Forschung
Summary
Chromatin remodelers are key players in the regulation of chromatin accessibility and nucleosome positioning on the eukaryotic DNA, therefore they are essential for all DNA dependent biological processes. There are mounting evidence that variety of cancers employ chromatin remodelers: they can be downregulated or even lacking functional protein, overexpressed, carry somatic mutations or support cancer through the interaction with long noncoding RNA. In parallel, the promise of epigenetic therapies is growing. It seems that targeting and exploring the pharmaceutical potential of deregulated chromatin remodeling machines might lead to more efficient personalized cancer therapies.
We are studying chromatin remodeling complexes and trying to further understand the mechanisms of how chromatin remodelers act in cancer using a combination of biochemical, molecular biology, genetic and mammalian cell culture techniques. In collaboration with 2bind company we are characterizing the cancer occurring mutations in chromatin remodelers.
Kurz-CV
Laura Manelyte - Kurz-CV
| seit 2023 | Principal Investigator an der Universität Regensburg, Biochemie III |
| 2023 | Habilitation an der Universität Regesnburg, Biochemie III (Prof. G. Längst) |
| seit 2016 | Principal Investigator (gefördert durch die DFG) an der Universität Regensburg, Biochemie III |
| 2014 - 2015 | Postdoktorandin (Stipendium des Bayerischen Ministeriums "Programm zur Realisierung der Chancengleichheit für Frauen in Forschung und Lehre") an der Universität Regensburg, Biochemie III (Prof. G. Längst) |
| 2009 - 2013 | Postdoktorandin an der Universität Regensburg, Biochemie III (Prof. G. Längst) |
| 2007 - | Postdoktorandin at the University of Bristol (UK), School of Biochemistry (Prof. N.Savery) |
| 2003 - 2006 | Promotion (Dr.rer.nat, summa cum laude) an der Justus-Liebig Universität Giessen (Germany), Department of Biochemistry (Prof. P.Friedhoff and Prof. A.Pingoud) |
Awards and News
October 2024
Robertas Pranevičius, a PhD student in biology at the Institute of Cardiology at the Lithuanian University of Health Sciences and a cardiologist at the Hospital of the Lithuanian University of Health Sciences "Kauno Klinikos," had a short stay at Biochemistry III, University of Regensburg from October 1 to 12, 2024. The exchange was a valuable experience for both parties, fostering collaboration and shared insights. Discussions ranged from teaching medical students to exploring epigenetics in cardiology. The experience and knowledge gained during this stay will be applied in a forthcoming research project titled "The Link between Coronary Artery Disease, Bacteria, and Viruses" (Principal Investigator: Dr. Vacis Tatarūnas).
#internationality
#interdisciplinarity
#epigenetics
#cardiology
#the translational gap: bridging basic research and clinical practices
November 2023
Many thanks to the Mayor of the City of Regensburg and the University of Regensburg for awarding me the Prize for Women in Science and the Arts.
It was an impressive event at the Old Town Hall of Regensburg, and I was grateful for the opportunity to share my research with the audience.
Thank you, City of Regensburg!
Photography by Stadt Regensburg, Christian Kaister
January 2023
Discovery of the year!
Nominated by the Lithuanian Radio and Television in Annual Award.
Together with:
Dr. Migle Tomkuviene
Prof. Saulius Klimasauskas
Click here for our work on nucleosomes on synthetically modified DNA.
Publikationen
Förderung
Kontakt
PD Dr. Laura Manelyte-Aldehni
Lehrstuhl Biochemie III
Biochemie-Zentrum Regensburg
Universität Regensburg
Universitätsstr. 31
Raum: VKL 5.0.18
93053 Regensburg
T: +49 941 943 2539
F: +49-941-943-2474
E: laura.manelyte@ur.de
