Prof. Dr. Jörg Heilmann

Prof. Heilmann

Lehrstuhlinhaber

Heilmann

Gebäude Chemie-Pharmazie, Zi. CH 14.2.81
Telefon: +49 (0)941 943-4759
Fax: +49 (0)941 943-4990
E-Mail: joerg.heilmann@chemie.uni-regensburg.de

Sekretariat

Verwaltungsangestellte

Hedwig Ohli

Ohli 201908

Gebäude Chemie-Pharmazie, Zi. CH 14.2.82
Telefon: +49 (0)941 943-4761
Fax: +49 (0)941 943-4990
E-Mail: hedwig.ohli@chemie.uni-regensburg.de

Vita

Geburtstag: 28.05.1966

Geburtsort: Mülheim an der Ruhr, Bundesrepublik Deutschland

Eltern: Wilhelm Heilmann, Helma Heilmann, geb. Löhr

Gegenwärtiger Wohnsitz: Regensburg (D)

Berufsausbildung

WS 1985/86 - SS 1990: Studium der Pharmazie an der Heinrich-Heine-Universität Düsseldorf

1990/1991: Pharmaziepraktikum, Löwen Apotheke, Mülheim an der Ruhr

1991: Approbation als Apotheker

Berufliche Tätigkeiten

1991/1992: Angestellter Apotheker, Löwen Apotheke, Mülheim an der Ruhr

1992-1997: Wissenschaftliche Hilfskraft und wissenschaftlicher Angestellter am Institut für Pharmazeutische Biologie der Heinrich-Heine-Universität, Düsseldorf

1997: Angestellter Apotheker, Alte Apotheke Bottrop

1997-1998: Post-Doc am Institut für Pharmazeutische Biologie der Heinrich-Heine-Universität Düsseldorf

1998-2002: Oberassistent und Dozent am Departement Angewandte Biowissenschaften der ETH Zürich, Abteilung Pharmakognosie/Phytochemie

Akademische Laufbahn

1994-1997: Ausbildung zum Fachapotheker für Pharmazeutische Analytik

1997: Promotion ("Phytochemische Untersuchungen der Blüten von Buphthalmum salicifolium L. sowie Studien zur antiphlogistischen Wirkung und zur Penetration von Flavonoiden und deren Metaboliten" unter Anleitung von Frau Prof. Dr. I. Merfort)

1997: Fachapotheker für Pharmazeutische Analytik

1997/1998: Post-Doc in der Arbeitgruppe von Prof. Dr. R. Bauer (Fragestellungen zur Aktivität von Naturstoffen in einem 5-Lipoxygenase Testsystem)

1998-2002: Oberassistent und Dozent in der Arbeitsgruppe von Prof. Dr. O. Sticher

2002: Abgabe der Habilitationsschrift (Biological and chemical investigations on the cytotoxicity and antioxidative activity of natural products)

07.01.2003: Ernennung zum Privatdozenten und Erteilung der Venia legendi für das Fachgebiet Pharmazeutische Biologie

01.04.2002 - 01.07.2003: Kommissarischer Leiter der Arbeitsgruppe Phytochemie/ Pharmakognosie

September 2003: Egon-Stahl Preis in Silber

Oktober 2003: A. Vogel Preis

01.04.2004: Vertretung der C-4 Professur für Pharmazeutische Biologie der Friedrich-Schiller-Universität Jena

August 2004: Ruf auf die C-4 Professur für Pharmazeutische Biologie der Universität Regensburg

