Publications

2023

2023

Vonbrunn E, Büttner-Herold M, Amann K, Daniel C.
Complement Inhibition in Kidney Transplantation: Where Are We Now?
BioDrugs. 2023 Jan;37(1):5-19. doi: 10.1007/s40259-022-00567-1. Epub 2022 Dec 13. PMID: 36512315; PMCID: PMC9836999.
PubMed

Schanz M, Kimmel M, Alscher MD, Amann K, Daniel C.
TIMP-2 and IGFBP7 in human kidney biopsies in renal disease.
Clin Kidney J. 2023 Jan 16;16(9):1434-1446. doi: 10.1093/ckj/sfad010. PMID: 37664566; PMCID: PMC10468751.
PubMed

Kraus A, Lüdke A, Teschemacher B, Skoczynski K, Buchholz B.
In vitro cyst puncture and injury-induced tubule formation using renal epithelial cells.
STAR Protoc. 2023 Jan 19;4(1):101874. doi: 10.1016/j.xpro.2022.101874. Epub ahead of print. PMID: 36856763; PMCID: PMC10037192.
PubMed

Schreiber R, Talbi K, Ousingsawat J, Kunzelmann K.
A TMEM16J variant leads to dysregulated cytosolic calcium which may lead to renal disease.
FASEB J. 2023 Jan;37(1):e22683. doi: 10.1096/fj.202200968R. PMID: 36520003.
PubMed

Côrte-Real BF, Hamad I, Arroyo Hornero R, Geisberger S, Roels J, Van Zeebroeck L, Dyczko A, van Gisbergen MW, Kurniawan H, Wagner A, Yosef N, Weiss SNY, Schmetterer KG, Schröder A, Krampert L, Haase S, Bartolomaeus H, Hellings N, Saeys Y, Dubois LJ, Brenner D, Kempa S, Hafler DA, Stegbauer J, Linker RA, Jantsch J, Müller DN, Kleinewietfeld M.
Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs.
Cell Metab. 2023 Feb 7;35(2):299-315.e8. doi: 10.1016/j.cmet.2023.01.009. PMID: 36754020.
PubMed

Dagorn PG, Buchholz B, Kraus A, Batchuluun B, Bange H, Blockken L, Steinberg GR, Moller DE, Hallakou-Bozec S.
A novel direct adenosine monophosphate kinase activator ameliorates disease progression in preclinical models of Autosomal Dominant Polycystic Kidney Disease.
Kidney Int. 2023 Feb 18:S0085-2538(23)00122-9. doi: 10.1016/j.kint.2023.01.026. Epub ahead of print. PMID: 36804411.
PubMed

Donhauser FJ, Zimmermann ME, Steinkirchner AB, Wiegrebe S, Dietl A, Brandl C, Burkhardt R, Gessner A, Schweda F, Bergler T, Schäffner E, Böger CA, Kronenberg F, Luchner A, Stark KJ, Heid IM.
Cardiovascular Risk Factor Control in 70- to 95-Year-Old Individuals: Cross-Sectional Results from the Population-Based AugUR Study.
J Clin Med. 2023 Mar 7;12(6):2102. doi: 10.3390/jcm12062102. PMID: 36983106; PMCID: PMC10054695.
PubMed

Heinl ES, Broeker KA, Lehrmann C, Heydn R, Krieger K, Ortmaier K, Tauber P, Schweda F.
Localization of natriuretic peptide receptors A, B, and C in healthy and diseased mouse kidneys.
Pflugers Arch. 2023 Mar;475(3):343-360. doi: 10.1007/s00424-022-02774-9. Epub 2022 Dec 8. PMID: 36480070; PMCID: PMC9908653.
PubMed

Sinha F, Federlein A, Biesold A, Schwarzfischer M, Krieger K, Schweda F, Tauber P.
Empagliflozin increases kidney weight due to increased cell size in the proximal tubule S3 segment and the collecting duct.
Front Pharmacol. 2023 Mar 23;14:1118358. doi: 10.3389/fphar.2023.1118358. PMID: 37033639; PMCID: PMC10076569.
PubMed

Grampp S, Krüger R, Lauer V, Uebel S, Knaup KX, Naas J, Höffken V, Weide T, Schiffer M, Naas S, Schödel J.
Hypoxia hits APOL1 in the kidney.
Kidney Int. 2023 Apr 23:S0085-2538(23)00266-1. doi: 10.1016/j.kint.2023.03.035. Epub ahead of print. PMID: 37098381.
PubMed

Grampp S, Kraus A, Skoczynski K, Schiffer M, Krüger R, Naas S, Schödel J, Buchholz B.
Hypoxia induces polycystin-1 expression in the renal epithelium.
R. Soc. OpenSci. 2023 10: 220992.
https://doi.org/10.1098/rsos.220992

Centeio R, Cabrita I, Schreiber R, Kunzelmann K.
TMEM16A/F support exocytosis but do not inhibit Notch-mediated goblet cell metaplasia of BCi-NS1.1 human airway epithelium.
Front Physiol. 2023 May 9;14:1157704. doi: 10.3389/fphys.2023.1157704. PMID: 37234411; PMCID: PMC10206426.
PubMed

Herold JM, Nano J, Gorski M, Winkler TW, Stanzick KJ, Zimmermann ME, Brandl C, Peters A, Koenig W, Burkhardt R, Gessner A, Heid IM, Gieger C, Stark KJ.
Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly - comparative results from the KORA and AugUR study.
BMC Genom Data. 2023 May 25;24(1):28. doi: 10.1186/s12863-023-01130-9. PMID: 37231333; PMCID: PMC10210501.
PubMed

Naas S, Krüger R, Knaup KX, Naas J, Grampp S, Schiffer M, Wiesener M, Schödel J.
Hypoxia controls expression of kidney-pathogenic MUC1 variants.
Life Sci Alliance. 2023 Jun 14;6(9):e202302078. doi: 10.26508/lsa.202302078. PMID: 37316299; PMCID: PMC10267510.
PubMed

Böhme R, Daniel C, Ferrazzi F, Angeloni M, Ekici AB, Winkler TH, Hilgers KF, Wellmann U, Voll RE, Amann K.
Cardiovascular changes in the NZB/W F1 mouse model of lupus nephritis.
Front Cardiovasc Med. 2023 Jul 24;10:1182193. doi: 10.3389/fcvm.2023.1182193. PMID: 37554366; PMCID: PMC10405627.
PubMed

Cazorla-Vázquez S, Kösters P, Bertz S, Pfister F, Daniel C, Dedden M, Zundler S, Jobst-Schwan T, Amann K, Engel FB.
Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish, Mouse, and Human Kidney.
Cells. 2023 Aug 2;12(15):1988. doi: 10.3390/cells12151988. PMID: 37566066; PMCID: PMC10417176.
PubMed

Kunzelmann K, Ousingsawat J, Kraus A, Park JH, Marquardt T, Schreiber R, Buchholz B.
Pathogenic Relationships in Cystic Fibrosis and Renal Diseases: CFTR, SLC26A9 and Anoctamins.
Int J Mol Sci. 2023 Aug 26;24(17):13278. doi: 10.3390/ijms241713278. PMID: 37686084; PMCID: PMC10487509.
PubMed

Talbi K, Ousingsawat J, Centeio R, Schreiber R, Kunzelmann K.
KCNE1 does not shift TMEM16A from a Ca2+ dependent to a voltage dependent Cl- channel and is not expressed in renal proximal tubule.
Pflugers Arch. 2023 Aug;475(8):995-1007. doi: 10.1007/s00424-023-02829-5. Epub 2023 Jul 13. PMID: 37442855; PMCID: PMC10359377.
PubMed

Naas S, Schiffer M, Schödel J.
Hypoxia and renal fibrosis.
Am J Physiol Cell Physiol. 2023 Oct 1;325(4):C999-C1016. doi: 10.1152/ajpcell.00201.2023. Epub 2023 Sep 4. PMID: 37661918.
PubMed

Wahida A, Schmaderer C, Büttner-Herold M, Branca C, Donakonda S, Haberfellner F, Torrez C, Schmitz J, Schulze T, Seibt T, Öllinger R, Engleitner T, Haller B, Steiger K, Günthner R, Lorenz G, Yabal M, Bachmann Q, Braunisch MC, Moog P, Matevossian E, Aßfalg V, Thorban S, Renders L, Späth MR, Müller RU, Stippel DL, Weichert W, Slotta-Huspenina J, von Vietinghoff S, Viklicky O, Green DR, Rad R, Amann K, Linkermann A, Bräsen JH, Heemann U, Kemmner S.
High RIPK3 expression is associated with a higher risk of early kidney transplant failure.
iScience. 2023 Sep 17;26(10):107879. doi: 10.1016/j.isci.2023.107879. PMID: 37868627; PMCID: PMC10585402.
PubMed

Sinha F, Schweda F, Maier LS, Wagner S.
Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation.
International Journal of Molecular Sciences. 2023; 24(18):14198.
https://doi.org/10.3390/ijms241814198

Stanzick KJ, Stark KJ, Gorski M, Schödel J, Krüger R, Kronenberg F, Warth R, Heid IM, Winkler TW.
KidneyGPS: a user-friendly web application to help prioritize kidney function genes and variants based on evidence from genome-wide association studies.
BMC Bioinformatics. 2023 Sep 21;24(1):355. doi: 10.1186/s12859-023-05472-0.
Pubmed

Meindl K, Issler N, Afonso S, Cebrian-Serrano A, Müller K, Sterner C, Othmen H, Tegtmeier I, Witzgall R, Klootwijk E, Davies B, Kleta R, Warth R.
A missense mutation in Ehd1 associated with defective spermatogenesis and male infertility.
Front Cell Dev Biol. 2023 Oct 12;11:1240558. doi: 10.3389/fcell.2023.1240558.
Pubmed

Gaupp C, Schmid B, Tripal P, Edwards A, Daniel C, Zimmermann S, Goppelt-Struebe M, Willam C, Rosen S, Schley G.
Reconfiguration and loss of peritubular capillaries in chronic kidney disease.
Sci Rep. 2023 Nov 11;13(1):19660. doi: 10.1038/s41598-023-46146-4. PMID: 37952029; PMCID: PMC10640592.
PubMed

Ousingsawat J, Talbi K, Gómez-Martín H, Koy A, Fernández-Jaén A, Tekgül H, Serdaroğlu E, Schreiber R, Ortigoza-Escobar JD, Kunzelmann K.
Broadening the clinical spectrum: molecular mechanisms and new phenotypes of ANO3-dystonia.
Brain. 2023 Dec 11:awad412. doi: 10.1093/brain/awad412. Epub ahead of print. PMID: 38079528.
PubMed

Kunzelmann K, Centeio R, Ousingsawat J, Talbi K, Seidler U, Schreiber R.
SLC26A9 in airways and intestine: secretion or absorption?
Channels (Austin). 2023 Dec;17(1):2186434. doi: 10.1080/19336950.2023.2186434. PMID: 36866602; PMCID: PMC9988340.
PubMed

Krampert L, Ossner T, Schröder A, Schatz V, Jantsch J.
Simultaneous Increases in Intracellular Sodium and Tonicity Boost Antimicrobial Activity of Macrophages.
Cells. 2023 Dec 11;12(24):2816. doi: 10.3390/cells12242816. PMID: 38132136; PMCID: PMC10741518.
PubMed

2022

2022

Fuchs MAA, Schrankl J, Leupold C, Wagner C, Kurtz A, Broeker K.
Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice.
Am J Physiol Renal Physiol. 2022 Jan 17. doi: 10.1152/ajprenal.00414.2021. Epub ahead of print. PMID: 35037469.
PubMed

