Publications
| Fakultät für Biologie und Vorklinische Medizin |
| Institut für Zoologie |
| Lehrstuhl für Entwicklungsbiologie |
| Publications |
Veröffentlichungen
Publikationen (1990- )
Rodríguez LR, Calap-Quintana P, Lapeña-Luzón T, Pallardó FV, Schneuwly S, Navarro JA, Gonzalez-Cabo P. (2020) Oxidative stress modulates rearrangement of endoplasmic reticulum-mitochondria contacts and calcium dysregulation in a Friedreich's ataxia model. Redox Biol. 101762. doi: 10.1016/j.redox.2020.101762. Epub 2020 Oct 16. PMID: 33128998
Rass M, Oestreich S, Manaj A, Schneuwly S. (2019) Loss of fuss in Drosophila melanogaster results in decreased locomotor activity due to an increased number of pauses. MicroPubl Biol. 2020:10.17912/micropub.biology.000230. doi: 10.17912/micropub.biology.000230. PMID: 32550504; PMCID: PMC7252353.
Rallis A, Navarro JA, Rass M, Hu A, Birman S, Schneuwly S, Thérond PP. (2019) Hedgehog Signaling Modulates Glial Proteostasis and Lifespan. Cell Rep. 30(8):2627-2643.e5. doi: 10.1016/j.celrep.2020.02.006. PMID: 32101741.
Rass M, Oestreich S, Guetter S, Fischer S, Schneuwly S. (2019)The Drosophila fusel gene is required for bitter gustatory neuron differentiation acting within an Rpd3 dependent chromatin modifying complex. PLoS Genet. 15(2):e1007940. doi: 10.1371/journal.pgen.1007940. PMID: 30730884; PMCID:PMC6382215.
Moschall R, Rass M, Rossbach O, Lehmann G, Kullmann L, Eichner N, Strauss D, Meister G, Schneuwly S, Krahn MP, Medenbach J. (2019) Drosophila Sister-of-Sex-lethal reinforces a male-specific gene expression pattern by controlling Sex-lethal alternative splicing. Nucleic Acids Res. 47(5):2276-2288. Doi 10.1093/nar/gky1284. PMID: 30590805; PMCID: PMC6411925.
Edenharter, O., Schneuwly, S and Navarro, J.A. (2018). Mitofusin-dependent ER stress triggers glial dysfunction and nervous system degeneration in a Drosophila model of Friedreich’s ataxia. Frontiers in Molecular Neurosciences. doi:10.3389/fnmol.2018.00038.
Navarro, J.A and Schneuwly, S. (2017). Copper and Zinc homeostasis: Lessons from Drosophila melanogaster. Review. Frontiers in Genetics. doi: 10.3389/fgene.2017.00223.
Edenharter, O., Schneuwly, S and Navarro, J.A. (2017). Overexpression of Drosophila frataxin triggers neurodegeneration in an iron-dependent manner. Journal of Neurogenetics. 24:1-14.
Franco, C., Genis, L., Navarro, J.A., Perez-Domper, P., Fernandez, A.M., Schneuwly, S., Torres Aleman, I. (2017) A role for astrocytes in cerebellar deficits in Frataxin deficiency: Protection by insulin-like growth factor I. Mol. Cell. Neurosci. 80, 100-110
Navarro, J.A., Botella, J.A., Metzendorf, C., Lind, M.I., Schneuwly S. (2015) Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich's ataxia. Free Radic. Biol. Med. 85, 71-82.
Navarro JA, Heßner, S, Yenisetti SC, Bayersdorfer F, Zhang L, Voigt A, Schneuwly S and Botella JA (2014) Analysis of dopaminergic neuronal dysfunction in genetic and toxin-induced models of Parkinson’s disease in Drosophila. J. Neurochem. 131(3) 369-382.
Rowshanravan B, Woodcock SA, Botella JA, Kiermayer, C, Schneuwly S, Hughes D (2014) RasGAP mediates neuronal survival in Drosophila through direct regulation of Rab5-dependent endocytosis. J. Cell Science 127, 2849-2861.
Kosmidis S, Missirilis, F, Botella JA, Schneuwly S, Rouault, TA, Skoulakis EM (2014) Behavioral decline and premature lethality upon pan-neuronal ferritin overexpression in Drosophila infected with a virulent form of Wolbachia. Frontiers in pharmacology 5:66, doi:10.3389/fphar.2014.00066.
Stockmann M, Meyer-Ohlendorf M, Achberger K, Putz S, Demestre M, Yin H, Hendrich C, Linta L, Heinrich J, Brunner C, Proepper C, Kuh GF, Baumann B, Langer T, Schwalenstöcker B, Braunstein K, von Arnim C, Schneuwly S, Meyer T, Wong PC, Boeckers TM, Ludolph AC, Liebau S (2013) The dynactin p150 subunit: cell biology studies of sequence changes found in ALS/MND and Parkinsonian Syndromes. J. Neural Transm. 120:785-798, doi: 10.1007/s00702-012-0910-z.
Fischer S, Bayersdorfer F, Harant E, Reng R, Arndt S, Bosserhoff AK, Schneuwly S (2012) fussel (fuss) – A Negative Regulator of BMP Signaling in Drosophila melanogaster PLoS ONE 7(8):e42349. doi:10.1371/journal.pone.0042349.
Kosmidis S, Botella JA, Mandilaras K, Schneuwly S, Skoulakis EM, Rouault TA, Missirlis F (2011) Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioural defects. Neurobiol Dis. 43:213-219. doi:10.1016/j.nbd.2011.03.013
Navarro JA, Llorens, JV, Soriano S, Botella JA, Schneuwly S, Martinez-Sebastian, MJ, Molto MD (2011) Overexpression of Human and Fly Frataxins in Drosophila Provokes Deleterious Effects at Biochemical, Physiological and Developmental Levels. PLoS ONE 6(7):e21017. doi:10.1371/journal.pone.0021017
Martin HJ, Ziemba M, Kisiela M, Botella JA, Schneuwly S, Maser E (2010) The Drosophila carbonyl reductase sniffer is an efficient 4-oxonon-2-enal (4ONE) reductase. Chem Biol Interact. 191(1-3):48-54. doi:10.1016/j.cbi.2010.12.006
Navarro JA, Ohmann E, Sanchez D, Botella JA, Liebisch G, Moltó MD, Ganfornina MD, Schmitz G, Schneuwly S (2010) Altered lipid metabolism in a Drosophila model of Friedreich's ataxia. Human Mol Genetics 19(14):2828-2840.