01.12.2004: Annahme des Rufs nach Regensburg und Ernennung zum C-4 Professor

Publikationen

I.a. Original Paper

Unterholzner A, Kuck K, Weinzierl A, Lipowicz B, Heilmann J. An Unprecedented 4,8-Cycloeudesmane, Further New Sesquiterpenoids, a Triterpene, Steroids, and a Lignan from the Resin of Commiphora myrrha and Their Anti-Inflammatory Activity In Vitro Molecules. 2024 Sep 11;29(18):4315. doi: 10.3390/molecules29184315.
Ferrando Plo L, Nitsopoulos A, Friedle A, Schmidberger A, Heilmann J. Anthraquinone Residues in Dried Walnut (Juglans regia) Leaves for Herbal Infusions: Proof of Endogenous Origin via a Sampling-Driven and GC-MS/MS-Based Strategy J Agric Food Chem. 2024 Nov 20. doi: 10.1021/acs.jafc.4c08102. Online ahead of print.
Grafakou ME, Barda C, Skaltsa H, Heilmann J. Study on the metabolism of natural sesquiterpene lactones in human liver microsomes using LC-Q-TOF-MS/MS Nat Prod Res. 2024 Jun;38(11):1855-1863. doi: 10.1080/14786419.2023.2226301. Epub 2023 Jun 24.
Gertsch J, Heilmann J, Skaltsa H. Editorial Phytochemistry. 2023 Sep;213:113781. doi: 10.1016/j.phytochem.2023.113781. Epub 2023 Jun 27.
Kuck K, Unterholzner A, Lipowicz B, Schwindl S, Jürgenliemk G, Schmidt TJ, Heilmann J. Terpenoids from Myrrh and Their Cytotoxic Activity against HeLa Cells Molecules. 2023 Feb 8;28(4):1637. doi: 10.3390/molecules28041637.
Barda C, Tzoumaka A, Grafakou ME, Kalpoutzakis E, Heilmann J, Skaltsa H. Phytochemical Characterization of Phitosia crocifolia, a Monotypic Representative of Greek Flora Planta Med. 2023 Mar;89(3):324-332. doi: 10.1055/a-1939-7473. Epub 2023 Jan 10.
Bunse M, Daniels R, Gründemann C, Heilmann J, Kammerer DR, Keusgen M, Lindequist U, Melzig MF, Morlock GE, Schulz H, Schweiggert R, Simon M, Stintzing FC, Wink M. Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being Front Pharmacol. 2022 Aug 24;13:956541. doi: 10.3389/fphar.2022.956541. eCollection 2022.
Greinwald A, Hartmann M, Heilmann J, Heinrich M, Luick R, Reif A. Soil and Vegetation Drive Sesquiterpene Lactone Content and Profile in Arnica montana L. Flower Heads From Apuseni-Mountains, Romania Front Plant Sci. 2022 Jan 28;13:813939. doi: 10.3389/fpls.2022.813939. eCollection 2022.
Grafakou ME, Barda C, Heilmann J, Skaltsa H. In vitro cytotoxic and anti-inflammatory activities of sesquiterpene lactones from Centaurea papposa (Coss.) Greuter Nat Prod Res. 2022 Jun;36(12):3211-3215. doi: 10.1080/14786419.2021.1955882. Epub 2021 Aug 6.
Barda C, Anastasiou K, Tzara A, Grafakou ME, Kalpoutzakis E, Heilmann J, Rallis M, Kourounakis AP, Skaltsa H. A Bio-Guided Screening for Antioxidant, Anti-Inflammatory and Hypolipidemic Potential Supported by Non-Targeted Metabolomic Analysis of Crepis spp. Molecules. 2022 Sep 20;27(19):6173. doi: 10.3390/molecules27196173.
Grafakou ME, Barda C, Pintać D, Lesjak M, Heilmann J, Skaltsa H. Prenylated Acylphloroglucinols from Hypericum jovis with Anti-inflammatory Potential Planta Med. 2021 Nov;87(14):1184-1191. doi: 10.1055/a-1556-9721.
Daskalaki A, Grafakou ME, Barda C, Kypriotakis Z, Heilmann J, Skaltsa H. Secondary metabolites from Hypericum trichocaulon Boiss. & Heldr., growing wild in the island of Crete, Biochemical Systematics and Ecology, 97, 104294, 2021. doi: 10.1016/j.bse.2021.104294
Max J, Heilmann J. Homoadamantane and Adamantane Acylphloroglucinols from Hypericum hirsutum Planta Med. 87(14):1167-1183, 2021. doi: 10.1055/a-1617-7573. Epub 2021 Oct 1.
Tremmel M, Paetz C, Heilmann J. In Vitro Liver Metabolism of Six Flavonoid C-Glycosides Molecules. 2021 Nov 1;26(21):6632. doi: 10.3390/molecules26216632.
Tremmel M, Kiermaier J, Heilmann J. In Vitro Metabolism of Six C-Glycosidic Flavonoids from Passiflora incarnata L Int J Mol Sci. 2021 Jun 18;22(12):6566. doi: 10.3390/ijms22126566.
Mandigma MJP, Žurauskas J, MacGregor CI, Edwards LJ, Shahin A, d'Heureuse L, Yip P, Birch DJS, Gruber T, Heilmann J, John MP, Barham JP. An organophotocatalytic late-stage N-CH(3) oxidation of trialkylamines to N-formamides with O(2) in continuous flow Chem Sci. 2021 Dec 28;13(7):1912-1924. doi: 10.1039/d1sc05840a. eCollection 2022 Feb 16.
Heilmann J. A (Far Too Short) Homage to Prof. Otto Sticher in Honor of His 85th Birthday Planta Med. 2021 Nov;87(14):1120-1121. doi: 10.1055/a-1485-0187. Epub 2021 Nov 11.
Grafakou ME, Barda C, Karikas GA, Heilmann J, Skaltsa H. Cajamolides A-N: Cytotoxic and anti-inflammatory sesquiterpene lactones from Calea jamaicensis Bioorg Chem. 2021 Nov;116:105351. doi: 10.1016/j.bioorg.2021.105351. Epub 2021 Sep 11.
Grafakou ME, Barda C, Heilmann J, Skaltsa H. Macrocyclic Diterpenoid Constituents of Euphorbia deflexa, an Endemic Spurge from Greece J Nat Prod. 2021 Nov 26;84(11):2893-2903. doi: 10.1021/acs.jnatprod.1c00654. Epub 2021 Oct 19.
Kuck K, Jürgenliemk G, Lipowicz B, Heilmann J. Sesquiterpenes from Myrrh and Their ICAM-1 Inhibitory Activity In Vitro Molecules. 2020 Dec 23;26(1):42. doi: 10.3390/molecules26010042.
Pontes de Sousa I, Ferreira AG, Miller Crotti AE, Alves Dos Santos R, Kiermaier J, Kraus B, Heilmann J, Jacometti Cardoso Furtado NA. New antifungal ent-labdane diterpenes against Candida glabrata produced by microbial transformation of ent-polyalthic acid Bioorg Chem. 2020 Jan;95:103560. doi: 10.1016/j.bioorg.2019.103560. Epub 2019 Dec 28.