Wörner S, Bohnert BN, Wörn M, Xiao M, Janessa A, Birkenfeld AL, Amann K, Daniel C, Artunc F.
Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice.
Acta Pharmacol Sin. 2022 Jan;43(1):111-120. doi: 10.1038/s41401-021-00628-1. Epub 2021 Mar 23. PMID: 33758357; PMCID: PMC8724274.
PubMed

Niederreiter J, Eck C, Ries T, Hartmann A, Märkl B, Büttner-Herold M, Amann K, Daniel C.
Complement Activation via the Lectin and Alternative Pathway in Patients With Severe COVID-19. Front Immunol. 2022 Feb 2;13:835156. doi: 10.3389/fimmu.2022.835156. PMID: 35237273; PMCID: PMC8884149.
PubMed

Arzt M, Drzymalski MA, Ripfel S, Meindl S, Biedermann A, Durczok M, Keller K, Mustroph J, Katz S, Tafelmeier M, Lebek S, Flörchinger B, Camboni D, Wittmann S, Backs J, Schmid C, Maier LS, Wagner S.
Enhanced Cardiac CaMKII Oxidation and CaMKII-Dependent SR Ca Leak in Patients with Sleep-Disordered Breathing.
Antioxidants (Basel). 2022 Feb 8;11(2):331. doi: 10.3390/antiox11020331. PMID: 35204213; PMCID: PMC8868143.
PubMed

Issler N, Afonso S, Weissman I, Jordan K, Cebrian-Serrano A, Meindl K, Dahlke E, Tziridis K, Yan G, Robles-López JM, Tabernero L, Patel V, Kesselheim A, Klootwijk ED, Stanescu HC, Dumitriu S, Iancu D, Tekman M, Mozere M, Jaureguiberry G, Outtandy P, Russell C, Forst AL, Sterner C, Heinl ES, Othmen H, Tegtmeier I, Reichold M, Schiessl IM, Limm K, Oefner P, Witzgall R, Fu L, Theilig F, Schilling A, Shuster Biton E, Kalfon L, Fedida A, Arnon-Sheleg E, Ben Izhak O, Magen D, Anikster Y, Schulze H, Ziegler C, Lowe M, Davies B, Böckenhauer D, Kleta R, Falik Zaccai TC, Warth R.
A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness.
J Am Soc Nephrol. 2022 Feb 11: epub ahead of print. doi: 10.1681/ASN.2021101312.
Pubmed
Editorial

Wester M, Pec J, Lebek S, Fisser C, Debl K, Hamer O, Poschenrieder F, Buchner S, Maier LS, Arzt M, Wagner S.
Sleep-Disordered Breathing Is Associated With Reduced Left Atrial Strain Measured by Cardiac Magnetic Resonance Imaging in Patients After Acute Myocardial Infarction.
Front Med (Lausanne). 2022 Feb 16;9:759361. doi: 10.3389/fmed.2022.759361. PMID: 35252229; PMCID: PMC8888827.
PubMed

Broeker KAE, Fuchs MAA, Schrankl J, Lehrmann C, Schley G, Todorov VT, Hugo C, Wagner C, Kurtz A.
Prolyl-4-hydroxylases 2 and 3 control erythropoietin production in renin-expressing cells of mouse kidneys.
J Physiol. 2022 Feb;600(3):671-694. doi: 10.1113/JP282615. Epub 2021 Dec 27. PMID: 34863041.
PubMed

Baumgartner A, Reichelt-Wurm S, Gronwald W, Samol C, Schröder JA, Fellner C, Holler K, Steege A, Putz FJ, Oefner PJ, Banas B, Banas MC.
Assessment of Physiological Rat Kidney Ageing-Implications for the Evaluation of Allograft Quality Prior to Renal Transplantation.
Metabolites. 2022 Feb 8;12(2):162. doi: 10.3390/metabo12020162. PMID: 35208236; PMCID: PMC8875225.
PubMed

Protze J, Naas S, Krüger R, Stöhr C, Kraus A, Grampp S, Wiesener M, Schiffer M, Hartmann A, Wullich B, Schödel J.
The renal cancer risk allele at 14q24.2 activates a novel hypoxia-inducible transcription factor-binding enhancer of DPF3 expression.
J Biol Chem. 2022 Mar;298(3):101699. doi: 10.1016/j.jbc.2022.101699. Epub 2022 Feb 8. PMID: 35148991; PMCID: PMC8897700.
PubMed

Kjaergaard AD, Teumer A, Witte DR, Stanzick KJ, Winkler TW, Burgess S, Ellervik C.
Obesity and Kidney Function: A Two-Sample Mendelian Randomization Study.
Clin Chem. 2022 Mar 4;68(3):461-472. doi: 10.1093/clinchem/hvab249. PMID: 34922334.
PubMed

Lo J, Forst AL, Warth R, Zdebik AA.
EAST/SeSAME Syndrome and Beyond: The Spectrum of Kir4.1- and Kir5.1-Associated Channelopathies.
Front Physiol. 2022 Mar 15;13:852674. doi: 10.3389/fphys.2022.852674.
Pubmed

Vonbrunn E, Angeloni M, Büttner-Herold M, Müller-Deile J, Heller K, Bleich E, Söllner S, Amann K, Ferrazzi F, Daniel C.
Can Gene Expression Analysis in Zero-Time Biopsies Predict Kidney Transplant Rejection?
Front Med (Lausanne). 2022 Mar 30;9:793744. doi: 10.3389/fmed.2022.793744. PMID: 35433772; PMCID: PMC9005644.
PubMed

Baier MJ, Wagner S, Hupf J, Evert K, Evert M, Sossalla S, Jungbauer C, Maier LS, Neef S, Mustroph J.
Cardiac iron overload promotes cardiac injury in patients with severe COVID-19.
Infection. 2022 Apr;50(2):547-552. doi: 10.1007/s15010-021-01722-6. Epub 2021 Oct 20. PMID: 34669163; PMCID: PMC8527292.
PubMed

Sure F, Bertog M, Afonso S, Diakov A, Rinke R, Madej MG, Wittmann S, Gramberg T, Korbmacher C, Ilyaskin AV.
Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel's γ-subunit.
J Biol Chem. 2022 Apr 30:102004. doi: 10.1016/j.jbc.2022.102004 . Epub ahead of print. PMID: 35504352 .
PubMed

Scholz JK, Kraus A, Lüder D, Skoczynski K, Schiffer M, Grampp S, Schödel J, Buchholz B.
Loss of Polycystin-1 causes cAMP-dependent switch from tubule to cyst formation.
iScience. 2022 May 5;25(6):104359. doi: 10.1016/j.isci.2022.104359. PMID: 35620436; PMCID: PMC9127160.
PubMed

Winkler TW, Rasheed H, Teumer A, Gorski M, Rowan BX, Stanzick KJ, Thomas LF, Tin A, Hoppmann A, Chu AY, Tayo B, Thio CHL, Cusi D, Chai JF, Sieber KB, Horn K, Li M, Scholz M, Cocca M, Wuttke M, van der Most PJ, Yang Q, Ghasemi S, Nutile T, Li Y, Pontali G, Günther F, Dehghan A, Correa A, Parsa A, Feresin A, de Vries APJ, Zonderman AB, Smith AV, Oldehinkel AJ, De Grandi A, Rosenkranz AR, Franke A, Teren A, Metspalu A, Hicks AA, Morris AP, Tönjes A, Morgan A, Podgornaia AI, Peters A, Körner A, Mahajan A, Campbell A, Freedman BI, Spedicati B, Ponte B, Schöttker B, Brumpton B, Banas B, Krämer BK, Jung B, Åsvold BO, Smith BH, Ning B, Penninx BWJH, Vanderwerff BR, Psaty BM, Kammerer CM, Langefeld CD, Hayward C, Spracklen CN, Robinson-Cohen C, Hartman CA, Lindgren CM, Wang C, Sabanayagam C, Heng CK, Lanzani C, Khor CC, Cheng CY, Fuchsberger C, Gieger C, Shaffer CM, Schulz CA, Willer CJ, Chasman DI, Gudbjartsson DF, Ruggiero D, Toniolo D, Czamara D, Porteous DJ, Waterworth DM, Mascalzoni D, Mook-Kanamori DO, Reilly DF, Daw EW, Hofer E, Boerwinkle E, Salvi E, Bottinger EP, Tai ES, Catamo E, Rizzi F, Guo F, Rivadeneira F, Guilianini F, Sveinbjornsson G, Ehret G, Waeber G, Biino G, Girotto G, Pistis G, Nadkarni GN, Delgado GE, Montgomery GW, Snieder H, Campbell H, White HD, Gao H, Stringham HM, Schmidt H, Li H, Brenner H, Holm H, Kirsten H, Kramer H, Rudan I, Nolte IM, Tzoulaki I, Olafsson I, Martins J, Cook JP, Wilson JF, Halbritter J, Felix JF, Divers J, Kooner JS, Lee JJ, O'Connell J, Rotter JI, Liu J, Xu J, Thiery J, Ärnlöv J, Kuusisto J, Jakobsdottir J, Tremblay J, Chambers JC, Whitfield JB, Gaziano JM, Marten J, Coresh J, Jonas JB, Mychaleckyj JC, Christensen K, Eckardt KU, Mohlke KL, Endlich K, Dittrich K, Ryan KA, Rice KM, Taylor KD, Ho K, Nikus K, Matsuda K, Strauch K, Miliku K, Hveem K, Lind L, Wallentin L, Yerges-Armstrong LM, Raffield LM, Phillips LS, Launer LJ, Lyytikäinen LP, Lange LA, Citterio L, Klaric L, Ikram MA, Ising M, Kleber ME, Francescatto M, Concas MP, Ciullo M, Piratsu M, Orho-Melander M, Laakso M, Loeffler M, Perola M, de Borst MH, Gögele M, Bianca M, Lukas MA, Feitosa MF, Biggs ML, Wojczynski MK, Kavousi M, Kanai M, Akiyama M, Yasuda M, Nauck M, Waldenberger M, Chee ML, Chee ML, Boehnke M, Preuss MH, Stumvoll M, Province MA, Evans MK, O'Donoghue ML, Kubo M, Kähönen M, Kastarinen M, Nalls MA, Kuokkanen M, Ghanbari M, Bochud M, Josyula NS, Martin NG, Tan NYQ, Palmer ND, Pirastu N, Schupf N, Verweij N, Hutri-Kähönen N, Mononen N, Bansal N, Devuyst O, Melander O, Raitakari OT, Polasek O, Manunta P, Gasparini P, Mishra PP, Sulem P, Magnusson PKE, Elliott P, Ridker PM, Hamet P, Svensson PO, Joshi PK, Kovacs P, Pramstaller PP, Rossing P, Vollenweider P, van der Harst P, Dorajoo R, Sim RZH, Burkhardt R, Tao R, Noordam R, Mägi R, Schmidt R, de Mutsert R, Rueedi R, van Dam RM, Carroll RJ, Gansevoort RT, Loos RJF, Felicita SC, Sedaghat S, Padmanabhan S, Freitag-Wolf S, Pendergrass SA, Graham SE, Gordon SD, Hwang SJ, Kerr SM, Vaccargiu S, Patil SB, Hallan S, Bakker SJL, Lim SC, Lucae S, Vogelezang S, Bergmann S, Corre T, Ahluwalia TS, Lehtimäki T, Boutin TS, Meitinger T, Wong TY, Bergler T, Rabelink TJ, Esko T, Haller T, Thorsteinsdottir U, Völker U, Foo VHX, Salomaa V, Vitart V, Giedraitis V, Gudnason V, Jaddoe VWV, Huang W, Zhang W, Wei WB, Kiess W, März W, Koenig W, Lieb W, Gao X, Sim X, Wang YX, Friedlander Y, Tham YC, Kamatani Y, Okada Y, Milaneschi Y, Yu Z; Lifelines cohort study; DiscovEHR/MyCode study; VA Million Veteran Program, Stark KJ, Stefansson K, Böger CA, Hung AM, Kronenberg F, Köttgen A, Pattaro C, Heid IM.
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.
Commun Biol. 2022 Jun 13;5(1):580. doi: 10.1038/s42003-022-03448-z. PMID: 35697829; PMCID: PMC9192715.
PubMed