Bayersdorfer F, Voigt A, Schneuwly S, Botella JA (2010) Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease. Neurobiol Dis 40:113-119.
Botella JA, Bayersdorfer F, Gmeiner F, Schneuwly S (2009) Modelling Parkinson's disease in Drosophila. Neuromol Med 11(4):1535-1084.
Gruenewald C, Botella JA, Bayersdorfer F, Navarro JA, Schneuwly S (2009) Hyperoxia induced neurodegeneration as a tool to identify neuroprotective genes in Drosophila melanogaster. Free Radic Biol Med 46:1668-1676.
Hofbauer A, Ebel T, Waltenspiel B, Oswald P, Chen Y, Halder P, Biskup S, Lewandrowski U, Winkler C, Sickmann A, Buchner S, Buchner E (2009) The Wuerzburg hybridoma library against Drosophila brain. J Neurogenet 23:78-91.
Botella JA, Bayersdorfer F, Schneuwly S. (2008) Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease. Neurobiol Dis 30:65-73.
Llorens JV, Navarro JA, Martinez-Sebastian MJ, Baylies MK, Schneuwly S, Botella JA, Molto MD (2007) Causative role of oxidative stress in a Drosophila model of Friedreich ataxia. FASEB J 21:333-344.
Collins B, Mazzoni EO, Stanewsky R, Blau J (2006) Drosophila CRYPTOCHROME is a circadian transcriptional repressor. Curr Biol 16:441-449.
Peschel N, Veleri S, Stanewsky R (2006) Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadien clock. Proc Natl Acad Sci USA 103:17313-17318.
Wagh DA, Rasse TM, Asan E, Hofbauer A, Schwenkert I, Dürrbeck H, Buchner S, Dabauvalle MC, Schmidt M, Qin G, Wichmann C, Kittel R, Sigrist SJ, Buchner E. (2006) Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila. Neuron 49:833-844.
Glaser F., Stanewsky R. (2005) Temperature Synchronization of the Drosophila Circadian Clock. Curr Biol. 15(15):1352-1363
Franzen C, Fischer S, Schroeder J, Bleiss W, Schneuwly S, Scholmerich J, Salzberger B. (2005) In vitro cultivation of an insect microsporidian Tubulinosema ratisbonensis in mammalian cells. J Eukaryot Microbiol 52:349-55.
Franzen C, Fischer S, Schroeder J, Scholmerich J, Schneuwly S. (2005) Morphological and molecular investigations of Tubulinosema ratisbonensis gen. nov., sp. nov. (Microsporidia: Tubulinosematidae fam. nov.), a parasite infecting a laboratory colony of Drosophila melanogaster (Diptera: Drosophilidae). J Eukaryot Microbiol 52:141-52.
Wülbeck C, Szabo G, Shafer OT, Helfrich-Forster C, Stanewsky R. (2005) The novel Drosophila tim(blind) mutation affects behavioral rhythms but not periodic eclosion. Genetics 169(2):751-66
Veleri S, Wulbeck C. (2004) Unique self-sustaining circadian oscillators within the brain of Drosophila melanogaster. Chronobiol Int 21(3):329-42. Review.
Botella JA, Schneuwly S (2004) Drosophila melanogaster: Ein Modellsystem zur Analyse neurodegenerativer Erkrankungen. Biospektrum 5:626-628.
Sgraja T, Ulschmid J, Becker K, Schneuwly S, Klebe G, Reuter K, Heine A. (2004) Structural insights into the neuroprotective-acting carbonyl reductase Sniffer of Drosophila melanogaster. J Mol Biol 342:1613-24.
Botella JA, Ulschmid JK, Gruenewald C, Moehle C, Kretzschmar D, Becker K, Schneuwly S. (2004) The Drosophila carbonyl reductase sniffer prevents oxidative stress-induced neurodegeneration. Curr Biol. 14(9):782-6.
Ryder E, Blows F, Ashburner M, Bautista-Llacer R, Coulson D, Drummond J, Webster J, Gubb D, Gunton N, Johnson G, O'Kane CJ, Huen D, Sharma P, Asztalos Z, Baisch H, Schulze J, Kube M, Kittlaus K, Reuter G, Maroy P, Szidonya J, Rasmuson-Lestander A, Ekstrom K, Dickson B, Hugentobler C, Stocker H, Hafen E, Lepesant JA, Pflugfelder G, Heisenberg M, Mechler B, Serras F, Corominas M, Schneuwly S, Preat T, Roote J, Russell S. (2004) The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster. Genetics 167:797-813.
Rieger D, Stanewsky R, Helfrich-Forster C. (2003) Cryptochrome, compound eyes, Hofbauer-Buchner eyelets, and ocelli play different roles in the entrainment and masking pathway of the locomotor activity rhythm in the fruit fly Drosophila melanogaster. J Biol Rhythms 18(5):377-91.
Veleri S, Brandes C, Helfrich-Forster C, Hall JC, Stanewsky R. (2003) A self-sustaining, light-entrainable circadian oscillator in the Drosophila brain. Curr Biol 13(20):1758-67.
Stanewsky R. (2003) Genetic Analysis of the Circadian System in Drosophila melanogaster and Mammals. J Neurobiol 54:111-147 Review
Botella JA, Kretzschmar D, Kiermayer C, Feldmann P, Hughes DA, Schneuwly S (2003) Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap. Mol Biol Cell 14(1):241-50
Botella JA (2003) ¿Es la vacuna la terapia adecuada? Enfermeria Global 2.