Weber L, Kuck K, Jürgenliemk G, Heilmann J, Lipowicz B, Vissiennon C. Anti-Inflammatory and Barrier-Stabilising Effects of Myrrh, Coffee Charcoal and Chamomile Flower Extract in a Co-Culture Cell Model of the Intestinal Mucosa Biomolecules. 2020 Jul 11;10(7):1033. doi: 10.3390/biom10071033.
Untergehrer M, Kiermaier J, Reintjes S, Heilmann J, Jürgenliemk G. Identification of phase-II metabolites from human serum samples after oral intake of a willow bark extract Phytomedicine. 2019 Apr;57:396-402. doi: 10.1016/j.phymed.2018.11.003. Epub 2018 Nov 6.
Wiesneth S, Aas G, Heilmann J, Jürgenliemk G. Investigation of the flavan-3-ol patterns in willow species during one growing-season Phytochemistry. 2018 Jan;145:26-39. doi: 10.1016/j.phytochem.2017.10.001. Epub 2017 Oct 20.
Mathioudaki A, Berzesta A, Kypriotakis Z, Skaltsa H, Heilmann J. Phenolic metabolites from Hypericum kelleri Bald., an endemic species of Crete (Greece) Phytochemistry. 2018 Feb;146:1-7. doi: 10.1016/j.phytochem.2017.11.009. Epub 2017 Dec 22.
Makule E, Schmidt TJ, Heilmann J, Kraus B. Diarylheptanoid Glycosides of Morella salicifolia Bark Molecules. 2017 Dec 19;22(12):2266. doi: 10.3390/molecules22122266.
Schwindl S, Kraus B, Heilmann J. Phytochemical study of Juglans regia L. leaves Phytochemistry. 2017 Dec;144:58-70. doi: 10.1016/j.phytochem.2017.08.012. Epub 2017 Sep 8.
Huang G, Drakopoulos A, Saedtler M, Zou H, Meinel L, Heilmann J, Decker M. Cytotoxic properties of the alkaloid rutaecarpine and its oligocyclic derivatives and chemical modifications to enhance water-solubility Bioorg Med Chem Lett. 2017 Nov 1;27(21):4937-4941. doi: 10.1016/j.bmcl.2017.08.045. Epub 2017 Aug 24.
Jones M, Wang J, Harmon S, Kling B, Heilmann J, Gilmer JF. Novel Selective Butyrylcholinesterase Inhibitors Incorporating Antioxidant Functionalities as Potential Bimodal Therapeutics for Alzheimer's Disease Molecules. 2016 Apr 1;21(4):440. doi: 10.3390/molecules21040440.
Lorenz P, Knittel DN, Conrad J, Lotter EM, Heilmann J, Stintzing FC, Kammerer DR. 1-Acetyl-3-[(3R)-hydroxyfatty acyl]glycerols: Lipid Compounds from Euphrasia rostkoviana Hayne and E. tetraquetra (Bréb.) Arrond Chem Biodivers. 2016 May;13(5):602-12. doi: 10.1002/cbdv.201500233.
Huang G, Schramm S, Heilmann J, Biedermann D, Křen V, Decker M. Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins Beilstein J Org Chem. 2016 Apr 8;12:662-9. doi: 10.3762/bjoc.12.66. eCollection 2016.
Sawatzky E, Wehle S, Kling B, Wendrich J, Bringmann G, Sotriffer CA, Heilmann J, Decker M. Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode J Med Chem. 2016 Mar 10;59(5):2067-82. doi: 10.1021/acs.jmedchem.5b01674. Epub 2016 Feb 17.
Sun Q, Heilmann J, König B. Natural phenolic metabolites with anti-angiogenic properties - a review from the chemical point of view Beilstein J Org Chem. 2015 Feb 16;11:249-64. doi: 10.3762/bjoc.11.28. eCollection 2015.
Nedialkov PT, Momekov G, Kokanova-Nedialkova ZK, Heilmann J. Polyprenylated Phloroglucinols from Hypericum maculatum Nat Prod Commun. 2015 Jul;10(7):1231-5.
Flemming M, Kraus B, Rascle A, Jürgenliemk G, Fuchs S, Fürst R, Heilmann J. Revisited anti-inflammatory activity of matricine in vitro: Comparison with chamazulene Fitoterapia. 2015 Oct;106:122-8. doi: 10.1016/j.fitote.2015.08.010. Epub 2015 Aug 21.
Untergehrer M, Bücherl D, Wittmann HJ, Strasser A, Heilmann J, Jürgenliemk G. Structure-Dependent Deconjugation of Flavonoid Glucuronides by Human β-Glucuronidase - In Vitro and In Silico Analyses Planta Med. 2015 Aug;81(12-13):1182-9. doi: 10.1055/s-0035-1545980. Epub 2015 May 27.
Kokanova-Nedialkova Z, Kondeva-Burdina M, Zheleva-Dimitrova D, Tzankova V, Nikolov S, Heilmann J, Nedialkov PT. 6-Methoxyflavonol Glycosides with In Vitro Hepatoprotective Activity from Chenopodium bonus-henricus Roots Nat Prod Commun. 2015 Aug;10(8):1377-80.
Macabeo AP, Martinez FP, Kurtán T, Tóth L, Mándi A, Schmidt S, Heilmann J, Alejandro GJ, Knorn M, Dahse HM, Franzblau SG. Tetrahydroxanthene-1,3(2H)-dione derivatives from Uvaria valderramensis J Nat Prod. 2014 Dec 26;77(12):2711-5. doi: 10.1021/np500538c. Epub 2014 Nov 5.
Kling B., Bücherl D., Palatzky P., Matysik FM, Decker M, Wegener J, Heilmann J. Flavonoids, flavonoid metabolites, and phenolic acids inhibit oxidative stress in the neuronal cell line HT-22 monitored by ECIS and MTT assay: A comparative study. Journal of Natural Products in press 2014.
Macabeo A.-PG, Lopez ADA, Schmidt S., Heilmann J., Dahse H.-M., Alejandro GJD, Franzblau SG Antitubercular and cytotoxic constituents from Goniothalamus gitingensis. Records of Natural Products 8, 41-45, 2013.
Scherübl R., Manns D., Heilmann J., Franz G. Comparison of HPLC versus HPTLC-densitometry for the quantification of chromone glucosides in Saposhnikoviae divaricatae radix. Chromatographia 76, 1537-1543, 2013.
Klein R., Müller E., Kraus B., Brunner G., Estrine B., Touraud D., Heilmann J., Kellermeier M., Kunz W. Biodegradability and cytotoxicity of Choline soaps on human cell lines: effects of chain length and the cation. RSC Advances 3, 23347-23354, 2013.
Knuth S, Abdelsalam RM, Khayyal MT, Schweda F, Heilmann J, Kees MG, Mair G, Kees F, Jürgenliemk G. Catechol conjugates are in-vivo metabolites of Salicis cartex. Planta Medica 79, 1489-1494, 2013.
Oberprieler C., Dietz L., Harlander C., Heilmann J. Molecular and phytochemical evidence for the taxonomic integrity of Salix alba, Salix fragilis and their hybrid S x rubens (Salicaceae) in mixed stands in SE Germany. Plant Systematics and Evolution 299, 1107-1118, 2013.7.