Heinz V, Güler G, Leone V, Madej MG, Maksimov S, Gärtner RM, Rudi O, Hamdi F, Kastritis PL, Mäntele W, Krämer R, Forrest LR, Perez C, Ziegler C.
Osmotic stress response in BetP: How lipids and K+ team up to overcome downregulation.
bioRxiv 2022.06.02.493408; doi: https://doi.org/10.1101/2022.06.02.493408

Bichlmayer EM, Mahl L, Hesse L, Pion E, Haller V, Moehwald A, Hackl C, Werner JM, Schlitt HJ, Schwarz S, Kainz P, Brochhausen C, Groeger C, Steger F, Kölbl O, Daniel C, Amann K, Kraus A, Buchholz B, Aung T, Haerteis S.
A 3D In Vivo Model for Studying Human Renal Cystic Tissue and Mouse Kidney Slices. Cells. 2022 Jul 22;11(15):2269. doi: 10.3390/cells11152269. PMID: 35892566; PMCID: PMC9330914.
PubMed

Moulin S, Thomas A, Wagner S, Arzt M, Dubouchaud H, Lamarche F, Bouyon S, Vial G, Godin-Ribuot D, Pépin JL, Arnaud C, Belaidi E.
Intermittent Hypoxia-Induced Cardiomyocyte Death Is Mediated by HIF-1 Dependent MAM Disruption.
Antioxidants (Basel). 2022 Jul 27;11(8):1462. doi: 10.3390/antiox11081462. PMID: 36009181; PMCID: PMC9405320.
PubMed

Diakov A, Nesterov V, Dahlmann A, Korbmacher C.
Two adjacent phosphorylation sites in the C-terminus of the channel's α-subunit have opposing effects on epithelial sodium channel (ENaC) activity.
Pflugers Arch. 2022 Jul;474(7):681-697. doi: 10.1007/s00424-022-02693-9. Epub 2022 May 8. Erratum in: Pflugers Arch. 2022 Jun 9;: PMID: 35525869; PMCID: PMC9192390.
PubMed

Wopperer FJ, Knaup KX, Stanzick KJ, Schneider K, Jobst-Schwan T, Ekici AB, Uebe S, Wenzel A, Schliep S, Schürfeld C, Seitz R, Bernhardt W, Gödel M, Wiesener A, Popp B, Stark KJ, Gröne HJ, Friedrich B, Weiß M, Basic-Jukic N, Schiffer M, Schröppel B, Huettel B, Beck BB; Genomics England Research Consortium, Sayer JA, Ziegler C, Büttner-Herold M, Amann K, Heid IM, Reis A, Pasutto F, Wiesener MS.
Diverse molecular causes of unsolved autosomal dominant tubulointerstitial kidney diseases.
Kidney Int. 2022 Aug;102(2):405-420. doi: 10.1016/j.kint.2022.04.031. Epub 2022 May 26. PMID: 35643372.
PubMed

Skoczynski K, Kraus A, Büttner-Herold M, Amann K, Schiffer M, Hermann K, Herrnberger L, Tamm ER, Buchholz B.
The extracellular matrix protein fibronectin modulates metanephric kidney development.
bioRxiv 2022.07.01.497442; doi: doi.org/10.1101/2022.07.01.497442
Link

Hermann K, Seibold S, Skoczynski K, Buchholz B, Tamm ER, Herrnberger-Eimer L.
Fibronectin deficiency in newborn mice leads to cyst formation in the kidney.
bioRxiv 2022.07.18.500556; doi: doi.org/10.1101/2022.07.18.500556
Link

Hegner P, Drzymalski M, Biedermann A, Memmel B, Durczok M, Wester M, Floerchinger B, Provaznik Z, Schmid C, Zausig Y, Maier LS, Wagner S.
SAR296968, a Novel Selective Na+/Ca2+ Exchanger Inhibitor, Improves Ca2+ Handling and Contractile Function in Human Atrial Cardiomyocytes.
Biomedicines. 2022 Aug 9;10(8):1932. doi: 10.3390/biomedicines10081932. PMID: 36009478; PMCID: PMC9406204.
PubMed

Lebek S, Hegner P, Hultsch R, Rohde J, Rupprecht L, Schmid C, Sossalla S, Maier LS, Arzt M, Wagner S.
Na_v1.8 Dysregulates Na and Ca Leading to Arrhythmias in Patients with Sleep-disordered Breathing.
Am J Respir Crit Care Med. 2022 Aug 9. doi: 10.1164/rccm.202205-0981LE. Epub ahead of print. PMID: 35944144.
PubMed

Olinger E, Schaeffer C, Kidd K, Elhassan EAE, Cheng Y, Dufour I, Schiano G, Mabillard H, Pasqualetto E, Hofmann P, Fuster DG, Kistler AD, Wilson IJ, Kmoch S, Raymond L, Robert T; Genomics England Research Consortium, Eckardt KU, Bleyer AJ Sr, Köttgen A, Conlon PJ, Wiesener M, Sayer JA, Rampoldi L, Devuyst O.
An intermediate-effect size variant in UMOD confers risk for chronic kidney disease.
Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2114734119. doi: 10.1073/pnas.2114734119. Epub 2022 Aug 10. PMID: 35947615; PMCID: PMC9388113.
PubMed

Pearce D, Manis AD, Nesterov V, Korbmacher C.
Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology.
Pflugers Arch. 2022 Aug;474(8):869-884. doi: 10.1007/s00424-022-02732-5. Epub 2022 Jul 27. PMID: 35895103; PMCID: PMC9338908.
PubMed

Gorski M, Rasheed H, Teumer A, Thomas LF, Graham SE, Sveinbjornsson G, Winkler TW, Günther F, Stark KJ, Chai JF, Tayo BO, Wuttke M, Li Y, Tin A, Ahluwalia TS, Ärnlöv J, Åsvold BO, Bakker SJL, Banas B, Bansal N, Biggs ML, Biino G, Böhnke M, Boerwinkle E, Bottinger EP, Brenner H, Brumpton B, Carroll RJ, Chaker L, Chalmers J, Chee ML, Chee ML, Cheng CY, Chu AY, Ciullo M, Cocca M, Cook JP, Coresh J, Cusi D, de Borst MH, Degenhardt F, Eckardt KU, Endlich K, Evans MK, Feitosa MF, Franke A, Freitag-Wolf S, Fuchsberger C, Gampawar P, Gansevoort RT, Ghanbari M, Ghasemi S, Giedraitis V, Gieger C, Gudbjartsson DF, Hallan S, Hamet P, Hishida A, Ho K, Hofer E, Holleczek B, Holm H, Hoppmann A, Horn K, Hutri-Kähönen N, Hveem K, Hwang SJ, Ikram MA, Josyula NS, Jung B, Kähönen M, Karabegović I, Khor CC, Koenig W, Kramer H, Krämer BK, Kühnel B, Kuusisto J, Laakso M, Lange LA, Lehtimäki T, Li M, Lieb W; Lifelines Cohort Study, Lind L, Lindgren CM, Loos RJF, Lukas MA, Lyytikäinen LP, Mahajan A, Matias-Garcia PR, Meisinger C, Meitinger T, Melander O, Milaneschi Y, Mishra PP, Mononen N, Morris AP, Mychaleckyj JC, Nadkarni GN, Naito M, Nakatochi M, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Nutile T, O'Donoghue ML, O'Connell J, Olafsson I, Orho-Melander M, Parsa A, Pendergrass SA, Penninx BWJH, Pirastu M, Preuss MH, Psaty BM, Raffield LM, Raitakari OT, Rheinberger M, Rice KM, Rizzi F, Rosenkranz AR, Rossing P, Rotter JI, Ruggiero D, Ryan KA, Sabanayagam C, Salvi E, Schmidt H, Schmidt R, Scholz M, Schöttker B, Schulz CA, Sedaghat S, Shaffer CM, Sieber KB, Sim X, Sims M, Snieder H, Stanzick KJ, Thorsteinsdottir U, Stocker H, Strauch K, Stringham HM, Sulem P, Szymczak S, Taylor KD, Thio CHL, Tremblay J, Vaccargiu S, van der Harst P, van der Most PJ, Verweij N, Völker U, Wakai K, Waldenberger M, Wallentin L, Wallner S, Wang J, Waterworth DM, White HD, Willer CJ, Wong TY, Woodward M, Yang Q, Yerges-Armstrong LM, Zimmermann M, Zonderman AB, Bergler T, Stefansson K, Böger CA, Pattaro C, Köttgen A, Kronenberg F, Heid IM.
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.
Kidney Int. 2022 Sep;102(3):624-639. doi: 10.1016/j.kint.2022.05.021. Epub 2022 Jun 16. PMID: 35716955.
PubMed

Popp B, Ekici AB, Knaup KX, Schneider K, Uebe S, Park J, Bafna V, Meiselbach H, Eckardt KU, Schiffer M, Reis A, Kraus C, Wiesener M.
Prevalence of hereditary tubulointerstitial kidney diseases in the German Chronic Kidney Disease study.
Eur J Hum Genet. 2022 Sep 13. doi: 10.1038/s41431-022-01177-9. Epub ahead of print. PMID: 36100708.
PubMed

Schreiber R, Cabrita I, Kunzelmann K.
Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f.
Gastro Hep Advances 2022; Vol 1, Issue 6:1088-1098, ISSN 2772-5723, doi.org/10.1016/j.gastha.2022.08.002
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Fuchs MAA, Schrankl J, Wagner C, Daniel C, Kurtz A, Broeker KA.
Localization and characterization of Proenkephalin-A as a potential biomarker for kidney disease in murine and human kidneys.
Biomarkers. 2022 Nov 10:1-15. doi: 10.1080/1354750X.2022.2146196. Epub ahead of print. PMID: 36354355.
PubMed

Daniel C, Enghard P, Ratnatunga N, Wijetunge S, Wazil AWM, Zwiener C, Barth JAC, Chandrajith R, Klewer M, Eckhardt KU, Amann K, Freund P, Premarathne S, Pushpakumara WDRN, Nanayakkara N.
Early Ultrastructural Changes in Biopsies From Patients With Symptomatic CKD of Uncertain Etiology.
Kidney Int Rep. 2022 Dec 31;8(3):642-657. doi: 10.1016/j.ekir.2022.12.022. PMID: 36938087; PMCID: PMC10014386.
Pubmed

2021

2021

Cabrita I, Benedetto R, Wanitchakool P, Lerias J, Centeio R, Ousingsawat J, Schreiber R, Kunzelmann K.
TMEM16A Mediates Mucus Production in Human Airway Epithelial Cells.
Am J Respir Cell Mol Biol. 2021 Jan;64(1):50-58. doi: 10.1165/rcmb.2019-0442OC. PMID: 33026825.
Pubmed

Benz K, Ferrazzi F, Galiano M, Sauerstein K, Vonbrunn E, Daniel C, Büttner-Herold M, Amann K.
Relevance of glomerular C4d deposition in pediatric patients with Henoch-Schönlein Purpura compared to IgA nephritis.
J Nephropathol. 2021;10(2):e16.DOI: 10.34172/jnp.2021.16.
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Pfister F, Vonbrunn E, Ries T, Jäck HM, Überla K, Lochnit G, Sheriff A, Herrmann M, Büttner-Herold M, Amann K, Daniel C.
Complement Activation in Kidneys of Patients With COVID-19.
Front Immunol. 2021 Jan 29;11:594849. doi: 10.3389/fimmu.2020.594849. PMID: 33584662; PMCID: PMC7878379.
PubMed