Stanewsky R, Lynch KS, Brandes C, Hall JC (2002) Mapping of Elemnents Involved in Regulating Normal Temporal period and timeless RNA Expression Patterns in Drosophila melanogaster. J Biol Rhythms 17(4):293-306
Stanewsky R (2002) Clock mechanisms in Drosophila. Cell Tissue Res 309:11-26 Review
Helfrich-Förster C, Edwards T, Yasuyama K, Wisotzki B, Schneuwly S, Meinertzhagen IA. Hofbauer A (2002) The extraretinal eyelet of Drosophila: development, ultrastructure and putative circadian function. J Neurosci 22(21):9255-9266
Stempfl T, Vogl M, Szabo G, Wuelbeck C, Liu J, Hall JC, Stanewsky R (2002) Identification of circadian-clock regulated enhancers and genes of Drosophila melanogaster by transposon mobilization and luciferase reporting of cyclical gene expression. Genetics 160(2):571-93
Ivanchenko M, Stanewsky R, Giebultowicz JM (2001) Circadian Photoreception in Drosophila: Functions of Cryptochrome in Peripheral and Central Clocks. J Biol Rhythms 16:205-215.
Helfrich-Förster Ch, Winter C, Hofbauer A, Hall JC, Stanewsky R (2001) The circadian clock of fruitflies is blind after elimination of all known photoreceptors. Neuron 30:249-261.
Botella JA, Baines IA, Williams DD, Goberdhan DCI, Proud CG, Wilson C (2001) The Drosophila cell shape regulator c-Jun N-terminal kinase also functions as a stress-activated protein kinase. Insect Biochem Mol Biol 31:839-847.
Maier D, Farr CL, Poeck B, Alahari A, Vogel M, Fischer S, Kaguni LS, Schneuwly S (2001) Mitochondrial single-stranded DNA-binding protein is required for mitochondrial DNA replication and development in Drosophila melanogaster. Mol Biol Cell 12(4):821-30.
Kanzok SM, Fechner, A, Bauer H, Ulschmid JK, Möller H-M, Botella-Munoz J, Schneuwly S, Schirmer RH Becker K (2001) Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster. Science 291:643-646.
Kretzschmar D, Poeck B, Roth H, Ernst R, Keller A, Porsch M, Strauss R, Pflugfelder GO (2000) Defective pigment granule biogenesis and aberrant behavior caused by mutations in the Drosophila AP-3beta adaptin gene ruby. Genetics 155(1):213-23.
Moser M, Stempfl T, Li Y, Glynn P, Buttner R, Kretzschmar D (2000) Cloning and expression of the murine sws/NTE gene. Mech Dev 90(2):279-82.
Emery P, Stanewsky R, Helfrich-Förster C, Emery-Le M, Hall JC, Rosbash M (2000) Drosophila CRY is a deep brain circadian photoreceptor. Neuron 26(2):493-504.
Giebultowicz JM, Stanewsky R, Hall JC, Hege DM (2000). Transplanted Drosophila excretory tubules maintain circadian clock cycling out of phase with the host. Curr Biol 10:107-110.
Helfrich-Förster C, Täuber M, Park JH, Mühlig-Versen M, Schneuwly S, Hofbauer A (2000) Ectopic expression of the neuropeptide pigment-dispersing factor alters behavioral rhythms in Drosophila melanogaster. J Neurosci 20(9):3339-3353.
Emery P, Stanewsky R, Hall JC, Rosbash M (2000) A unique circadian-rhythm photoreceptor. Nature 404:456-457.
Li, Ch., Geng, Ch., Leung, H-T., Hong, Y.S., Strong, L.R., Schneuwly, S., and Pak, W.L. (1999)INAF, a protein required for transient receptor potential CA2+ channel function. Proc. Natl. Acad. Sci. 96:13474-13479.
Reim I, Stanewsky R, Saumweber H(1999) The puff-specific RRM protein NONA is a singlestranded nucleic acid binding protein. Chromosoma 108:162-72.
Eberle, K. K., Zinsmaier, K. E., Buchner, S., Gruhn, M., Jenni, M., Arnold, C., Leibold, C., Reisch, D., Walter, N., Hafen, E., Hofbauer, A., Pflugfelder, G. O., and Buchner, E. (1998) Wide distribution of the cysteine string proteins in Drosophila tissues revealed by targeted mutagenesis. Cell Tissue Res. 294:203-17.
Stanewsky, R., Kaneko, M., Emery, P., Beretta, B., Wager-Smith, K., Kay, S.A., Rosbash, M., and Hall, J.C. (1998) The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell 95:681-92.
Albert, S., Twardzik, T., Heisenberg, M., and Schneuwly, S. (1997) Isolation and characterization of the droPIK57 gene encoding a new regulatory subunit of phosphatidylinositol 3-kinase from Drosophila melanogaster. Gene 198:181-9.
Hege, D.M., Stanewsky, R., Hall, J.C., and Giebultowicz, J.M. (1997) Rhythmic expression of a PER-reporter in the Malpighian tubules of decapitated Drosophila: evidence for a brain-independent circadian clock. J. Biol. Rhythms 12:300-8.
Ito, K., Sass, H., Urban, J, Hofbauer, A., Schneuwly, S. (1997) GAL4-responsive UAS-tau as a tool for studying the anatomy and development of the Drosophila central nervous system. Cell Tissue Res 290:1-10.
Kretzschmar, D., Hasan, G., Sharma, S., Heisenberg, M. and Benzer S. (1997)The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila. J. Neuroscience 17: 7425-7432.
Plautz, J.D., Straume, M., Stanewsky, R., Jamison, C.F., Brandes, C., Dowse, H.B., Hall, J.C., and Kay, S.A. (1997) Quantitative analysis of Drosophila period gene transcription in living animals. J. Biol. Rhythms 12:204-17.
Dembinska, M.E., Stanewsky, R., Hall, J.C., and Rosbash, M. (1997) Circadian cycling of a period-beta-galactosidase fusion protein in Drosophila: evidence for cyclical degradation. J. Biol. Rhythms 12:157-72.