Barbic M., Willer EA, Rothenhöfer M., Heilmann J., Fürst R., Jürgenliemk G. Spirostanol saponins and esculin from Rusci rhizoma reduce the thrombin-induced hyperpermeability of endothelial cells. Phytochemistry 90, 106-113, 2013.
Nedialkov PT, Kokanova-Nedialkova Z., Bücherl D., Momekov G., Heilmann J., Nikolov S. 30-Normedicagenic acid glycosides from Chenopodium foliosum. Natural Products Communications 7, 1419-1422, 2012.
Schmidt S., Jürgenliemk G., Schmidt TJ, Skaltsa H., Heilmann J. Bi-, tri, and polycyclic acylphloroglucinols from Hypericum empetrifolium. Journal of Natural Products 75, 1697-1705.
Darras F., Kling B., Heilmann J., Decker M. Neuroprotective tri- and tetracyclic BChE inhibitors releasing reversible inhibitors upon carbamate transfer. Journal of Medicinal Chemistry Letters 3, 914-919, 2012.
Saugspier M., Dorn C., Czech B., Gehrig M., Heilmann J., Hellerbrand C. Hop bitter acids inhibit tumorgenicity of hepatocellular carcinoma cells in vitro. Oncology Reports 28, 1423-1428, 2012.
Dorn C., Massinger S., Wuzik A., Heilmann J, Hellerbrand C. Xanthohumol suppresses inflammatory response to warm ischemia-reperfusion induced liver injury. Experimental and Molecular Pathology 94, 10-16, 2013.
Vo HT, Nguyen N.-TT, Nguyen HT, Do KQ, Connolly JD, Maas G., Heilmann J., Werz UR, Pham HD, Nguyen L.-HD, Cytotoxic tetraoxygenated xanthones from the bark of Garcinia schomburgkiana, Phytochemistry Letters 5, 553-557, 2012.
Ulrich-Merzenich G., Kelber O., Koptina A., Freischmidt A., Heilmann J., Müller J., Zeitler H., Seidel MF, Ludwig M., Heinrich EU, Winterhoff H. Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine. Phytomedicine 19, 930-939, 2012.
Nguyen L.-TT, Nguyen HT, Harrison LJ, Barbič M., Brunner G., Heilmann J., Pham HD, Nguyen DM, Lien-Hoa D. Nguyen L.-HD Polyisoprenylated acylphloroglucinols and a polyisoprenylated tetracyclic xanthone from the bark of Calophyllum thorelii. Tetrahedron Letters 53, 4487-4493, 2012.
Rothenhöfer M., Scherübl R., Bernhardt G., Heilmann J., Buschauer A. Qualitative and quantitative analysis of hyaluronan oligosaccharides with high performance thin layer chromatography using reagent-free derivatization on amino-modified silica and electrospray ionization−quadrupole time -of-flight mass spectrometry coupling on normal phase. Journal of Chromatography A 1248, 169-177, 2012.
Chen X, Zenger K, Lupp A, Kling B, Heilmann J, Fleck C, Kraus B, Decker M pro-cognitive and hepatoprotective effects in vivo. Journal of Medicinal Chemistry 55, 5231-5242, 2012.
Dorn C., Heilmann J., Hellerbrand C. Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis. International Journal of Clinical and Experimental Pathology 5, 29-36, 2012.
Schmidt S., Jürgenliemk G., Skaltsa H., Heilmann J. Phloroglucinol derivatives from Hypericum empetrifolium with antiproliferative activity on endothelial cells. Phytochemistry 77, 218-225, 2012.
Win T., Htwe TT, Shwe HH, Heilmann J. Lavandulyl flavanones from the stems of Hypericum calycinum L. Chemistry and Biodiversity 9, 1198-1204, 2012.
Saugspier M., Dorn C., Thasler WE, Gehrig M., Heilmann J., Hellerbrand C. Hop bitter acids exhibit anti-fibrogenic effects on hepatic stellate cells in vitro. Experimental and Molecular Pathology 92, 222-229, 2012.
Ulrich-Merzenich G, Koptina A, Kelber O, Freischmidt A, Heilmann J, Müller J, Sadeghlar F, Zeitler H, Wagner H. Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine. Phytomedicine 19, 322-329, 2012.
Freischmidt A., Jürgenliemk G., Kraus B., Okpanyi SN, Müller J., Kelber O., Weiser D., Heilmann J. Contribution of flavonoids and catechol to the reduction of ICAM-1 expression in endothelial cells by a standardized willow bark extract. Phytomedicine 19, 245-252, 2012.
Motyl M., Kraus B., Heilmann J. Pitfalls in cell culture work with xanthohumol. Die Pharmazie 67, 91-94, 2012.
Wolff H, Motyl M, Hellerbrand C, Heilmann J, Kraus B. Xanthohumol uptake and intracellular kinetics in hepatocytes, hepatic stellate cells and intestinal cells. Journal of Agricultural and Food Chemistry 59, 12893-12901, 2011.
Kokanova-Nedialkova Z., Bücherl D., Nikolov S., Heilmann J., Nedialkov PT, Flavonol glycosides from Chenopodium foliosum Asch. Phytochemistry Letters 4, 367-371, 2011.
Bradacs G., Heilmann J., Weckerle CS Medicinal plant use in Vanuatu, South Pacific: A comparative ethnobotanical study of three islands. Journal of Ethnopharmacology 137, 434-448, 2011.
Sutor S., Heilmann J., Seifert, R. Impact of Fusion to Gαi2 and Co-Expression with RGS proteins on pharmacological properties of hCBR Journal of Pharmacy and Pharmacology 63, 1043-1055, 2011.
Oberprieler Ch., Hartl S., Schauer K. Heilmann, J. Morphological, phytochemical, and genetic variation in mixed stands and a hybrid swarm of Senecio germanicus and S. ovatus (Compositae, Senecioneae). Plant Systematics and Evolution 293, 177-191, 2011.
Macabeo APG, Vidar WS, Chen X, Decker M, Heilmann J, Wan B, Franzblau SG, Galvez EV, Aguinaldo MAM, Cordell GA Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa. European Journal of Medicinal Chemistry 46, 3118-3123, 2011.
Schempp H., Vogel S., Hückelhoven R., Heilmann J. Re-evaluation of superoxide scavenging capacity of xanthohumol. Free Radical Research 44, 1435-1444, 2010.
