Prof. Dr. Stefan Dove (im Ruhestand)

Prof. Dr. Stefan Dove

E-Mail stefan.dove@ur.de

Forschungsschwerpunkte:

• Computer-Aided Drug Research (Quantitative Structure-Activity Relationships, especially 3D-QSAR approaches, Molecular Modeling)
• Structure-activity relationships and binding models of ligands of G-protein coupled receptors (GPCR homology models, docking, 3D-QSAR), in particular: agonists and antagonists of histamine-H2-, H4-, 5HT2A-, beta-adrenergic and  neuropeptide Y Y1-receptors, modeling of active receptor states
• Inhibitors of receptor tyrosine kinases (modeling and structure-based design); grant from Deutsche Krebshilfe e.V. / Dr. Mildred Scheel Stiftung für Krebsforschung (2001 - 2005)
• Inhibitors of bacterial hyaluronan lyases and human hyaluronidases (modeling and structure-based design)
• Substituted nucleotides as inhibitors of bacterial and human adenylyl cyclases – modeling of ligand-enzyme interactions

Zusätzliche Forschungsinteressen:

• Modeling and prediction of protein-protein interactions (e.g., of TIR domains)
• Receptor theory