Stanewsky, R., Frisch, B., Brandes, C., Hamblen-Coyle, M.J., Rosbash, M., and Hall, J.C. (1997) Temporal and spatial expression patterns of transgenes containing increasing amounts of the Drosophila clock gene period and a lacZ reporter: mapping elements of the PER protein involved in circadian cycling. J. Neurosci. 17:676-96.
Stanewsky. R., Jamison, C.F., Plautz, J.D., Kay, S.A., and Hall, J.C. (1997) Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila. EMBO J., 16:5006-18.
Brandes, C., Plautz, J.D., Stanewsky, R., Jamison, C.F., Straume, M., Wood, K.V., Kay, S.A., and Hall, J.C. (1996) Novel features of Drosophila period Transcription revealed by real-time luciferase reporting. Neuron 16: 687-92.
Klagges, B. R., Heimbeck, G., Godenschwege, T. A., Hofbauer, A., Pflugfelder, G.O., Reifegerste, R., Reisch, D., Schaupp, M., Buchner, S., and Buchner, E. (1996) Invertebrate synapsins: a single gene encodes for several isoforms in Drosophila. J. Neurosci. 16: 31554-65.
Schneuwly, S. (1996) Pfadfinder im Gehirn? Entwicklungs- und Neurogenetik komplexer Nervensysteme. Blick in die Wissenschaft.Universitätsverlag Regensburg. 5 Heft 8:12-21.
R. Stanewsky, T.A. Fry, I. Reim, H. Saumweber, and J.C. Hall (1996). Bioassaying putative RNA-binding motifs in a protein encoded by a gene that influences courtship and visually mediated behavior in Drosophila: in vitro mutagenesis of nonA. Genetics 143: 259-275.
Reichmuth, C., Becker, S., Benz, M., Debel, K., Reisch, D., Heimbeck, G., Hofbauer, A., Klagges, B., Pflugfelder, G.O., and Buchner, E. (1995) The sap47 gene of Drosophila melanogaster codes for a novel conserved neuronal protein associated with synaptic terminals. Brain Res. Mol. Brain Res. 32:45-54.
Martin, K.A., Poeck, B., Roth, H., Ebens, A.J., Conley Ballard, L., and Zipursky, S.L. (1995) Mutations disrupting neuronal connectivity in the Drosophila visual system. Neuron 14:229-240.
Botella JA, Murillo F, Ruiz-Vazquez (1995) A cluster of structural and regulatory genes for light-induced carotenogenesis in Myxococcus xanthus. Eu J Biochem 233:238-248.
Kerscher, S., Albert, S., Wucherpfennig, D., Heisenberg, M., and Schneuwly, S. (1995) Molecular and Genetic Analysis of the Drosophila mas-1 (mannosidase-1) gene which encodes a glycoprotein processing a1,2 mannosidase. Dev. Biol. 168:613-626.
Brunner, A., Twardzik, T., Schneuwly, S. (1994) The Drosphila giant lens gene plays a dual role in eye and optic lobe development: Inhibition of differentiation of ommatidials cells and interference in photoreceptor axon guidance. Mech. of Dev. 48:175-185.
Störtkuhl, K.F., Hofbauer, A., Gendre, N., Keller, V., Stocker, R.F. (1994) Analysis of immunocytochemical staining patterns in the antennal system of Drosophila melanogaster. Cell Tissue Res. 275:27-38.
Bicker, G., Kreissl, S., Hofbauer, A. (1993) Monoclonal antibody labels olfactory and visual pathways in Drosophila and Apis brains. J. Comp. Neurol. 335:413-424.
R. Stanewsky, K.G. Rendahl, M. Dill, and H. Saumweber (1993). Genetic and molecular Analysis of the X chromosomal region 14B17-14C4 in Drosophila melanogaster: loss of function in NONA, a nuclear protein common to many cell types, results in specific physiological and behavioral defects. Genetics 135: 419-442.
Buchner, E., Buchner, S., Burg, M.G., Hofbauer, A., Pak, W.L., Pollack, I. (1993) Histamine is a major mechanosensory neurotransmitter candidate in Drosophila melanogaster. Cell Tissue Res. 273:119-125.
Poeck, B., Hofbauer, A., Pflugfelder, G.O. (1993) Expression of the Drosophila optomotor-blind gene transcript in neuronal and glial cells of the developing nervous system. Development 117:1017-1029.
Poeck, B., Balles, J., Pflugfelder, G.O. (1993) Transcript identification in the optomotor-blind locus of Drosophila melanogaster by intragenic recombination mapping and PCR-aided sequence analysis of lethal point mutations. Mol. Gen. Genet. 238:325-332.
Reifegerste, R., Grimm, S., Albert, S., Lipski, N., Heimbeck, G. Hofbauer, A., Pflugfelder, G.O., Quack, D., Reichmuth, C., Schug, B., Zinsmeier, K.E., Buchner, S., Buchner, E. (1993) An invertebrate calcium-binding protein of the calbindin subfamily: protein structure, genomic organization, and expression pattern of the calbindin-32 gene of Drosophila. J. Neurosci. 13:2186-2198.
Brunner, A., Wolf, R., Pflugfelder, G.O., Poeck, B., Heisenberg, M. (1992) Mutations in the proximal region of the optomotor-blind locus of Drosophila melanogaster reveal a gradient of neuroanatomical and behavioral phenotypes. J. Neurogenet. 8:43-55.
Engstr�m, Y., Schneuwly, S., Gehring, W.J. (1992) Spatial and temporal expression of an Antennapedia/lac Z gene construct integrated into the endogenous Antennapedia gene of Drosophila melanogaster. Roux's Arch. Dev. Biol. 201:65-80.
Kretzschmar, D., Brunner, A., Wiersdorff, V., Pflugfelder, G.O., Heisenberg, M., Schneuwly, S. (1992) Giant lens, a gene involved in cell determination and axon guidance in the visual system of Drosophila melanogaster. EMBO J. 11:2531-2539.
Pflugfelder, G.O., Roth, H., Poeck, B. (1992) A homology domain shared between Drosophila optomotor-blind and mouse Brachyury is involved in DNA binding. Biochem. Biophys. Res. Commun. 186:918-925.