Geiger S., Nickl K., Schneider EH, Seifert R., Heilmann J. Establishment of recombinant cannabinoid receptor assays and characterization of several natural and synthetic ligands; Naunyn Schmiedeberg's Archives of Pharmacology 382, 177-191, 2010.
Barbic M, Macabeo APG, Kreft S, Heilmann J (2010) Cycloastrugenol glycosides from Astragalus illyricus. Biochemical Systematics and Ecology 38, 460-462.
Dorn C., Bataille F., Gaebele E., Heilmann J., Hellerbrand C. Xanthohumol feeding does not impair organ function and homeostasis in mice. Food and Chemical Toxicology 48, 1890-1897, 2010.
Oberprieler C., Barth A., Schwarz S., Heilmann J. Morphological and phytochemical variation, genetic structure, and phenology in an introgressive hybrid swarm of Senecio hercynicus and S. ovatus (Compositae, Senecioneae). Plant Systematics and Evolution 286, 153-166, 2010.
Rook Y., Schmidtke K.-U., Gaube F., Schepmann D., Wünsch B., Heilmann J., Lehmann J., Winckler T. Bivalent β-carbolines as potential multi-target anti-Alzheimer agents. Journal of Medicinal Chemistry 53, 3611-3617, 2010.
Kraus B., Wolff H., Elstner EF, Heilmann J. Hyperforin is a modulator of inducible nitric oxide synthase and phagocytosis in microglia and macrophages. Naunyn Schmiedeberg's Archives of Pharmacology 381, 541-553, 2010.
Vogel S., Barbic M., Jürgenliemk G., Heilmann J. Synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-Ring modifications on the pharmacological effect. European Journal of Medicinal Chemistry 45, 2206-2213, 2010.
Seemann A., Wallner T., Poschlod P., Heilmann J. Variation of sesquiterpene lactone contents in different Arnica montana populations: Influence of ecological parameters. Planta Medica 76, 837-842, 2010.
Dorn C., Weiss TS, Heilmann J., Hellerbrand C. Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells. International Journal of Oncology 36, 435-441, 2010.
Dorn C., Kraus B., Motyl M., Weiss TS, Gehrig M., Heilmann J., Hellerbrand C. Xanthohumol, a chalcone derived from hops, inhibits hepatic inflammation and fibrosis. Molecular Nutrition and Food Research 54, Suppl.2, S205-S213, 2010.
Shwe HH, Aye M, Sein MM, Htay KT, Kreitmeier P, Gertsch J, Reiser O, Heilmann J. Cytotoxic steroidal saponins from the rhizomes of Tacca integrifolia. Chemistry & Biodiversity 7, 610-623, 2010.
Bradacs G., Maes L., Heilmann J. In vitro cytotoxic, antiprotozoal and antimicrobial activities of medicinal plants from Vanuatu. Phytotherapy Research 24, 800-809, 2010.
Korte G., Dreiseitel A., Schreier P., Oehme A., Geiger S., Heilmann J., Sand PG Tea catechins' affinity for human cannabinoid receptors. Phytomedicine 17, 19-22, 2010.
Šlapetová T., Šmejkal K., Innocenti G., Dall'Acqua S., Heilmann J., Babula P. Hamzová T., Žemlička M. Glycosylated nervogenic acid derivatives from Liparis condylobulbon (Reichb.f.) leaves. Carbohydrate Research 344, 1770-44, 2009.
Hartkorn A., Hoffmann F., Ajamieh H., Vogel S., Heilmann J., Gerbes AL, Vollmar AM, Zahler S. Antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury. Journal of Natural Products 72, 1741-1747, 2009.
Vlachy N, Tourad D, Heilmann J, Kunz W (2009) Determining the cytotoxicity of catanionic surfactant mixtures on HeLa cells. Colloids Surf B Biointerfaces 70, 278-280, 2009.
Eggert M., Pellett P., Nickl K., Geiger S., Graetz, S., Seifert R., Heilmann J., König B. Synthesis and cannabinoid receptor activity of ketoalkenes from Echinacea pallida and non-natural analogues. Chemistry-A European Journal 14, 10978-10984 Transfer titles to Citavi project using this ISBN Transfer titles to Citavi project using this ISBN, 2008.
Vogel S., Heilmann J. Synthesis, cytotoxicity and anti-oxidative activity of minor prenylated chalcones from Humulus lupulus. Journal of Natural Products 71, 1237-1241, 2008.
Vlachy N., Merle C., Touraud D., Schmidt J., Talmon Y., Heilmann J., Kunz W. Spontaneous formation of bilayers and vesicles in mixtures of single-chain alkyl carboxylates: Effect of pH and aging and cytotoxicity studies. Langmuir 24, 9983-9988,
Fang L., Kraus B., Lehmann J., Heilmann J., Zhang Y., Decker M. Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates. Bioorganic and Medicinal Chemistry Letters 18, 2905-2909, 2008.
Vogel S., Ohmayer S., Brunner G., Heilmann J. Natural and non-natural prenylated chalcones: Synthesis, cytotoxicity and anti-oxidative activity. Bioorganic and Medicinal Chemistry 16, 4286-4293, 2008.
Nickl K., Gardner E., Geiger S., Heilmann J., Seifert R. Differential coupling of the human cannabinoid receptors hCB1R and hCB2R to the G-protein Galphai2beta1gamma2. Neuroscience Letters 447, 68-72, 2008.
Decker M., Kraus B., Heilmann J. Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties. Bioorganic and Medicinal Chemistry 16, 4252-4261, 2008.
Kraus B., Wolff H., Heilmann J., Elstner EF Influence of Hypericum perforatum extract and its single compounds on amyloid- mediated toxicity in microglial cells. Life Sciences 81, 884-894, 2007.
Karioti A., Skopeliti M., Tsitsilonis, O., Heilmann, J., Skaltsa H. Cytotoxicity and immunomodulating characteristics of labdane diterpenes from Marrubium cylleneum and Marrubium velutinum. Phytochemistry 68, 1587-1594, 2007.
Romagnoli R., Baraldi PG, Carrion MD, Cruz-Lopez O., Preti D., Tabrizi MA, Fruttarolo F., Heilmann J., Bermelo J., Estevez F. Hybrid molecules containing benzo[4,5]imidazo [1,2-d][1,2,4]thiadiazole and alpha-bromoacryloyl moieties as potent apoptosis inducers on humans myeloid leukemia cells. Bioorganic and Medicinal Chemistry Letters 17, 2844-2848, 2007.