Amann K, Boor P, Wiech T, Singh J, Vonbrunn E, Knöll A, Hermann M, Büttner-Herold M, Daniel C, Hartmann A.
COVID-19-Auswirkungen auf die Niere [COVID-19 effects on the kidney].
Pathologe. 2021 Feb 1:1–5. German. doi: 10.1007/s00292-020-00899-1. Epub ahead of print. PMID: 33527157; PMCID: PMC7849614.
PubMed

Tafelmeier M, Luft L, Zistler E, Floerchinger B, Camboni D, Creutzenberg M, Zeman F, Schmid C, Maier LS, Wagner S, Arzt M.
Central Sleep Apnea Predicts Pulmonary Complications After Cardiac Surgery.
Chest. 2021 Feb;159(2):798-809. doi: 10.1016/j.chest.2020.07.080. Epub 2020 Aug 13. PMID: 32798522.
PubMed

Schmid F, Grigo C, Büttner-Herold M, von Hörsten S, Amann K, Daniel C.
CD161a-positive natural killer (NK) cells and α-smooth muscle actin-positive myofibroblasts were upregulated by extrarenal DPP4 in a rat model of acute renal rejection.
Diabetes Res Clin Pract. 2021 Feb 4:108691. doi: 10.1016/j.diabres.2021.108691. Epub ahead of print. PMID: 33549675.
PubMed

Ilyaskin AV, Korbmacher C, Diakov A.
Inhibition of the epithelial sodium channel (ENaC) by connexin 30 involves stimulation of clathrin-mediated endocytosis.
J Biol Chem. 2021 Feb 9:100404. doi: 10.1016/j.jbc.2021.100404. Epub ahead of print. PMID: 33577799.
PubMed

Schrankl J, Fuchs M, Broeker K, Daniel C, Kurtz A, Wagner C.
Localization of Angiotensin II Type 1 receptor gene expression in rodent and human kidneys.
Am J Physiol Renal Physiol. 2021 Feb 22. doi: 10.1152/ajprenal.00550.2020. Epub ahead of print. PMID: 33615887.
PubMed

Essigke D, Ilyaskin AV, Wörn M, Bohnert BN, Xiao M, Daniel C, Amann K, Birkenfeld AL, Szabo R, Bugge TH, Korbmacher C, Artunc F.
Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice.
Acta Physiol (Oxf). 2021 Mar 1:e13640. doi: 10.1111/apha.13640. Epub ahead of print. PMID: 33650216.
PubMed

Fuchs MAA, Broeker KAE, Schrankl J, Burzlaff N, Willam C, Wagner C, Kurtz A.
Inhibition of transforming growth factor β1 signaling in resident interstitial cells attenuates profibrotic gene expression and preserves erythropoietin production during experimental kidney fibrosis in mice.
Kidney Int. 2021 Mar 8:S0085-2538(21)00278-7. doi: 10.1016/j.kint.2021.02.035. Epub ahead of print. PMID: 33705825.
PubMed

Park JH, Ousingsawat J, Cabrita I, Bettels RE, Große-Onnebrink J, Schmalstieg C, Biskup S, Reunert J, Rust S, Schreiber R, Kunzelmann K, Marquardt T.
TMEM16A deficiency: a potentially fatal neonatal disease resulting from impaired chloride currents.
J Med Genet. 2021 Apr;58(4):247-253. doi: 10.1136/jmedgenet-2020-106978. Epub 2020 Jun 2. PMID: 32487539.
PubMed

Vonbrunn E, Serikova S, Daniel C, Amann K, Schödel J, Buchholz B, Ferrazzi F, Heller K, Apel H, Büttner-Herold M.
Significance of Glomerular Immune Reactivity in Time Zero Biopsies for Allograft Survival Beyond IgA.
Front Med (Lausanne). 2021 Apr 6;8:656840. doi: 10.3389/fmed.2021.656840. PMID: 33889588; PMCID: PMC8057301.
PubMed

Ziegler V, Fremter K, Helmchen J, Witzgall R, Castrop H.
Mesangial cells regulate the single nephron GFR and preserve the integrity of the glomerular filtration barrier: An intravital multiphoton microscopy study.
Acta Physiol (Oxf). 2021 Apr;231(4):e13592. doi: 10.1111/apha.13592. Epub 2021 Mar 11. PMID: 33269519.
PubMed

Mustroph J, Sag CM, Bähr F, Schmidtmann AL, Gupta SN, Dietz A, Islam MMT, Lücht C, Beuthner BE, Pabel S, Baier MJ, El-Armouche A, Sossalla S, Anderson ME, Möllmann J, Lehrke M, Marx N, Mohler PJ, Bers DM, Unsöld B, He T, Dewenter M, Backs J, Maier LS, Wagner S.
Loss of CASK Accelerates Heart Failure Development.
Circ Res. 2021 Apr 16;128(8):1139-1155. doi: 10.1161/CIRCRESAHA.120.318170. Epub 2021 Feb 17. PMID: 33593074; PMCID: PMC8049978.
PubMed

Cabrita I, Talbi K, Kunzelmann K, Schreiber R.
Loss of PKD1 and PKD2 share common effects on intracellular Ca2+ signaling.
Cell Calcium. 2021 Apr 24;97:102413. doi: 10.1016/j.ceca.2021.102413. Epub ahead of print. PMID: 33915319.
PubMed

Geisberger S, Bartolomaeus H, Neubert P, Willebrand R, Zasada C, Bartolomaeus T, McParland V, Swinnen D, Geuzens A, Maifeld A, Krampert L, Vogl M, Mähler A, Wilck N, Marko L, Tilic E, Forslund SK, Binger KJ, Stegbauer J, Dechend R, Kleinewietfeld M, Jantsch J, Kempa S, Müller DN.
Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes.
Circulation. 2021 Apr 28. doi: 10.1161/CIRCULATIONAHA.120.052788. Epub ahead of print. PMID: 33906377.
PubMed

Centeio R, Ousingsawat J, Schreiber R, Kunzelmann K.
CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A.
Int J Mol Sci. 2021 May 12;22(10):5133. doi: 10.3390/ijms22105133. PMID: 34066250; PMCID: PMC8151571.
PubMed

Lebek S, Hegner P, Tafelmeier M, Rupprecht L, Schmid C, Maier LS, Arzt M, Wagner S.
Female Patients With Sleep-Disordered Breathing Display More Frequently Heart Failure With Preserved Ejection Fraction.
Front Med (Lausanne). 2021 May 28;8:675987. doi: 10.3389/fmed.2021.675987. PMID: 34124106; PMCID: PMC8192825.
PubMed

Steines L, Poth H, Schuster A, Amann K, Banas B, Bergler T.
Disruption of Tfh:B Cell Interactions Prevents Antibody-Mediated Rejection in a Kidney Transplant Model in Rats: Impact of Calcineurin Inhibitor Dose.
Front Immunol. 2021 May 31;12:657894. doi: 10.3389/fimmu.2021.657894. PMID: 34135891; PMCID: PMC8201497.
PubMed

Schlingmann KP, Renigunta A, Hoorn EJ, Forst AL, Renigunta V, Atanasov V, Mahendran S, Barakat TS, Gillion V, Godefroid N, Brooks AS, Lugtenberg D, Lake J, Debaix H, Rudin C, Knebelmann B, Tellier S, Rousset-Rouvière C, Viering D, deBaaij JHF, Weber S, Palygin O, Staruschenko A, Kleta R, Houillier P, Bockenhauer D, Devuyst O, Vargas-Poussou R, Warth R, Zdebik AA, Konrad M.
Defects in KCNJ16 Cause a Novel Tubulopathy with Hypokalemia, Salt Wasting, Disturbed Acid-Base Homeostasis, and Sensorineural Deafness.
J Am Soc Nephrol. 2021 Jun 1;32(6):1498-1512.
Pubmed

Jobin K, Müller DN, Jantsch J, Kurts C.
Sodium and its manifold impact on our immune system.
Trends Immunol. 2021 Jun;42(6):469-479. doi: 10.1016/j.it.2021.04.002. Epub 2021 May 4. PMID: 33962888.
PubMed

Fischer LM, Fichte LA, Büttner-Herold M, Ferrazzi F, Amann K, Benz K, Daniel C.
Complement in Renal Disease as a Potential Contributor to Arterial Hypertension.
Kidney Blood Press Res. 2021;46(3):362-376. doi: 10.1159/000515823. Epub 2021 Jun 2. PMID: 34077925.
PubMed

Talbi K, Cabrita I, Schreiber R, Kunzelmann K.
Gender-Dependent Phenotype in Polycystic Kidney Disease Is Determined by Differential Intracellular Ca2+ Signals.
Int J Mol Sci. 2021 Jun 2;22(11):6019. doi: 10.3390/ijms22116019. PMID: 34199520; PMCID: PMC8199720.
PubMed

Berg P, Svendsen SL, Sorensen MV, Schreiber R, Kunzelmann K, Leipziger J.
The molecular mechanism of CFTR- and secretin-dependent renal bicarbonate excretion.
Physiol. 2021 Jun;599(12):3003-3011. doi: 10.1113/JP281285. Epub 2021 May 29. PMID: 33963548.
PubMed

Bach C, Knaup KX, Herrmann M, Krumbiegel M, Pfister F, Büttner-Herold M, Steffen M, Zecher D, Lopau K, Schneider K, Dieterle A, Amann K, Reis A, Schiffer M, Spriewald BM, Wiesener MS.
A noninvasive diagnostic approach to retrospective donor HLA typing in kidney transplant patients using urine.
Transpl Int. 2021 Jul;34(7):1226-1238. doi: 10.1111/tri.13893. Epub 2021 Jun 16. PMID: 33904183.
PubMed

Häckl M, Tauber P, Schweda F, Zacharias HU, Altenbuchinger M, Oefner PJ, Gronwald W.
An R-Package for the Deconvolution and Integration of 1D NMR Data: MetaboDecon1D. Metabolites. 2021 Jul 13;11(7):452. doi: 10.3390/metabo11070452. PMID: 34357346; PMCID: PMC8305572.
PubMed

Stanzick KJ, Li Y, Schlosser P, Gorski M, Wuttke M, Thomas LF, Rasheed H, Rowan BX, Graham SE, Vanderweff BR, Patil SB; VA Million Veteran Program, Robinson-Cohen C, Gaziano JM, O'Donnell CJ, Willer CJ, Hallan S, Åsvold BO, Gessner A, Hung AM, Pattaro C, Köttgen A, Stark KJ, Heid IM, Winkler TW.
Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals.
Nat Commun. 2021 Jul 16;12(1):4350. doi: 10.1038/s41467-021-24491-0. PMID: 34272381; PMCID: PMC8285412.
PubMed

Forst AL, Reichold M, Kleta R, Warth R.
Distinct Mitochondrial Pathologies Caused by Mutations of the Proximal Tubular Enzymes EHHADH and GATM.
Front Physiol. 2021 Jul 19;12:715485.
Pubmed

Tonnus W, Meyer C, Steinebach C, Belavgeni A, von Mässenhausen A, Gonzalez NZ, Maremonti F, Gembardt F, Himmerkus N, Latk M, Locke S, Marschner J, Li W, Short S, Doll S, Ingold I, Proneth B, Daniel C, Kabgani N, Kramann R, Motika S, Hergenrother PJ, Bornstein SR, Hugo C, Becker JU, Amann K, Anders HJ, Kreisel D, Pratt D, Gütschow M, Conrad M, Linkermann A.
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.
Nat Commun. 2021 Jul 20;12(1):4402. doi: 10.1038/s41467-021-24712-6. PMID: 34285231; PMCID: PMC8292346.
PubMed

