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Neva Caliskan


neva.caliskan@ur.de
Phone: +49 (941) 943 2472
Room: VKL 5.0.16

Research Prof. Caliskan

Research Prof. Dr Neva Caliskan

Neva Caliskan's research group investigates the role of RNA molecules in non-canonical translation events that can influence the interplay between host and pathogen. Her aim is to shed light on therapeutic RNA-protein complexes as new targets in the fight against infections.

RNAs encoded in viruses or cellular genes can be read in an alternative way during translation, which is known as recoding. However, it is unclear how exactly recoding is regulated by the host. A precise understanding of recoding and its regulation may therefore be the key to developing new RNA-based therapies in the fight against infections.

In this context, Neva Caliskan's group is investigating the function and dynamics of RNA molecules and how they interact with trans-acting factors. The scientists are working with viruses such as coronaviruses and retroviruses, which are known to be dependent on recoding for their replication. Together, they are developing methods to investigate RNA complexes and translation in unprecedented detail.

The group uses a highly interdisciplinary toolset, such as RNA antisense purification and mass spectrometry, to recognise RNA interaction partners and to study cellular assays in molecular detail. Assays for single molecules or groups of molecules such as optical tweezers play an important role in the study of RNA complexes.

In order to advance the development of RNA-based therapies, the scientists want to understand how RNA structural elements interact with other factors in the cell to regulate the way mRNA is read by the ribosomes.

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Neva Caliskan


neva.caliskan@ur.de
Phone: +49 (941) 943 2472
Room: VKL 5.0.16