Gousiadou C., Karioti A., Heilmann J., Skaltsa H. Iridoids from Scutellaria albida ssp. albida. Phytochemistry 68, 1799-1813, 2007.
Saraglou V., Karioti A., Heilmann J., Kypriotakis Z., Skaltsa H. Sesquiterpene lactones from Anthemis melanolepis. Helvetica Chimica Acta 90, 171-175, 2007.
Parakevi P., Lazari D., Karioti A., Souleles C., Heilmann J., Hajipavlou-Litina D., Skaltsa H. Phenolic compounds with antioxidant activity from Anthemis tinctoria L. subsp. tinctoria var. pallida DC. (Asteraceae). Journal for Natural Research C 62, 326-330, 2007.
Skaltsa H., Georgakopoulos P., Lazari D., Karioti A., Heilmann J., Sticher O., Constantinidis Th. Flavonoids as chemotaxonomic markers in the polymorphic Stachys swainsonii (Lamiaceae). Biochemical Systematics and Ecology 35, 317-320, 2007.
Çalış I., Birincioğlu SS, Kırmızıbekmez H., Pfeiffer B., Heilmann J. Secondary metabolites from Asphodelus aestivus. Journal of Natural Research 61b, 1304-1310, 2006.
Kelber O., Wittwer A., Lapke C., Kroll U., Weiser D., Okpanyi SN, Heilmann J. Ex vivo/in vitro absorption of STW 5 (Iberogast®) and its extract components. Phytomedicine 13 Suppl. 1, 107-113, 2006.
Romagnoli R, Baraldi PG, Iaconinoto MA, Carrion MD, Tabrizi MA, Gambari R, Borgatti M, Heilmann J. Synthesis and biological activity of alpha-bromoacryloyl lexitropsin conjugates. European Journal of Medicinal Chemistry 40, 1123-1128, 2005.
Karioti A., Heilmann J., Skaltsa H. Labdane diterpenes from Marrubium velutinum and Marrubium cylleneum, Phytochemistry 66, 1060-1066, 2005.
Karioti A., Heilmann J., Skaltsa H. Secondary metabolites from Marrubium velutinum, growing wild in Greece. Zeitschrift für Naturforschung 60b, 328-332, 2005.
Cottiglia F., Casu L., Bonsignore L., Casu M. Floris C., Leonti M., Gertsch J., Heilmann J. New cytotoxic prenylated isoflavonoids from Bituminaria morisiana. Planta Medica 71, 254-260, 2005.
Meremeti A., Karioti A., Skaltsa H., Heilmann J., Sticher O. Secondary metabolites from Stachys ionica. Biochemical Systematics and Ecology 32, 139-151, 2004.
Cottiglia F., Dhanapal B., Sticher O., Heilmann J. New chromanone acids with anti-bacterial activity from Calophyllum brasiliense. Journal of Natural Products 67, 537-541, 2004.
Gertsch J., Sticher O., Schmidt TJ, Heilmann J. Influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in Jurkat T-cells and human peripheral blood cells: Anti-inflammatory and cytotoxic effects. Biochemical Pharmacology 66, 2141-2153, 2003.
Hördegen P., Hertzberg H., Heilmann J., Gray D., Langhans W., Maurer V. The anthelmintic efficacy of five plant products against gastrointestinal trichostrongylids in artificially infected lambs. Veterinary Parasitology, 17, 56-60, 2003.
Hilmi F., Gertsch J., Bremner P., Valovic S., Heinrich M., Sticher O., Heilmann J. Cytotoxic versus anti-inflammatory effects in HeLa, Jurkat T and human peripheral blood cells caused by guaianolide-type sesquiterpene lactones. Bioorganic and Medicinal Chemistry 11, 3659-3663, 2003.
Winkelmann K., Metin S., Kypriotakis Z., Skaltsa H., Bosilij B., Heilmann J. Antibacterial and cytotoxic activity of prenylated bicyclic acylphloroglucinol derivatives from Hypericum amblycalyx. Zeitschrift für Naturforschung 58c, 527-532, 2003.
Karioti A., Skaltsa H., Heilmann J., Sticher O. Acylated flavonoid and phenylethanoid glycosides from Marrubium velutinum. Phytochemistry 64, 655-660, 2003.
Gertsch J., Thöni Tobler R., Brun R., Sticher O., Heilmann J. Antifungal, antiprotozoal, cytotoxic and properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum. Planta Medica 69, 413-419, 2003.
Akbay P., Çalis I. Heilmann J., Sticher, O. Ionone, iridoid and phenylethanoid glycosides from Ajuga salicifolia. Journal of Nature Research 58c, 177-180, 2003.
Akbay P., Çalis I., Heilmann J., Sticher O. New stigmastane sterols from Ajuga salicifolia. Journal of Natural Products 66, 461-465 2003.
Sagen A.-L., Gertsch J., Becker R., Heilmann J., Sticher O. Quinolizidine alkaloids from the curare plant Clathrothropis glaucophylla. Phytochemistry 61, 975-978, 2002.
Heilmann J., Winkelmann K., Sticher O. Studies on the antioxidant activity of phloroglucinol derivatives isolated from Hypericum species. Planta Medica 69, 193-201, 2003.
Mian P., Heilmann J., Bürgi H.-R., Sticher O. Biological screening of terrestrial and freshwater cyanobacteria for antimicrobial activity, brine shrimp lethality, and cytotoxicity. Pharmaceutical Biology 41, 243-247, 2003.
Hilmi F., Sticher O., Heilmann J. Further new cytotoxic sesquiterpene lactones from Warionia saharae. Planta Medica 69, 459-461, 2003.
Gertsch J., Güttinger M., Heilmann J., Sticher O. Curcumin differentially modulates mRNA profiles in Jurkat T and human mononuclear cells. Bioorganic and Medicinal Chemistry 11, 1057-1063, 2003.
Schmidt TJ, Heilmann J. Quantitative Structure-Cytotoxicity Relationships of sesquiterpene lactones derived from partial charge-based fractional Accessible Surface Area Descriptors (Q_frASAs). Quantitative Structure Activity Relationships 21, 277-287, 2002.
Akbay P., Çalıs I., Gertsch J., Heilmann J., Zerbe O., Sticher O. Novel antileukemic sterol glycosides from Ajuga salicifolia. Helvetica Chimica Acta 85, 1930-1942, 2002.
Prinz S., Müllner U., Heilmann J., Winkelmann K., Sticher O., Haslinger E., Hüfner A. New oxidation products of abietic acid and its methyl ester. Journal of Natural Products 65, 1530-1534, 2002.