Zacharias HU, Altenbuchinger M, Schultheiss UT, Raffler J, Kotsis F, Ghasemi S, Ali I, Kollerits B, Metzger M, Steinbrenner I, Sekula P, Massy ZA, Combe C, Kalra PA, Kronenberg F, Stengel B, Eckardt KU, Köttgen A, Schmid M, Gronwald W, Oefner PJ; GCKD Investigators.
A Predictive Model for Progression of CKD to Kidney Failure Based on Routine Laboratory Tests.
Am J Kidney Dis. 2021 Jul 20:S0272-6386(21)00729-0. doi: 10.1053/j.ajkd.2021.05.018. Epub ahead of print. PMID: 34298143.
Pubmed

Trum M, Riechel J, Wagner S.
Cardioprotection by SGLT2 Inhibitors-Does It All Come Down to Na+?
Int J Mol Sci. 2021 Jul 26;22(15):7976. doi: 10.3390/ijms22157976. PMID: 34360742; PMCID: PMC8347698.
PubMed

Vonbrunn E, Ries T, Söllner S, Müller-Deile J, Büttner-Herold M, Amann K, Daniel C.
Multiplex gene analysis reveals T-cell and antibody-mediated rejection-specific upregulation of complement in renal transplants.
Sci Rep. 2021 Jul 29;11(1):15464. doi: 10.1038/s41598-021-94954-3. PMID: 34326417; PMCID: PMC8322413.
PubMed

Schuster AM, Miesgang N, Steines L, Bach C, Banas B, Bergler T.
B-cell activating factor BAFF as a novel alert marker for the immunological risk stratification after kidney transplantation.
Immunol Res. 2021 Aug 10. doi: 10.1007/s12026-021-09205-4. Epub ahead of print. PMID: 34373996.
PubMed

Grosch M, Brunner K, Ilyaskin AV, Schober M, Staudner T, Schmied D, Stumpp T, Schmidt KN, Madej MG, Pessoa TD, Othmen H, Kubitza M, Osten L, de Vries U, Mair MM, Somlo S, Moser M, Kunzelmann K, Ziegler C, Haerteis S, Korbmacher C, Witzgall R.
A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts.
J Cell Sci. 2021 Aug 15;134(16):jcs259013. doi: 10.1242/jcs.259013. Epub 2021 Aug 23. PMID: 34345895; PMCID: PMC8435292.
PubMed

Talbi K, Ousingsawat J, Centeio R, Schreiber R, Kunzelmann K.
Calmodulin-Dependent Regulation of Overexpressed but Not Endogenous TMEM16A Expressed in Airway Epithelial Cells.
Membranes (Basel). 2021 Sep 21;11(9):723. doi: 10.3390/membranes11090723. PMID: 34564540; PMCID: PMC8471323.
PubMed

Neder TH, Schrankl J, Fuchs MAA, Broeker KAE, Wagner C.
Endothelin receptors in renal interstitial cells do not contribute to the development of fibrosis during experimental kidney disease.
Pflugers Arch. 2021 Oct;473(10):1667-1683. doi: 10.1007/s00424-021-02604-4. Epub 2021 Aug 6. PMID: 34355294 ; PMCID: PMC8433107.
PubMed

Islam MMT, Tarnowski D, Zhang M, Trum M, Lebek S, Mustroph J, Daniel H, Moellencamp J, Pabel S, Sossalla S, El-Armouche A, Nikolaev VO, Shah AM, Eaton P, Maier LS, Sag CM, Wagner S.
Enhanced Heart Failure in Redox-Dead Cys17Ser PKARIα Knock-In Mice.
J Am Heart Assoc. 2021 Oct 5;10(19):e021985. doi: 10.1161/JAHA.121.021985. Epub 2021 Sep 29. PMID: 34583520; PMCID: PMC8649132.
PubMed

Lebek S, Wester M, Pec J, Poschenrieder F, Tafelmeier M, Fisser C, Provaznik Z, Schopka S, Debl K, Schmid C, Buchner S, Maier LS, Arzt M, Wagner S.
Abnormal P-wave terminal force in lead V1 is a marker for atrial electrical dysfunction but not structural remodelling.
ESC Heart Fail. 2021 Oct;8(5):4055-4066. doi: 10.1002/ehf2.13488. Epub 2021 Jun 30. PMID: 34196135; PMCID: PMC8497361.
PubMed

Hegner P, Lebek S, Maier LS, Arzt M, Wagner S.
The Effect of Gender and Sex Hormones on Cardiovascular Disease, Heart Failure, Diabetes, and Atrial Fibrillation in Sleep Apnea.
Front Physiol. 2021 Oct 20;12:741896. doi: 10.3389/fphys.2021.741896. PMID: 34744785; PMCID: PMC8564381.
PubMed

Ousingsawat J, Schreiber R, Gulbins E, Kamler M, Kunzelmann K.
P. aeruginosa Induced Lipid Peroxidation Causes Ferroptotic Cell Death in Airways.
Cell Physiol Biochem. 2021 Oct 13;55(5):590-604. doi: 10.33594/000000437. PMID: 34637202.
PubMed

Talbi K, Cabrita I, Kraus A, Hofmann S, Skoczynski K, Kunzelmann K, Buchholz B, Schreiber R.
The chloride channel CFTR is not required for cyst growth in an ADPKD mouse model.
FASEB J. 2021 Oct;35(10):e21897. doi: 10.1096/fj.202100843R. PMID: 34473378.
PubMed

Mustroph J, Hupf J, Baier MJ, Evert K, Brochhausen C, Broeker K, Meindl C, Seither B, Jungbauer C, Evert M, Maier LS, Wagner S.
Cardiac Fibrosis Is a Risk Factor for Severe COVID-19.
Front Immunol. 2021 Oct 22;12:740260. doi: 10.3389/fimmu.2021.740260. PMID: 34745111; PMCID: PMC8569622.
PubMed

Buerger K, Schmidt KN, Fokkema J, Gerritsen HC, Maier O, de Vries U, Zaytseva Y, Rachel R, Witzgall R.
On-section correlative light and electron microscopy of large cellular volumes using STEM tomography.
Methods Cell Biol. 2021;162:171-203. doi: 10.1016/bs.mcb.2020.09.002. Epub 2020 Oct 31. PMID: 33707012.
PubMed

Schwarz H, Popp B, Airik R, Torabi N, Knaup KX, Stoeckert J, Wiech T, Amann K, Reis A, Schiffer M, Wiesener MS, Schueler M.
Biallelic ANKS6 mutations cause late onset ciliopathy with chronic kidney disease through YAP dysregulation.
Hum Mol Genet. 2021 Nov 5:ddab322. doi: 10.1093/hmg/ddab322. Epub ahead of print. PMID: 34740236.
PubMed

Mustroph J, Hupf J, Hanses F, Evert K, Baier MJ, Evert M, Meindl C, Wagner S, Hubauer U, Pietrzyk G, Leininger S, Staudner S, Vogel M, Wallner S, Zimmermann M, Sossalla S, Maier LS, Jungbauer C.
Decreased GLUT1/NHE1 RNA expression in whole blood predicts disease severity in patients with COVID-19.
ESC Heart Fail. 2021 Feb;8(1):309-316. doi: 10.1002/ehf2.13063. Epub 2020 Nov 20. PMID: 33215884; PMCID: PMC7835506.
PubMed

Pec J, Wester M, Fisser C, Debl K, Hamer OW, Poschenrieder F, Buchner S, Maier LS, Arzt M, Wagner S.
Central Sleep Apnea Is Associated with an Abnormal P-Wave Terminal Force in Lead V1 in Patients with Acute Myocardial Infarction Independent from Ventricular Function.
J Clin Med. 2021 Nov 26;10(23):5555. doi: 10.3390/jcm10235555. PMID: 34884253; PMCID: PMC8658572.
PubMed

Broeker KAE, Fuchs MAA, Schrankl J, Lehrmann C, Schley G, Todorov VT, Hugo C, Wagner C, Kurtz A.
Prolyl-4-hydroxylases 2 and 3 control erythropoietin production in renin expressing cells of mouse kidneys.
J Physiol. 2021 Dec 4. doi: 10.1113/JP282615. Epub ahead of print. PMID: 34863041.
PubMed

Artunc F, Bohnert BN, Schneider JC, Staudner T, Sure F, Ilyaskin AV, Wörn M, Essigke D, Janessa A, Nielsen NV, Birkenfeld AL, Etscheid M, Haerteis S, Korbmacher C, Kanse SM.
Proteolytic activation of the epithelial sodium channel (ENaC) by factor VII activating protease (FSAP) and its relevance for sodium retention in nephrotic mice.
Pflugers Arch. 2021 Dec 6. doi: 10.1007/s00424-021-02639-7. Epub ahead of print. PMID: 34870751.
PubMed

Hegner P, Lebek S, Tafelmeier M, Camboni D, Schopka S, Schmid C, Maier LS, Arzt M, Wagner S.
Sleep-disordered breathing is independently associated with reduced atrial connexin 43 expression.
Heart Rhythm. 2021 Dec;18(12):2187-2194. doi: 10.1016/j.hrthm.2021.09.009. Epub 2021 Sep 10. PMID: 34517118.
PubMed

Tauber P, Sinha F, Berger RS, Gronwald W, Dettmer K, Kuhn M, Trum M, Maier LS, Wagner S, Schweda F.
Empagliflozin Reduces Renal Hyperfiltration in Response to Uninephrectomy, but Is Not Nephroprotective in UNx/DOCA/Salt Mouse Models.
Front Pharmacol. 2021 Dec 21;12:761855. doi: 10.3389/fphar.2021.761855. PMID: 34992532; PMCID: PMC8724563.
Pubmed

Steines L, Scharf M, Hoffmann P, Schuster A, Banas B, Bergler T.
Monitoring B cell alloresponses in rats. J Immunol Methods.
2021 Dec 29;501:113212. doi: 10.1016/j.jim.2021.113212. Epub ahead of print. PMID: 34971633.
PubMed

2020

Steines L, Poth H, Schuster A, Geissler EK, Amann K, Banas B, Bergler T. Anti-BAFF Treatment Interferes With Humoral Responses in a Model of Renal Transplantation in Rats.
Transplantation. 2020 Jan;104 (1):e16-e22. doi: 10.1097/TP.0000000000002992.
Pubmed

Morin M, Forst AL, Pérez-Torre P, Jiménez-Escrig A, Barca-Tierno V, García-Galloway E, Warth R, Lopez-Sendón Moreno JL, Moreno-Pelayo MA
Novel mutations in the KCNJ10 gene associated to a distinctive ataxia, sensorineural hearing loss and spasticity clinical phenotype.
Neurogenetics. 2020 Feb 15. doi: 10.1007/s10048-020-00605-6.
Pubmed

Lebek S, Pichler K, Reuthner K, Trum M, Tafelmeier M, Mustroph J, Camboni D, Rupprecht L, Schmid C, Maier LS, Arzt M, Wagner S.
Enhanced CaMKII-Dependent Late I_Na Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing.
Circ Res. 2020 Feb 28;126(5):603-615. doi: 10.1161/CIRCRESAHA.119.315755. Epub 2020 Jan 6. Erratum in: Circ Res. 2020 Apr 10;126(8):e60. PMID: 31902278.
PubMed

Rauh R, Frost F, Korbmacher C.
Effects of syntaxins 2, 3, and 4 on rat and human epithelial sodium channel (ENaC) in Xenopus laevis oocytes.
Pflugers Arch. 2020 Apr;472(4):461-471. doi: 10.1007/s00424-020-02365-6. Epub 2020 Mar 27. PMID: 32221667; PMCID: PMC7165155.
PubMed

