (2014), DOI: 10.1021/ac403417z,  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923508/

• Edwards, K.A., Meyers, K.J., Leonard, B., Connelly, J.T., Wang, Y., Holter, T., Baeumner, A.J. “Engineering Liposomes as Detection Reagents for CD4+ T-cells” Analytical Methods, vol. 4 (12), pp. 3948 – 3955 (2012), DOI: 10.1039/C2AY25480H

• Connelly, J.T; Kondapalli, S., Skoupi, M., Parker, S.L., Kirby, B.J, Baeumner. A.J. “Micro-total analysis system for virus detection: microfluidic pre-concentration coupled to liposome-based detection” Analytical and Bioanalytical Chemistry, 402(1) pp. 315-323 (2012) DOI: 10.1007/s00216-011-5381-9

• Nugen, S.R., Asiello, P.J., Connelly, J.T., Baeumner, A.J. “PMMA biosensor for nucleic acids with integrated mixer and electrochemical detection” Biosensors and Bioelectronics, vol. 24, pp. 2428 – 2433 (2009), DOI: 10.1016/j.bios.2008.12.025

• Bunyakul, N., Edwards, K.A., Promptmas, C., Baeumner, A.J. “Cholera toxin subunit B detection in microfluidic devices” Analytical and Bioanalytical Chemistry, vol. 393(1), p. 177 – 186, Special anniversary issue. (2009), DOI: 10.1007/s00216-008-2364-6

• Natalya V. Zaytseva, Vasiliy N. Goral, Richard A. Montagna, and Antje J. Baeumner “Development of a microfluidic biosensor module for pathogen detection” Lab-on-chip, vol 5 (8), pp. 805 – 811 (2005), DOI: 10.1039/B503856A (issue cover picture)

• Baeumner, A.J., Pretz, J., Fang, S. “A Universal Nucleic Acid Sequence Biosensor with Nanomolar Detection Limits”, Analytical Chemistry, vol. 76 (4), pp. 888 – 894 (2004), DOI: 10.1021/ac034945l