Hilmi F., Sticher O., Heilmann J. New cytotoxic 6,7-cis and 6,7-trans configured guaianolides from Warionia saharae. Journal of Natural Products 65, 523-526, 2002.
Gertsch J., Güttinger M., Sticher O., Heilmann J. Relative quantification of mRNA levels in Jurkat T cells with RT – real time – PCR: New possibilities for the screening of anti-inflammatory and cytotoxic natural compounds. Pharmaceutical Research 19, 1235-1242, 2002.
Jager H., Meinel L., Dietz B., Lapke C., Bauer R., Merkle HP, Heilmann J. Transport of alkamides from Echinacea species through Caco-2 monolayers. Planta Medica 68, 469-471, 2002.
Winkelmann K., Heilmann J., Zerbe O., Rali T., Sticher O. Further prenylated bi- and tricyclic phloroglcinol derivatives from Hypericum papuanum. Helvetica Chimica Acta 84, 3380-3392, 2001.
Heilmann J., Wasescha MR, Schmidt TJ. The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide type sesquiterpene lactones against KB cells. Bioorganic and Medicinal Chemistry 9, 2189-2194, 2001.
Heilmann J., Brun R., Mayr S., Rali T., Sticher O. Minor cytotoxic and antibacterial compounds from the rhizomes of Amomum aculeatum. Phytochemistry 57, 1281-1285, 2001.
Çalis I., Heilmann J., Tasdemir D., Linden A., Ireland C., Sticher O. Flavonoid, iridoid and lignan glycosides from Putoria calabrica. Journal of Natural Products 64, 961-964, 2001.
Dietz B., Heilmann J., Bauer R. Absorption of dodeca-2E, 4E, 8Z, 10 E/Z-tetraenoic acid isobutylamides after oral application of Echinacea purpurea tincture. Planta Medica 67, 863-864, 2001.
Winkelmann K., Heilmann J., Zerbe O., Rali T., Sticher O. New prenylated bi- and tricyclic phloroglucinol derivatives from Hypericum papuanum. Journal of Natural Products 64, 701-706, 2001.
Resch M., Heilmann J., Steigel A., Bauer R. Further phenols and polyacetylenes from the rhizomes of Atractylodes lancea and their anti-inflammatory activity. Planta Medica 67, 437-442, 2001.
Heilmann J., Mayr S., Brun R., Rali T., Sticher O. Antiprotozoal activity and cytotoxicity of novel 1,7-dioxa-dispiro[5.1.5.2]pentadeca-9,12-dien-11-one derivatives from Amomum aculeatum. Helvetica Chimica Acta 83, 2939-2945, 2000.
Liu H., Heilmann J., Rali T., Sticher O. New Tirucallane-type triterpenes from Dysoxylum variabile. Journal of Natural Products 64, 159-163, 2001.
Jaki B., Zerbe O., Heilmann J., Sticher, O. Two novel cyclic peptides with antifungal activity from the cyanobacterium Tolypothrix byssoidea (EAWAG 195). Journal of Natural Products 64, 154-158, 2001.
Wirz A., Simmen U., Heilmann J., Çalis I., Meier B., Sticher O. Bisanthraquinone glycosides of Hypericum perforatum with binding inhibition to CRH-1 receptors. Phytochemistry 55, 941-947, 2000.
Jaki B., Heilmann J., Sticher O. New antibacterial metabolites from the cyanobacterium Nostoc commune (EAWAG 122b). Journal of Natural Products 63, 1283-1285, 2000.
Quadri-Spinelli T., Heilmann J., Rali T., Sticher O. Bioactive coumarin derivatives from the fern Cyclosorus interruptus. Planta Medica 66, 728-733, 2000.
Schühly W., Heilmann J., Çalis I., Sticher O. Novel triterpene saponins from Zizyphus joazeiro. Helvetica Chimica Acta 83, 1509-1515, 2000.
Heilmann J., Çalis I, Kirmizbekmez H., Schühly W., Harput S., Sticher O. Radical scavenger activity of phenylethanoid glycosides in FMLP stimulated human polymorphonuclear leukocytes – structure activity relationships. Planta Medica 66, 746-748, 2000.
Schmidt TJ, Heilmann J. Tetrahydrofuran lignans from Illicium floridanum and their activity in a luminol enhanced chemiluminescence assay. Planta Medica 66,749-751, 2000.
Ankli A., Heilmann J., Heinrich M., Sticher O. Cytotoxic cardenolides and anti-bacterial terpenoids from Crossopetalum gaumeri. Phytochemistry 54,531-537, 2000.
Winkelmann K., Heilmann J., Zerbe O., Rali T., Sticher O. New phloroglucinol derivatives from Hypericum papuanum. Journal of Natural Products 63, 104-108, 2000.
Jaki B., Orjala J., Heilmann J., Vogler B., Sticher O. Novel extracellular diterpenoids with biological activity from cyanobacterium Nostoc commune. Journal of Natural Products 63, 339-343, 2000.
Schühly W., Heilmann J., Çalis I., Sticher, O. New triterpenoids with antibacterial activity from Zizyphus joazeiro. Planta Medica 65, 740-743, 1999.
Heilmann J., Müller E., Merfort I. Flavonoid glucosides and dicaffeoylquinic acids from flowerheads of Buphthalmum salicifolium. Phytochemistry 51, 713-718, 1999.
Lobitz GO, Heilmann J., Zschocke S., Tamayo-Castillo G., Bauer R., Merfort I. Bornyl cinnamate derivatives with anti-inflammatory activity from Verbesina turbacensis. Pharmaceutical and Pharmacological Letters 8, 115-118, 1998.
Heilmann J., Resch M., Bauer R. Antioxidant activity of constituents from Atractylodes lancea. Pharmaceutical and Pharmacological Letters 8, 69-71, 1998.
Merfort I., Heilmann J., Weiss M., Pietta P., Gardana C. Radical scavenger activity of three flavonoid metabolites studied by inhibition of chemiluminescence in human PMNs. Planta Medica 62, 289-292, 1996.
Heilmann J., Merfort I., Weiss M. Radical scavenger activity of different 3',4'-dihydroxy-flavonols and 1,5-dicaffeoylquinic acid studied by inhibition of chemiluminescence. Planta Medica 61, 435-438, 1995.
Merfort I., Heilmann J., Hagedorn-Leweke U., Lippold BC In vivo skin penetration studies of chamomile flavones. Pharmazie 49, 509-511, 1994.