Pflugfelder, G.O., Roth, H., Poeck, B., Kerscher, S., Schwarz, H., Jonschker, B., Heisenberg, M. (1992) The lethal(1)optomotor-blind gene of Drosophila melanogaster is a major organizer of optic lobe development: Isolation and characterization of the gene. PNAS 89:1199-1203.
Pollack, I., Hofbauer, A. (1991) Histamine-like immunoreactivity in the visual system and brain of Drosophila melanogaster. Cell Tissue Res. 266:391-398.
Reifegerste, R., Faust, C., Lipski, N., Heimbeck, G., Hofbauer, A., Pflugfelder O.G., Zinsmaier, K., Heizmann, C.W., Buchner, S., Buchner, E. (1991) A novel EF-hand Ca[2+]-binding protein is expressed in discrete subsets of muscle and nerve cells of Drosophila. In: Heizmann, C.W. (ed). Novel Calcium-Binding Proteins. Fundamentals and Clinical Implications. Springer Verlag, Berlin Heidelberg New York: 505-509.
Schneuwly, S., Burg, M.G., Lending, C., Perdew, M.H., Pak, W.L. (1991) Properties of photoreceptor-specific phospholipase C encoded by the norpA gene of Drosophila melanogaster. J. Biol. Chem. 266:24314-24319.
Hofbauer, A., Campos-Ortega, J.A. (1990) Proliferation pattern and early differentiation of the optic lobes in Drosophila melanogaster. Roux's Arch. Dev. Biol. 198:264-274.
Pflugfelder, G.O., Schwarz, H., Roth, H., Poeck, B., Sigl, A., Kerscher, S., Jonschker, B., Pak, W.L., Heisenberg, M. (1990) Genetic and molecular characterization of the optomotor-blind gene locus in Drosophila melanogaster. Genetics 126:91-104.
Zinsmaier, K.E., Hofbauer, A., Heimbeck, G., Pflugfelder, G.O., Buchner, S., Buchner, E. (1990) A cysteine-string protein is expressed in retina and brain of Drosophila. J. Neurogenet. 7:15-29.
H.v. Besser, P. Schnabel, C. Wieland, E. Fritz, R. Stanewsky, and H. Saumweber (1990). The puff-specific Drosophila Protein Bj6, encoded by the gene no-on-transient A, shows homology to RNA-binding proteins. Chromosoma 100: 37-47.
Doktorarbeiten
Dissertationen
| Schramm, Mathias (2021) | Molecular and functional analysis of the gene snoo in Drosophila melanogaste |
| Edenharter, Oliver (2017) | In vivo analysis of the mitochondrial protein frataxin in Drosophila melanogaster |
| Raß, Matthias (2016) | Funktionelle Analyse von Fussel während der Entwicklung des Nervensystems in Drosophila melanogaster |
| Heßner, Sabine (2016) | Funktionelle Analyse des ATP13A2 Orthologs in D. melanogaster |
| Bleyl, Cornelia | Ein Drosophila-Modell der Amyotrophen Lateralsklerose zur Identifizierung pathogener DCTN1-Mutationen |
| Bayersdorfer, Florian (2009) | Die Bedeutung von oxidativem Stress bei hereditären und sporadischen Formen der Parkinson'schen Krankheit. Eine Studie an Drosophila melanogaster. |
| Mügschl, Monika (2008) | Charakterisierung molekularer und genetischer Interaktionen von RasGAP in Drosophila melanogaster: Untersuchungen zur Neurodegenerationsmutante vap. |
| Landskron, Johannes (2007) | Untersuchungen zu den Uhrproteinen PERIOD und TIMELESS aus der Fruchtfliege Drosophila melanogaster. |
| Glaser, Franz (2006) | Temperatursynchronisation der circadianen Uhr von Drosophila melanogaster: Eine genetische und molekulare Untersuchung beteiligter Mechanismen und Rezeptoren. |
| Grünewald, Christoph (2006) | Oxidativer Stress und Neurodegeneration in Drosophila melanogaster. |
| Veleri, Shobi (2005) | Analysis of the light-entrainment pathways for the circadian clock of Drosophila melanogaster. |
| Dowejko, Albert (2004) | Histologische und genetische Untersuchungen zur Funktion von headcase im visuellen System von Drosophila melanogaster. |
| Kiermayer, Claudia (2003) | Molekulare und funktionelle Charakterisierung der Neurodegeneration in der RasGAP (vap) Mutante in Drosophila melanogaster. |
| Stempfl, Thomas (2002) | Ein genetischer Screen zur Isolierung und Charakterisierung circadian regulierter Gene aus Drosophila melanogaster. |
| Walch, Heiko (2001) | Molekulare und histologische Charakterisierung der Neurodegenerationsmutante Vam in Drosophila melanogaster. |
| Mühlig-Versen, Maximilian (2001) | Histologische und funktionelle Untersuchung des swiss-cheese-Proteins und seines Orthologs aus Vertebraten in transgenen Drosophila melanogaster. |
| Fischer, Susanne (2001) | Untersuchungen zur Funktion der Ubiquitin spezifischen Protease nonstop im visuellen System von Drosophila melanogaster. |
| Täuber, Marcus (2000) | Funktionelle Charakterisierung des Neuropeptides PDF für das circadiane Verhalten von Drosophila melanogaster. |
| Maier, Dieter (2000) | Untersuchungen zu Genetik und Molekularbiologie der Entwicklung des visuellen Systems in Drosophila melanogaster. |
| Pollack, Inken (1995) | Untersuchung zur Funktion extrazellulärer Proteine im visuellen System von Drosophila melanogaster. |
| Kerscher, Stefan (1994) | Von einer Enhancer-trap Linie mit spezifischer Expression in den Riesenneuronen der Lobulaplatte zum Gen für ein Glycoprotein-prozessierendes Enzym. Molekulare und genetische Analyse des mas-1(mannosidase 1) Gens von Drosophila melanogaster. |