Maslanka Figueroa S, Fleischmann D, Beck S, Tauber P, Witzgall R, Schweda F, Goepferich A.
Nanoparticles Mimicking Viral Cell Recognition Strategies Are Superior Transporters into Mesangial Cells.
Adv Sci (Weinh). 2020 Apr 22;7(11):1903204. doi: 10.1002/advs.201903204. PMID: 32537398; PMCID: PMC7284201.
PubMed

Frindt G, Bertog M, Korbmacher C, Palmer LG.
Ubiquitination of renal ENaC subunits in vivo.
Am J Physiol Renal Physiol. 2020 May 1;318(5):F1113-F1121. doi: 10.1152/ajprenal.00609.2019. Epub 2020 Mar 16. PMID: 32174140; PMCID: PMC7294337.
PubMed

Pinto MC, Schreiber R, Lerias J, Ousingsawat J, Duarte A, Amaral M, Kunzelmann K.
Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation.
Cells. 2020 May 5;9(5):1138. doi: 10.3390/cells9051138. PMID: 32380794; PMCID: PMC7291285.
PubMed

Broeker KAE, Fuchs MAA, Schrankl J, Kurt B, Nolan KA, Wenger RH, Kramann R, Wagner C, Kurtz A.
Different Subpopulations of Kidney Interstitial Cells Produce Erythropoietin and Factors Supporting Tissue Oxygenation in Response to Hypoxia in Vivo.
Kidney Int. 2020 May 23;S0085-2538(20)30542-1.doi: 10.1016/j.kint.2020.04.040.
PubMed

Buchholz B, Eckardt KU.
Role of oxygen and the HIF-pathway in polycystic kidney disease.
Cell Signal. 2020 May;69:109524. doi: 10.1016/j.cellsig.2020.109524. Epub 2020 Jan 2. PMID: 31904413.
PubMed

Cabrita I, Buchholz B, Schreiber R, Kunzelmann K.
TMEM16A Drives Renal Cyst Growth by Augmenting Ca 2+ Signaling in M1 Cells.
J Mol Med (Berl). 2020 May;98(5):659-671. doi: 10.1007/s00109-020-01894-y. Epub 2020 Mar 18.
PubMed

Amann K, Daniel C, Büttner-Herold M.
Das Komplementsystem – ein „hot topic“ nicht nur bei Nierenerkrankungen [The complement system-a "hot topic" not only for kidney diseases].
Pathologe. 2020 May;41(3):238-247. German. doi: 10.1007/s00292-020-00773-0. PMID: 32240352.
PubMed

Wiesener A, Knaup KX, Büttner-Herold M, Dieterle A, Stoeckert J, Riedl B, Morath C, Wald A, Vondran F, Braun F, Schödel J, Schueler M, Schiffer M, Amann K, Reis A, Kraus C, Wiesener MS.
Molecular diagnosis of kidney transplant failure based on urine.
Am J Transplant. 2020 May;20(5):1410-1416. doi: 10.1111/ajt.15738. Epub 2020 Jan 20.
Pubmed

Trum M, Wagner S, Maier LS, Mustroph J.
CaMKII and GLUT1 in heart failure and the role of gliflozins.
Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165729. doi: 10.1016/j.bbadis.2020.165729. Epub 2020 Feb 14. PMID: 32068116.
PubMed

Schreiber R, Ousingsawat J, Kunzelmann K.
Targeting of Intracellular TMEM16 Proteins to the Plasma Membrane and Activation by Purinergic Signaling.
Int J Mol Sci. 2020 Jun 5;21(11):4065. doi: 10.3390/ijms21114065. PMID: 32517157; PMCID: PMC7312528.
PubMed

Neubert P, Homann A, Wendelborn D, Bär AL, Krampert L, Trum M, Schröder A, Ebner S, Weichselbaum A, Schatz V, Linz P, Veelken R, Schulte-Schrepping J, Aschenbrenner AC, Quast T, Kurts C, Geisberger S, Kunzelmann K, Hammer K, Binger KJ, Titze J, Müller DN, Kolanus W, Schultze JL, Wagner S, Jantsch J.
NCX1 represents an ionic Na+ sensing mechanism in macrophages.
PLoS Biol. 2020 Jun 22;18(6):e3000722. doi: 10.1371/journal.pbio.3000722.
Pubmed

Penton D, Vohra T, Banki E, Wengi A, Weigert M, Forst AL, Bandulik S, Warth R, Loffing J.
Collecting system-specific deletion of Kcnj10 predisposes for thiazide- and low-potassium diet-induced hypokalemia.
Kidney Int. 2020 Jun;97(6):1208-1218.
Pubmed

Hofhuis J, Bersch K, Wagner S, Molina C, Fakuade FE, Iyer LM, Streckfuss-Bömeke K, Toischer K, Zelarayán LC, Voigt N, Nikolaev VO, Maier LS, Klinge L, Thoms S. Dysferlin links excitation-contraction coupling to structure and maintenance of the cardiac transverse-axial tubule system.
Europace. 2020 Jul 1;22(7):1119-1131. doi: 10.1093/europace/euaa093. PMID: 32572487.
PubMed

Schach C, Wester M, Leibl F, Redel A, Gruber M, Maier LS, Endemann D, Wagner S.
Reduced store-operated Ca²⁺ entry impairs mesenteric artery function in response to high external glucose in type 2 diabetic ZDF rats.
Clin Exp Pharmacol Physiol. 2020 Jul;47(7):1145-1157. doi: 10.1111/1440-1681.13300. Epub 2020 Mar 30. PMID: 32147830.
PubMed

Bengel P, Ahmad S, Tirilomis P, Trum M, Dybkova N, Wagner S, Maier LS, Hasenfuß G, Sossalla S.
Contribution of the neuronal sodium channel Na_V1.8 to sodium- and calcium-dependent cellular proarrhythmia.
J Mol Cell Cardiol. 2020 Jul;144:35-46. doi: 10.1016/j.yjmcc.2020.05.002. Epub 2020 May 11. PMID: 32418916.
PubMed

Mansley MK, Niklas C, Nacken R, Mandery K, Glaeser H, Fromm MF, Korbmacher C, Bertog M.
Prostaglandin E2 stimulates the epithelial sodium channel (ENaC) in cultured mouse cortical collecting duct cells in an autocrine manner.
J Gen Physiol. 2020 Aug 3;152(8):e201912525. doi: 10.1085/jgp.201912525. PMID: 32442241; PMCID: PMC7398144.
PubMed

Fleischmann D, Maslanka Figueroa S, Beck S, Abstiens K, Witzgall R, Schweda F, Tauber P, Goepferich A.
Adenovirus-Mimetic Nanoparticles: Sequential Ligand-Receptor Interplay as a Universal Tool for Enhanced In Vitro/In Vivo Cell Identification.
ACS Appl Mater Interfaces. 2020 Aug 5;12(31):34689-34702. doi: 10.1021/acsami.0c10057. Epub 2020 Jul 22. PMID: 32639709.
PubMed

Cabrita I, Kraus A, Scholz JK, Skoczynski K, Schreiber R, Kunzelmann K, Buchholz B.
Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo.
Nat Commun. 2020 Aug 28;11(1):4320. doi: 10.1038/s41467-020-18104-5.
Pubmed

Leppkes M, Knopf J, Naschberger E, Lindemann A, Singh J, Herrmann I, Stürzl M, Staats L, Mahajan A, Schauer C, Kremer AN, Völkl S, Amann K, Evert K, Falkeis C, Wehrfritz A, Rieker RJ, Hartmann A, Kremer AE, Neurath MF, Muñoz LE, Schett G, Herrmann M.
Vascular occlusion by neutrophil extracellular traps in COVID-19.
EBioMedicine. 2020 Aug;58:102925. doi: 10.1016/j.ebiom.2020.102925. Epub 2020 Jul 31. PMID: 32745993; PMCID: PMC7397705.
PubMed

Berg P, Svendsen S L, Sorensen M V, Larsen C K, Andersen J F, Jensen-Fangel S, Jeppesen M, Schreiber R, Cabrita I, Kunzelmann K, Leipziger J.
Impaired Renal HCO3- Excretion in Cystic Fibrosis.
J Am Soc Nephrol. J Am Soc Nephrol. 2020 Aug;31(8):1711-1727.
Pubmed

Rachel R, Walther P, Maaßen C, Daberkow I, Matsuoka M, Witzgall R.
Dual-axis STEM tomography at 200 kV: Setup, performance, limitations.
J Struct Biol. 2020 Sep 1;211(3):107551. doi: 10.1016/j.jsb.2020.107551. Epub 2020 Jun 24. PMID: 32589927.
Pubmed

Safi W, Kraus A, Grampp S, Schödel J, Buchholz B.
Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner.
J Mol Med (Berl). 2020 Sep 4. doi: 10.1007/s00109-020-01964-1.
Pubmed

Trum M, Riechel J, Lebek S, Pabel S, Sossalla ST, Hirt S, Arzt M, Maier LS, Wagner S.
Empagliflozin inhibits Na⁺ /H⁺ exchanger activity in human atrial cardiomyocytes.
ESC Heart Fail. 2020 Sep 18;7(6):4429–37. doi: 10.1002/ehf2.13024. Epub ahead of print. PMID: 32946200; PMCID: PMC7755005.
PubMed

Mustroph J, Drzymalski M, Baier M, Pabel S, Biedermann A, Memmel B, Durczok M, Neef S, Sag CM, Floerchinger B, Rupprecht L, Schmid C, Zausig Y, Bégis G, Briand V, Ozoux ML, Tamarelle D, Ballet V, Janiak P, Beauverger P, Maier LS, Wagner S.
The oral Ca/calmodulin-dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure.
ESC Heart Fail. 2020 Oct;7(5):2871-2883. doi: 10.1002/ehf2.12895. Epub 2020 Jul 20. PMID: 32691522; PMCID: PMC7524064.
PubMed

Li W, Stauske M, Luo X, Wagner S, Vollrath M, Mehnert CS, Schubert M, Cyganek L, Chen S, Hasheminasab SM, Wulf G, El-Armouche A, Maier LS, Hasenfuss G, Guan K.
Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation.
Front Cell Dev Biol. 2020 Oct 22;8:592893. doi: 10.3389/fcell.2020.592893. PMID: 33195263; PMCID: PMC7642519.
PubMed

Steines L, Poth H, Herrmann M, Schuster A, Banas B, Bergler T.
B Cell Activating Factor (BAFF) is Required for the Development of Intra-Renal Tertiary Lymphoid Organs in Experimental Kidney Transplantation in Rats.
Int J Mol Sci. 2020 Oct 28;21(21):E8045. doi: 10.3390/ijms21218045. PMID: 33126753.
Pubmed