I.b. Reviews

Heilmann J., Wirkstoffe auf der Basis von biologisch aktiven Naturstoffen, Chemie in unserer Zeit 41, 376-389, 2007.
v. Raison J., Heilmann J., Merfort I., Schmidt T.J., Brock F.E., Leven W., Bomme U., Bauer R. Arnika - Arzneipflanze mit Tradition und Zukunft, Zeitschrift für Phytotherapie 21, 39-54, 2000.
Heilmann J., Merfort I. Aktueller Kenntnisstand zum Metabolismus von Flavonoiden. II. Resorption und Metabolismus von Flavonen, Flavanonen, Flavanen, Proanthocyanidinen und Isoflavonoiden, Pharmazie in unserer Zeit 27, 173-183, 1998.
Heilmann J., Merfort I. Aktueller Kenntnisstand zum Metabolismus von Flavonoiden. I. Resorption und Metabolismus von Flavonolen, Pharmazie in unserer Zeit 27, 58-65, 1998.
Merfort I., Heilmann J. Bericht über die 41. Jahrestagung der Gesellschaft für Arzneipflanzenforschung in Düsseldorf, Pharmazie in unserer Zeit 22, 323-328, 1993.

I.c. Buchkapitel

Functions of plant secondary metabolites and their applications in biotechnology, Annual Plant Reviews, Volume 3 (1999/2010), Edited by Michael Wink, Sheffield Academic Press Ltd.. Medical applications of plant secondary metabolites.