| Brunner, Alexandra (1994) | Die Funktion des Gens giant lens (gil) in der Entwicklung des visuellen Systems von Drosophila melanogaster. |
Diplom-/Masterarbeiten
Diplomarbeiten, Master Theses
| Peschke Marco (2020) | Functional analysis of the GABAA receptor subunits and their role in the VAM phenotype |
| Dlugos Sophia (2020 | Establishment of an anti-Snoo antiserum by recombinant protein expression |
| Hartmann Finn (2019) | Development and characterization of new genomic models to study the function of Park9 in Drosophila melanogaster |
| Pable Julia (2019) | Identification of putative Snoo interacting molecules in Drosophila melanogaster |
| Hummel Ursula (2018) | Charakterisierung des Onkogens snoo (ski-related novel oncogene) |
| Oestreich Svenja (2018) | Analysis of the Fuss protein complex and its molecular role in sensory neurons |
| Gizler Laura (2018) | Analysis of the Hedgehog pathway function in the adult Drosophila nervous system |
| Gütter Severin (2017) | Identifikation direkter und indirekter Zielgene des Fussel-Transkriptionsfaktorkomplexes |
| Arnold Martin (2016) | Neuronal Zn2+ Homeostasis in a Drosophila model of Kufor-Rakeb Syndrome |
| Pohl Kathrin (2016) | Analysis of autophagy and zinc homeostasis in a Drosophila model of Kufor-Rakeb syndrome |
| Schramm Matthias (2016) | Funktionelle Analyse der Smad4-Bindedomäne des Fussel-Proteins in Drosophila melanogaster und Erzeugung neuer gene und protein-traps am fussel Locus mit Hilfe von Mi(MIC)-Linien |
| Maier Konstantin (2016) | Etablierung eines ChIP-Seq Protokolls in Schneider Zellen (S2R+) |
| Skiba Marco (2015) | Molekulare und genetische Analyse verschiedener RNAi-dfussel-Linien in Drosophila melanogaster |
| Ilic Ivana (2015) | The effects of Fussel misexpression in glia cells of Drosophila melanogaster |
| Haba-Schneider Diana (2015) | Molecular characterization of the Vam mutation in Drosophila melanogaster |
| Wittmann Theresa (2015) | Phenotypical and electrophysiological analysis of the GABA receptor subunit LCCH3 G304D mutation in Drosophila melanogaster |
| Dirscherl Petra (2014) | Functional analysis of alternative transcripts of the Drosophila Parkinson related gene CG32000 |
| Irlbeck Christoph (2014) | Identification of fussel-regulated genes by RNA-Seq |
| Kullmann Lars (2014) | Analysis of the Fuss-dependent chromatin associated transcriptional regulation in Drosophila melanogaster |
| Wöster Ulrike (2014) | Engineering the fuss-locus in Drosophila melanogaster using the CRISPR/Cas9 technology |
| Edenharter Oliver (2013) | Study of the mitochondrial Dynamics in a Drosophila model of Friedreich’s ataxia |
| Feiler Christina (2013) | Unraveling the relationship between JNK signaling pathway and CINDR in Drosophila melanogaster |
| Fiesel Petra (2013) | Ectopic expression and phenotypic analysis of PD-associated human ATP13A2 and its putative orthologue dPARK9-H in Drosophila |
| Pimentel Vanessa (2013) | Effects of dfussel misexpression in the developing nervous system of Drosophila melanogaster |
| Zahn Malena (2013) | Studien zur Funktion der regulatorischen Region zwischen den Genen fuss und toy |
| Blumenstock Sonja (2012) | Neurodegeneration and Autophagy in a park9 Parkinson model in Drosophila melanogaster |
| Hochapfel, Florian (2012) | Study of the Mitrochondrial Dynamics in a Drosophila model of Parkinson's disease |
| Schilling, Tabea (2011) | A Drosophila melanogaster model of ALS. Effects of Dynactin-1G59S overexpression |
| Münch, Kristina (2011) | Funktionelle Analyse von RasGAP in Drosophila melanogaster |
| Harant, Eva-Maria (2011) | Identifizierung neuer Interaktionspartner des Fussel-Proteins in Drosophila melanogaster |
| Rauenbusch, Eva-Maria (2011) | Funktionelle Charakterisierung transgener Dynaktin p150Glued Stämme in Drosophila melanogaster: Ein Modell zur Analyse der Amyotrophen Lateralsklerose (ALS) |
| Rötzer, Vera (2010) | Untersuchungen zur Funktion der PI3Kinase/TOR-Signalwegs und der Autophagie in der vap Mutante |
| Heßner, Sabina (2010) | Untersuchungen zur Proteinexpression von Fussel in Drosophila melanogaster |
| Zhang, Li (2010) | Mitochondrial dysfunction in a Drosophila model of Parkinson's disease |
| Baumgartner, Markus (2010) | Analyse der Gen- und Proteinexpression des Functional Smad Suppressing Elements Fussel in Drosophila melanogaster |
| Hänel, Petra (2010) | Der Einfluss von Autophagie und oxidativem Stress auf die Degradation von α-Synuclein in Drosophila melanogaster |
| Bleyl, Cornelia (2008) | Untersuchungen zum Expressionsmuster von Rhodopsin 7 |
| Härtinger, Tobias (2008) | Expression, Aggregation und Toxizität von Syn-T in Drosophila melanogaster |
| Reif, Sebastian (2008) | Drosophila-RasGAP als negativer Regulator der Autophagie |
| Herrnberger, Leonie (2008) | Drosophila melanogaster as a model to study Best disease and age-related macular degeneration: First steps |
| Grismayer, Bettina (2008) | Genetische Interaktionen des Frataxingens in Drosophila melanogaster |