Gorski M, Jung B, Li Y, Matias-Garcia PR, Wuttke M, Coassin S, Thio CHL, Kleber ME, Winkler TW, Wanner V, Chai JF, Chu AY, Cocca M, Feitosa MF, Ghasemi S, Hoppmann A, Horn K, Li M, Nutile T, Scholz M, Sieber KB, Teumer A, Tin A, Wang J, Tayo BO, Ahluwalia TS, Almgren P, Bakker SJL, Banas B, Bansal N, Biggs ML, Boerwinkle E, Bottinger EP, Brenner H, Carroll RJ, Chalmers J, Chee ML, Chee ML, Cheng CY, Coresh J, de Borst MH, Degenhardt F, Eckardt KU, Endlich K, Franke A, Freitag-Wolf S, Gampawar P, Gansevoort RT, Ghanbari M, Gieger C, Hamet P, Ho K, Hofer E, Holleczek B, Xian Foo VH, Hutri-Kähönen N, Hwang SJ, Ikram MA, Josyula NS, Kähönen M, Khor CC, Koenig W, Kramer H, Krämer BK, Kühnel B, Lange LA, Lehtimäki T, Lieb W; Lifelines cohort study; Regeneron Genetics Center, Loos RJF, Lukas MA, Lyytikäinen LP, Meisinger C, Meitinger T, Melander O, Milaneschi Y, Mishra PP, Mononen N, Mychaleckyj JC, Nadkarni GN, Nauck M, Nikus K, Ning B, Nolte IM, O'Donoghue ML, Orho-Melander M, Pendergrass SA, Penninx BWJH, Preuss MH, Psaty BM, Raffield LM, Raitakari OT, Rettig R, Rheinberger M, Rice KM, Rosenkranz AR, Rossing P, Rotter JI, Sabanayagam C, Schmidt H, Schmidt R, Schöttker B, Schulz CA, Sedaghat S, Shaffer CM, Strauch K, Szymczak S, Taylor KD, Tremblay J, Chaker L, van der Harst P, van der Most PJ, Verweij N, Völker U, Waldenberger M, Wallentin L, Waterworth DM, White HD, Wilson JG, Wong TY, Woodward M, Yang Q, Yasuda M, Yerges-Armstrong LM, Zhang Y, Snieder H, Wanner C, Böger CA, Köttgen A, Kronenberg F, Pattaro C, Heid IM.
Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline.
Kidney Int. 2020 Oct 30:S0085-2538(20)31239-4. doi: 10.1016/j.kint.2020.09.030. Epub ahead of print. PMID: 33137338.
PubMed

Weitzel A, Samol C, Oefner PJ, Gronwald W.
Robust Metabolite Quantification from J-Compensated 2D 1H-13C-HSQC Experiments.
Metabolites. 2020 Nov 7;10(11):E449. doi: 10.3390/metabo10110449. PMID: 33171777.
PubMed

Westhoff TH, Seibert FS, Bauer F, Stervbo U, Anft M, Doevelaar AAN, Rohn BJ, Winnekendonk G, Dittmer U, Schenker P, Vonbrunn E, Amann K, Viebahn R, Babel N.
Allograft infiltration and meningoencephalitis by SARS-CoV-2 in a pancreas-kidney transplant recipient.
Am J Transplant. 2020 Nov;20(11):3216-3220. doi: 10.1111/ajt.16223. Epub 2020 Aug 30. PMID: 32713123.
PubMed

Špiranec Spes K, Chen W, Krebes L, Völker K, Abeßer M, Eder Negrin P, Cellini A, Nickel A, Nikolaev VO, Hofmann F, Schuh K, Schweda F, Kuhn M.
Heart-Microcirculation Connection: Effects of ANP (Atrial Natriuretic Peptide) on Pericytes Participate in the Acute and Chronic Regulation of Arterial Blood Pressure. Hypertension. 2020 Nov;76(5):1637-1648. doi: 10.1161/HYPERTENSIONAHA.120.15772. Epub 2020 Sep 21. PMID: 32951468.
PubMed

Doevelaar AAN, Hölzer B, Seibert FS, Bauer F, Stervbo U, Rohn BJ, Zgoura P, Schenker P, Vonbrunn E, Amann K, Viebahn R, Babel N, Westhoff TH.
Lessons for the clinical nephrologist: recurrence of nephrotic syndrome induced by SARS-CoV-2.
J Nephrol. 2020 Dec;33(6):1369-1372. doi: 10.1007/s40620-020-00855-5. Epub 2020 Sep 5. PMID: 32892322; PMCID: PMC7474570.
PubMed

Trum M, Islam MMT, Lebek S, Baier M, Hegner P, Eaton P, Maier LS, Wagner S.
Inhibition of cardiac potassium currents by oxidation-activated protein kinase A contributes to early afterdepolarizations in the heart.
Am J Physiol Heart Circ Physiol. 2020 Dec 1;319(6):H1347-H1357. doi: 10.1152/ajpheart.00182.2020. Epub 2020 Oct 9. PMID: 33035439; PMCID: PMC7792712.
PubMed

Lebek S, Hegner P, Schach C, Reuthner K, Tafelmeier M, Maier LS, Arzt M, Wagner S.
A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction.
PLoS One. 2020 Dec 10;15(12):e0243844. doi: 10.1371/journal.pone.0243844. PMID: 33301470; PMCID: PMC7728202.
PubMed

Lebek S, Tafelmeier M, Messmann R, Provaznik Z, Schmid C, Maier LS, Birner C, Arzt M, Wagner S.
Angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker treatment and haemodynamic factors are associated with increased cardiac mRNA expression of angiotensin-converting enzyme 2 in patients with cardiovascular disease.
Eur J Heart Fail. 2020 Dec;22(12):2248-2257. doi: 10.1002/ejhf.2020. Epub 2020 Oct 20. PMID: 33017071; PMCID: PMC7675329.
PubMed

2019

Schreiber, R., Buchholz, B., Kraus, A., Schley, G., Scholz, J., Ousingsawat, J., Kunzelmann, K.
Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A.
J Am Soc Nephrol. 2019 Feb;30(2):228-242. doi: 10.1681/ASN.2018010039. Epub 2019 Jan 3.
PubMed

Kunzelmann K, Ousingsawat J, Benedetto R, Cabrita I, Schreiber R.
Contribution of Anoctamins to Cell Survival and Cell Death.
Cancers (Basel). 2019 Mar 19;11(3). pii: E382. doi: 10.3390/cancers11030382.
Pubmed

Zacharias HU, Altenbuchinger M, Schultheiss UT, Samol C, Kotsis F, Poguntke I, Sekula P, Krumsiek J, Köttgen A, Spang R, Oefner PJ, Gronwald W.
A Novel Metabolic Signature To Predict the Requirement of Dialysis or Renal Transplantation in Patients with Chronic Kidney Disease.
J Proteome Res. 2019 Apr 5;18(4):1796-1805. doi: 10.1021/acs.jproteome.8b00983. Epub 2019 Mar 12. PMID: 30817158.
PubMed

Mustroph J, Lücht CM, Wagemann O, Sowa T, Hammer KP, Sag CM, Tarnowski D, Holzamer A, Pabel S, Beuthner BE, Sossalla S, Maier LS, Wagner S.
Empagliflozin enhances human and murine cardiomyocyte glucose uptake by increased expression of GLUT1.
Diabetologia. 2019 Apr;62(4):726-729. doi: 10.1007/s00125-019-4819-z. PMID: 30694352.
PubMed

Schrankl J, Neubauer B, Fuchs M, Gerl K, Wagner C, Kurtz A.
Apparently normal kidney development in mice with conditional disruption of ANGII-AT1 receptor genes in FoxD1 positive stroma cell precursors
Am J Physiol Renal Physiol 2019 Apr 10 doi: 10.1152/ajprenal.00305.2018
Pubmed

Bohnert BN, Daiminger S, Wörn M, Sure F, Staudner T, Ilyaskin AV, Batbouta F, Janessa A, Schneider JC, Essigke D, Kanse S, Haerteis S, Korbmacher C, Artunc F.
Urokinase-type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)-mediated sodium retention in experimental nephrotic syndrome.
Acta Physiol (Oxf). 2019 Apr 21:e13286. doi: 10.1111/apha.13286. [Epub ahead of print]
Pubmed

Benedetto R, Ousingsawat J, Cabrita I, Pinto M, Lérias JR, Wanitchakool P, Schreiber R, Kunzelmann K.
Plasma membrane-localized TMEM16 proteins are indispensable for expression of CFTR.
J Mol Med (Berl). 2019 May;97(5):711-722. doi: 10.1007/s00109-019-01770-4. Epub 2019 Mar 26.
Pubmed

Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF, Gorski M, Tin A, Wang L, Chu AY, Hoppmann A, Kirsten H, Giri A, Chai JF, Sveinbjornsson G, Tayo BO, Nutile T, Fuchsberger C, Marten J, Cocca M, Ghasemi S, Xu Y, Horn K, Noce D, van der Most PJ, Sedaghat S, Yu Z, Akiyama M, Afaq S, Ahluwalia TS, Almgren P, Amin N, Ärnlöv J, Bakker SJL, Bansal N, Baptista D, Bergmann S, Biggs ML, Biino G, Boehnke M, Boerwinkle E, Boissel M, Bottinger EP, Boutin TS, Brenner H, Brumat M, Burkhardt R, Butterworth AS, Campana E, Campbell A, Campbell H, Canouil M, Carroll RJ, Catamo E, Chambers JC, Chee ML, Chee ML, Chen X, Cheng CY, Cheng Y, Christensen K, Cifkova R, Ciullo M, Concas MP, Cook JP, Coresh J, Corre T, Sala CF, Cusi D, Danesh J, Daw EW, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Degenhardt F, Delgado G, Demirkan A, Di Angelantonio E, Dittrich K, Divers J, Dorajoo R, Eckardt KU, Ehret G, Elliott P, Endlich K, Evans MK, Felix JF, Foo VHX, Franco OH, Franke A, Freedman BI, Freitag-Wolf S, Friedlander Y, Froguel P, Gansevoort RT, Gao H, Gasparini P, Gaziano JM, Giedraitis V, Gieger C, Girotto G, Giulianini F, Gögele M, Gordon SD, Gudbjartsson DF, Gudnason V, Haller T, Hamet P, Harris TB, Hartman CA, Hayward C, Hellwege JN, Heng CK, Hicks AA, Hofer E, Huang W, Hutri-Kähönen N, Hwang SJ, Ikram MA, Indridason OS, Ingelsson E, Ising M, Jaddoe VWV, Jakobsdottir J, Jonas JB, Joshi PK, Josyula NS, Jung B, Kähönen M, Kamatani Y, Kammerer CM, Kanai M, Kastarinen M, Kerr SM, Khor CC, Kiess W, Kleber ME, Koenig W, Kooner JS, Körner A, Kovacs P, Kraja AT, Krajcoviechova A, Kramer H, Krämer BK, Kronenberg F, Kubo M, Kühnel B, Kuokkanen M, Kuusisto J, La Bianca M, Laakso M, Lange LA, Langefeld CD, Lee JJ, Lehne B, Lehtimäki T, Lieb W; Lifelines Cohort Study, Lim SC, Lind L, Lindgren CM, Liu J, Liu J, Loeffler M, Loos RJF, Lucae S, Lukas MA, Lyytikäinen LP, Mägi R, Magnusson PKE, Mahajan A, Martin NG, Martins J, März W, Mascalzoni D, Matsuda K, Meisinger C, Meitinger T, Melander O, Metspalu A, Mikaelsdottir EK, Milaneschi Y, Miliku K, Mishra PP; V. A. Million Veteran Program, Mohlke KL, Mononen N, Montgomery GW, Mook-Kanamori DO, Mychaleckyj JC, Nadkarni GN, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Noordam R, O'Connell J, O'Donoghue ML, Olafsson I, Oldehinkel AJ, Orho-Melander M, Ouwehand WH, Padmanabhan S, Palmer ND, Palsson R, Penninx BWJH, Perls T, Perola M, Pirastu M, Pirastu N, Pistis G, Podgornaia AI, Polasek O, Ponte B, Porteous DJ, Poulain T, Pramstaller PP, Preuss MH, Prins BP, Province MA, Rabelink TJ, Raffield LM, Raitakari OT, Reilly DF, Rettig R, Rheinberger M, Rice KM, Ridker PM, Rivadeneira F, Rizzi F, Roberts DJ, Robino A, Rossing P, Rudan I, Rueedi R, Ruggiero D, Ryan KA, Saba Y, Sabanayagam C, Salomaa V, Salvi E, Saum KU, Schmidt H, Schmidt R, Schöttker B, Schulz CA, Schupf N, Shaffer CM, Shi Y, Smith AV, Smith BH, Soranzo N, Spracklen CN, Strauch K, Stringham HM, Stumvoll M, Svensson PO, Szymczak S, Tai ES, Tajuddin SM, Tan NYQ, Taylor KD, Teren A, Tham YC, Thiery J, Thio CHL, Thomsen H, Thorleifsson G, Toniolo D, Tönjes A, Tremblay J, Tzoulaki I, Uitterlinden AG, Vaccargiu S, van Dam RM, van der Harst P, van Duijn CM, Velez Edward DR, Verweij N, Vogelezang S, Völker U, Vollenweider P, Waeber G, Waldenberger M, Wallentin L, Wang YX, Wang C, Waterworth DM, Bin Wei W, White H, Whitfield JB, Wild SH, Wilson JF, Wojczynski MK, Wong C, Wong TY, Xu L, Yang Q, Yasuda M, Yerges-Armstrong LM, Zhang W, Zonderman AB, Rotter JI, Bochud M, Psaty BM, Vitart V, Wilson JG, Dehghan A, Parsa A, Chasman DI, Ho K, Morris AP, Devuyst O, Akilesh S, Pendergrass SA, Sim X, Böger CA, Okada Y, Edwards TL, Snieder H, Stefansson K, Hung AM, Heid IM, Scholz M, Teumer A, Köttgen A, Pattaro C.
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
Nat Genet. 2019 Jun;51(6):957-972. doi: 10.1038/s41588-019-0407-x. Epub 2019 May 31. PMID: 31152163; PMCID: PMC6698888.
PubMed