| Arnold, Cosmas (2008) | Die Rolle des PI3K/TOR-Signalwegs und der Makroautophagie für die Stabilität der Neuronen von Drosophila melanogaster |
| Stribl, Carola (2008) | Ein Drosophila melanogaster Modell für Amyotrophe Lateralsklerose (ALS) |
| Kalteis, Nina (2008) | Untersuchungen zur Funktion des PI3Kinase/TOR-Signalwegs in der vap-Mutante |
| Gmeiner, Florian (2008) | Intrazellulärer Abbau von α-Synuclein und dessen Einfluss auf die Neurodegeneration in Drosophila melanogaster |
| Scheckel, Claudia (2007) | Studying protein interactions of Frataxin in Drosophila melanogaster |
| Polzer, Harald (2007) | RNA-Interferenz-Untersuchungen an den white und scarlet Genen in Drosophila |
| Lapperger, Doris (2007) | Funktionelle Untersuchungen zum Atg8a-Gen in Drosophila melanogaster |
| Spitzauer, Verena (2007) | Molekulare und funktionelle Untersuchungen am white- und scarlet-Gen von Drosophila melanogaster |
| Ohmann, Elisabeth (2006) | Analyse von ABC Transporter-Genen in Drosophila melanogaster |
| Ruckerbauer, Sabine (2006) | Ein Hefe 2-Hybrid Screen mit dem Drosophila GABARAP Protein |
| Kastenberger, Michael (2006) | Molekulare und histologische Analyse der Vam-Mutation in Drosophila melanogaster |
| Daller, Barbara (2005) | Molekulare und funktionelle Untersuchungen der ABCG-Transporter scarlet und white in Drosophila melanogaster |
| Grießl, Sybille (2005) | Drosophila melanogaster als Modellorganismus für die Parkinsonerkrankung: Untersuchung zur Bedeutung von oxidativem Stress und der Proteasomenfunktion |
| Waltenspiel, Bernhard (2005) | Identifizierung und Charakterisierung photorezeptorspezifischer Antigene in Drosophila melanogaster |
| Bertl, Agnes (2005) | Untersuchungen zur Biologie von Parasiten in Drosophila melanogaster |
| Albrecht, Julia (2005) | Molekulare und funktionelle Untersuchungen der scarlet Mutante in Drosophila melanogaster |
| Simonavicius, Nicole (2005) | Molekulare und genetische Analyse der Drosophila GABARAP Mutante |
| Schneider, Ulrike (2005) | Charakterisierung der Carbonylreduktasen CG7322 und CG11200 in Drosophila melanogaster |
| Bayersdorfer, Florian (2005) | Untersuchungen zur Degeneration von dopaminergen Neuronen im Gehirn von Drosophila melanogaster |
| Wällisch, Johannes (2005) | Erstellen und Optimieren eines Kursprogrammes für das "Regensburger Experimentierlabor" |
| Mark, Michaela (2005) | Entwicklung eines Two-Hybrid-Systems in Hefe für das Drosophila vap-Gen |
| Pielnhofer, Susanne (2004) | Untersuchungen zum oxidativen Stress in Drosophila Schneider 2 Zellen |
| Bauer, Asli (2003) | Molekulare Analyse einer neuen brain tumor (brat) - Mutante in Drosophila melanogaster |
| Arndt, Stephanie (2003) | ATP-Binding Cassette (ABC)-Transporter in Drosophila melanogaster |
| Mügschl, Monika (2003) | Molekulare und histologische Charakterisierung "synaptischer" Gene in der Drosophila Neurodegenerationsmutante vap |
| Dorner, Liane (2003) | Ein genetischer Screen zur Identifizierung neuer Neurodegenerationsmutanten in Drosophila melanogaster |
| Landskron, Johannes (2002) | Ein genetischer Screen zur Erzeugung von Mutanten in circadian regulierten Genen aus Drosophila melanogaster |
| Giesecke, Astrid (2002) | Molekulare und funktionelle Analyse der Neurodegenerationsmutante vap in Drosophila melanogaster |
| Glaser, Franz (2002) | Genetische und molekulare Untersuchung zur circadianen Thermorezeption in Drosophila melanogaster |
| Gruenewald, Christoph (2002) | Bedeutung von oxidativem Stress für die Neurodegenerationsmutante sniffer in Drosophila melanogaster |
| Beibl, Jeanette (2002) | Expression von Cryptochrom und Rhodopsin7 in Drosophila-Zellkulturen |
| ElChartouney, Carol (2002) | A Yeast Two-Hybrid Screen with a Putative Myosin Binding Subunit of Drosophila melanogaster |
| Bauer, Richard (2002) | Funktionelle Charakterisierung des Gens der Myosinphosphatase in Drosophila melanogaster |
| Möhle, Christoph (2001) | Molekulare und genetische Analyse des sniffer Gens in Drosophila melanogaster |
| Elling, Ullrich (2001) | Molekulare und Funktionelle Analyse von Myosinphosphatase in Drosophila melanogaster |
| Wisotzki, Barbara (2001) | Extraretinale Photorezeptoren und ihr Einfluß auf die circadiane Rhythmik von Drosophila melanogaster |
| Berger, Birgit (2000) | Molekulare und genetische Analyse der Linie 1077/01 (querkopf) von Drosophila melanogaster |
| Gehrmann, Mathias (1999) | Die Rolle von double-time bei der Zielfindung von Axonen im visuellen System von Drosophila melanogaster |
| Kiermayer, Claudia (1999) | Genetische und molekulare Analyse einer Ras-GAP Neurodegenerationsmutante in Drosophila melanogaster |
| Sulzbacher, Sabine (1999) | Analyse einer p120 Ras Gap-Mutante in Drosophila melanogaster |
| Maruhn, Sinje (1999) | Charakterisierung der tres-cDNA aus der Vam-Region und Kartierung des Vam-Gens von Drosophila melanogaster |
| Hammerschmied, Christine (1999) | Weiterführende Charakterisierung der Neurodegenerationsmutante löchrig (loe) in Drosophila melanogaster |
| Adelberger, Georg (1999) | Analyse neuer Mutanten in der Entwicklung des visuellen Systems von Drosophila melanogaster |
| Springer, Wolfdieter (1999) | Molekulare und genetische Analyse der axonalen Pathfindingmutanten 961-08 und 1480-11 im visuellen System von Drosophila melanogaster |
| Tschäpe, Jakob-Andreas (1998) | Molekulare und genetische Analyse von löchrig (loe) - einer neuen Neurodegenerationsmutante in Drosophila melanogaster |
| Cruz, Alexandre Bettencourt da (1998) | Molekulare und genetische Analyse der Vam-Mutation in Drosophila melanogaster |
| Barth, Nicole (1998) | Molekulare und genetische Analyse der Linien 194-18 und 915-10 bei Drosophila melanogaster |
| Fischer, Susanne (1998) | Molekulare und genetische Analyse axonaler Pathfindingmutanten im visuellen System bei Drosophila melanogaster |
| Vogel, Marion (1998) | Molekulare und funktionelle Charakterisierung der mitochondrialen single-stranded DNA binding (mtssB) Protein Mutante low power1 (lopo1) bei Drosophila melanogaster |
| Dütsch, Gabriele (1998) | Molekulare und funktionelle Charakterisierung des pdf-Gens von Drosophila melanogaster |
| Stempfl, Thomas (1998) | Klonierung und molekulare Charakterisierung des swiss cheese (sws)-Homologs aus der Maus |
| Schymeinsky, Jürgen (1998) | Molekulare und genetische Charakterisierung der quo (quo vadis)-Region bei Drosophila melanogaster |
| Schleip, Ingeborg (1997) | Molekulare und genetische Analyse der Vam-Region in Drosophila melanogaster |
| Koch, Ingolf (1997) | Charakterisierung von Pathfinding-Mutanten bei Drosophila melanogaster |
| Speth, Thomas (1997) | Genetische und histologische Untersuchungen zur Entwicklung des visuellen Systems bei Drosophila melanogaster |
| Mühlig-Versen, Max (1997) | Molekulare und funktionelle Untersuchung zur circadianen Rhythmik in Drosophila melanogaster |
| Walch, Heiko (1996) | Strategien und experimentelle Ansätze zur Klonierung des pdf-Gens in Drosophila melanogaster |
| Glück, Thomas (1996) | Genetische und molekulare Charakterisierung des Vam-Genlokus von Drosophila melanogaster |
| Maier, Dieter (1996) | Die Funktion der Gene tenascin (ten) und giant lens (gil) in der Entwicklung des visuellen Systems von Drosophila melanogaster |
Bachelorarbeiten
Bachelorarbeiten
| Kerstin Wullinger (2021) |
|
| Forster Maximilian (2020) |
|
| Maskos Stephanie (2020) |
|
| Spiekers Janek (2020) |
|
| Hinkelmann Angelika (2020) |
|
| Jung Nina (2019) |
|
| Süß Lena-Marie (2019) |
|
| Jackermaier Veronika (2019) |
|
| Nielsen Jana (2019) |
|
| Bach Richard (2019) |
|
| Kurtanovic Alisa (2019) |
|
| Pervan Philipp (2019) |
|
| Horsch Anna-Lena (2019) |
|
| Berger Andreas (2019) |
|
| Loesch Andreas (2019) |
|
| Stich Danica (2018) |
|
| Igl Markus (2018) |
|
| Hübner Thomas (2018) |
|
| Baumgartl Conradin (2018) |
|
| Polat Sefkan (2018) |
|
| Paulus Nina (2017) |
|
| Wagner Patrick (2017) |
|
| Wünsche Julia (2017) |
|
| Clement Janika (2017) |
|
| Zylka Martha (2016) |
|
| Greil Stefanie (2016) |
|
| Zaglauer Sabrina (2016) |
|
| Russow Diana (2016) |
|
| Gizler Laura (2015) |
|
| Dittrich Daniel (2015) |
|
| Röhrl Ramona (2015) |
|
| Ecker Christina (2014) |
|
| Polz Jan (2014) |
|
| Reinig Jeanette (2014) |
|
| Sauerer Tanja (2014) |
|
| Sitka Elisabeth (2014) |
|
| Dendorfer Anne-Sarah (2013) |
|
| Pfaff Christina (2013) |
|
| Schmid Sophia (2013) |
|
| Draxinger Daniel (2012) |
|
| Fendl Sandra (2012) |
|
| Iglhaut (2012) |
|
| Jobst Belinda (2012) |
|
| Maierhofer Anna (2012) |
|
| Ponkratz Christine (2012) |
|
| Schmidt Christina (2012) |
|
| Weichselgartner Tobias (2012) |
|
| Gruber Raphaela (2011) |
|
| Habinghorst Katrin (2011) |
|
| Jaschkowitz Lena (2011) |
|
| Meier Elisabeth (2011) |
|
| Schneider Evelyn (2011) | Studien zur Interaktion zwischen Fussel, Mad und Medea in S2-Zellen und Drosophila melanogaster |
| Voggenreiter Lisa (2011) | Analyse mitochondrieller Effekte ausgelöst durch Park9 Reduktion |
| Anders Ines (2010) |
|
| Edenharter Oliver (2010) |
|
| Pfab Alexander (2010) |
|
| Schneider Daniela (2010) |
|
| Tremmel Sarah (2010) |
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| Weber Nina-Maria (2010) |
|
| Zahn Malena (2010) |
|
| Kapustij Simon (2009) |
|
| Klatt Martina (2009) |
|
| Wamack Margarete (2009) |
|
Staatsexamen
Zulassungsarbeiten
| Schmittlein Carina (2013) | Klonierung und Analyse von drei Überexpressionskonstrukten: dfusselBkC, dfussel BkC-GFP und dfusselBk-GFP |
| Schmiel, Sabrina (2002) | Untersuchung über die Neurodegenerationsmutante sniffer und die Auswirkungen von Sauerstoffstress am Modellorganismus Drosophila melanogaster |
| Merkel, Oliver (2001) | Fremdexpression des Drosophila-UBL3 Gens in E. coli und Isolierung seiner cDNA |
| Rebentrost, Inken (1999) | Der Einfluß des Neuropeptids PDF auf die circadiane Rhythmik von Drosophila melanogaster |
| Rommel, Susanne (1997) | Entwicklungsgenetik des visuellen Systems von Drosophila melanogaster: Spezifische Genexpression in den optischen Loben |
Stefan Buchhauser - 18.02.2021 10:32 