Cabrita, I., Benedetto, R., Schreiber, R., Kunzelmann, K.
Niclosamide repurposed for the treatment of inflammatory airway disease.
JCI Insight. 2019 Aug 8;4(15). pii: 128414. doi: 10.1172/jci.insight.128414.
PubMed

Wester M, Heller A, Gruber M, Maier LS, Schach C, Wagner S.
Glucocorticoid stimulation increases cardiac contractility by SGK1-dependent SOCE-activation in rat cardiac myocytes.
PLoS One. 2019 Sep 9;14(9):e0222341. doi: 10.1371/journal.pone.0222341. PMID: 31498847; PMCID: PMC6733454.
PubMed

Teumer A, Li Y, Ghasemi S, Prins BP, Wuttke M, Hermle T, Giri A, Sieber KB, Qiu C, Kirsten H, Tin A, Chu AY, Bansal N, Feitosa MF, Wang L, Chai JF, Cocca M, Fuchsberger C, Gorski M, Hoppmann A, Horn K, Li M, Marten J, Noce D, Nutile T, Sedaghat S, Sveinbjornsson G, Tayo BO, van der Most PJ, Xu Y, Yu Z, Gerstner L, Ärnlöv J, Bakker SJL, Baptista D, Biggs ML, Boerwinkle E, Brenner H, Burkhardt R, Carroll RJ, Chee ML, Chee ML, Chen M, Cheng CY, Cook JP, Coresh J, Corre T, Danesh J, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Degenhardt F, Dittrich K, Divers J, Eckardt KU, Ehret G, Endlich K, Felix JF, Franco OH, Franke A, Freedman BI, Freitag-Wolf S, Gansevoort RT, Giedraitis V, Gögele M, Grundner-Culemann F, Gudbjartsson DF, Gudnason V, Hamet P, Harris TB, Hicks AA, Holm H, Foo VHX, Hwang SJ, Ikram MA, Ingelsson E, Jaddoe VWV, Jakobsdottir J, Josyula NS, Jung B, Kähönen M, Khor CC, Kiess W, Koenig W, Körner A, Kovacs P, Kramer H, Krämer BK, Kronenberg F, Lange LA, Langefeld CD, Lee JJ, Lehtimäki T, Lieb W, Lim SC, Lind L, Lindgren CM, Liu J, Loeffler M, Lyytikäinen LP, Mahajan A, Maranville JC, Mascalzoni D, McMullen B, Meisinger C, Meitinger T, Miliku K, Mook-Kanamori DO, Müller-Nurasyid M, Mychaleckyj JC, Nauck M, Nikus K, Ning B, Noordam R, Connell JO, Olafsson I, Palmer ND, Peters A, Podgornaia AI, Ponte B, Poulain T, Pramstaller PP, Rabelink TJ, Raffield LM, Reilly DF, Rettig R, Rheinberger M, Rice KM, Rivadeneira F, Runz H, Ryan KA, Sabanayagam C, Saum KU, Schöttker B, Shaffer CM, Shi Y, Smith AV, Strauch K, Stumvoll M, Sun BB, Szymczak S, Tai ES, Tan NYQ, Taylor KD, Teren A, Tham YC, Thiery J, Thio CHL, Thomsen H, Thorsteinsdottir U, Tönjes A, Tremblay J, Uitterlinden AG, van der Harst P, Verweij N, Vogelezang S, Völker U, Waldenberger M, Wang C, Wilson OD, Wong C, Wong TY, Yang Q, Yasuda M, Akilesh S, Bochud M, Böger CA, Devuyst O, Edwards TL, Ho K, Morris AP, Parsa A, Pendergrass SA, Psaty BM, Rotter JI, Stefansson K, Wilson JG, Susztak K, Snieder H, Heid IM, Scholz M, Butterworth AS, Hung AM, Pattaro C, Köttgen A.
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.
Nat Commun. 2019 Sep 11;10(1):4130. doi: 10.1038/s41467-019-11576-0. PMID: 31511532; PMCID: PMC6739370.
PubMed

Schödel J, Ratcliffe PJ.
Mechanisms of hypoxia signalling: new implications for nephrology.
Nat Rev Nephrol. 2019 Oct;15(10):641-659. doi: 10.1038/s41581-019-0182-z. Epub 2019 Sep 5. Review.
Pubmed

Kunzelmann K, Centeio R, Wanitchakool P, Cabrita I, Benedetto R, Saha T, Hoque KM, Schreiber R.
Control of Ion Transport by Tmem16a Expressed in Murine Intestine.
Front Physiol. 2019 Oct 4;10:1262. doi: 10.3389/fphys.2019.01262.
Pubmed

Altenbuchinger M, Zacharias HU, Solbrig S, Schäfer A, Büyüközkan M, Schultheiß UT, Kotsis F, Köttgen A, Spang R, Oefner P, Krumsiek J, Gronwald W.
A multi-source data integration approach reveals novel associations between metabolites and renal outcomes in the German Chronic Kidney Disease study.
Sci. Reports. 2019 9, 13954 doi: 10.1038/s41598-019-50346-2
Pubmed

Tin A, Marten J, Halperin Kuhns VL, Li Y, Wuttke M, Kirsten H, Sieber KB, Qiu C, Gorski M, Yu Z, Giri A, Sveinbjornsson G, Li M, Chu AY, Hoppmann A, O'Connor LJ, Prins B, Nutile T, Noce D, Akiyama M, Cocca M, Ghasemi S, van der Most PJ, Horn K, Xu Y, Fuchsberger C, Sedaghat S, Afaq S, Amin N, Ärnlöv J, Bakker SJL, Bansal N, Baptista D, Bergmann S, Biggs ML, Biino G, Boerwinkle E, Bottinger EP, Boutin TS, Brumat M, Burkhardt R, Campana E, Campbell A, Campbell H, Carroll RJ, Catamo E, Chambers JC, Ciullo M, Concas MP, Coresh J, Corre T, Cusi D, Felicita SC, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Delgado G, Demirkan A, Devuyst O, Dittrich K, Eckardt KU, Ehret G, Endlich K, Evans MK, Gansevoort RT, Gasparini P, Giedraitis V, Gieger C, Girotto G, Gögele M, Gordon SD, Gudbjartsson DF, Gudnason V; German Chronic Kidney Disease Study, Haller T, Hamet P, Harris TB, Hayward C, Hicks AA, Hofer E, Holm H, Huang W, Hutri-Kähönen N, Hwang SJ, Ikram MA, Lewis RM, Ingelsson E, Jakobsdottir J, Jonsdottir I, Jonsson H, Joshi PK, Josyula NS, Jung B, Kähönen M, Kamatani Y, Kanai M, Kerr SM, Kiess W, Kleber ME, Koenig W, Kooner JS, Körner A, Kovacs P, Krämer BK, Kronenberg F, Kubo M, Kühnel B, La Bianca M, Lange LA, Lehne B, Lehtimäki T; Lifelines Cohort Study, Liu J, Loeffler M, Loos RJF, Lyytikäinen LP, Magi R, Mahajan A, Martin NG, März W, Mascalzoni D, Matsuda K, Meisinger C, Meitinger T, Metspalu A, Milaneschi Y; V. A. Million Veteran Program, O'Donnell CJ, Wilson OD, Gaziano JM, Mishra PP, Mohlke KL, Mononen N, Montgomery GW, Mook-Kanamori DO, Müller-Nurasyid M, Nadkarni GN, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Noordam R, O'Connell JR, Olafsson I, Padmanabhan S, Penninx BWJH, Perls T, Peters A, Pirastu M, Pirastu N, Pistis G, Polasek O, Ponte B, Porteous DJ, Poulain T, Preuss MH, Rabelink TJ, Raffield LM, Raitakari OT, Rettig R, Rheinberger M, Rice KM, Rizzi F, Robino A, Rudan I, Krajcoviechova A, Cifkova R, Rueedi R, Ruggiero D, Ryan KA, Saba Y, Salvi E, Schmidt H, Schmidt R, Shaffer CM, Smith AV, Smith BH, Spracklen CN, Strauch K, Stumvoll M, Sulem P, Tajuddin SM, Teren A, Thiery J, Thio CHL, Thorsteinsdottir U, Toniolo D, Tönjes A, Tremblay J, Uitterlinden AG, Vaccargiu S, van der Harst P, van Duijn CM, Verweij N, Völker U, Vollenweider P, Waeber G, Waldenberger M, Whitfield JB, Wild SH, Wilson JF, Yang Q, Zhang W, Zonderman AB, Bochud M, Wilson JG, Pendergrass SA, Ho K, Parsa A, Pramstaller PP, Psaty BM, Böger CA, Snieder H, Butterworth AS, Okada Y, Edwards TL, Stefansson K, Susztak K, Scholz M, Heid IM, Hung AM, Teumer A, Pattaro C, Woodward OM, Vitart V, Köttgen A.
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
Nat Genet. 2019 Oct;51(10):1459-1474. doi: 10.1038/s41588-019-0504-x. Epub 2019 Oct 2. PMID: 31578528; PMCID: PMC6858555.
PubMed

Lauer V, Grampp S, Platt J, Lafleur V, Lombardi O, Choudhry H, Kranz F, Hartmann A, Wullich B, Yamamoto A, Coleman ML, Ratcliffe PJ, Mole DR, Schödel J.
Hypoxia drives glucose transporter 3 expression through HIF-mediated induction of the long non-coding RNA NICI.
J Biol Chem. 2019 Nov 5. pii: jbc.RA119.009827. doi: 10.1074/jbc.RA119.009827. [Epub ahead of print]
Pubmed

Ousingsawat J, Schreiber R, Kunzelmann K.
TMEM16F/Anoctamin 6 in Ferroptotic Cell Death.
Cancers 2019, 11(5), 625; doi.org/10.3390/cancers11050625 (registering DOI)
Pubmed

Fandrey J, Schödel J, Eckardt KU, Katschinski DM, Wenger RH.
Now a Nobel gas: oxygen.
Pflugers Arch. 2019 Nov 22. doi: 10.1007/s00424-019-02334-8. [Epub ahead of print] Review.
Pubmed

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