Publications

Latest publications

Interested visitors of our website can find our latest publications here.

For more information, please refer to Prof. Zieglers ORCID: 0000-0003-3439-7213 on https://orcid.org/0000-0003-3439-7213.

Bhatt M, Gauthier-Manuel L, Lazzarin E, Zerlotti R, Ziegler C, Bazzone A, Stockner T, Bossi E. A comparative review on the well-studied GAT1 and the understudied BGT-1 in the brain.                                                                                                           Front Physiol. 14:1145973. doi: 10.3389/fphys.2023.1145973 (2023).
 
Leone V, Bradshaw RT, Koshy C, Suhwan Lee P, Fenollar-Ferrer C, Heinz V, Ziegler C, Forrest LR. Insights into autoregulation of a membrane protein complex by its cytoplasmic domains.                                                                                         Biophys J. 122(3):577-594. doi: 10.1016/j.bpj.2022.12.021 (2023).
 
Tantirimudalige S, Buckley TSC, Chandramohan A, Richter RM, Ziegler C, Anand GS. Hyperosmotic Stress Allosterically Reconfigures Betaine Binding Pocket in BetP.            J Mol Biol. 434(17):167747. doi: 10.1016/j.jmb.2022.167747 (2022).
 
Peter MF, Ruland JA, Depping P, Schneberger N, Severi E, Moecking J, Gatterdam K, Tindall S, Durand A, Heinz V, Siebrasse JP, Koenig PA, Geyer M, Ziegler C, Kubitscheck U, Thomas GH, Hagelueken G. Structural and mechanistic analysis of a tripartite ATP-independent periplasmic TRAP transporter.                                                               Nat Commun. 13(1):4471. doi: 10.1038/s41467-022-31907-y (2022).

Wopperer FJ, Knaup KX, Stanzick KJ, Schneider K, Jobst-Schwan T, Ekici AB, Uebe S, Wenzel A, Schliep S, Schürfeld C, Seitz R, Bernhardt W, Gödel M, Wiesener A, Popp B, Stark KJ, Gröne HJ, Friedrich B, Weiß M, Basic-Jukic N, Schiffer M, Schröppel B, Huettel B, Beck BB; Genomics England Research Consortium; Sayer JA, Ziegler C, Büttner-Herold M, Amann K, Heid IM, Reis A, Pasutto F, Wiesener MS. Diverse molecular causes of unsolved autosomal dominant tubulointerstitial kidney diseases.                    Kidney Int. 102(2):405-420. doi: 10.1016/j.kint.2022.04.031 (2022).
 
Heinz V*, Jäckel W*, Kaltwasser S*, Cutugno L, Bedrunka P, Graf A, Reder A, Michalik S, Dhople VM, Madej MG, Conway M, Lechner M, Riedel K, Bange G, Boyd A, Völker U, Lewis RJ, Marles-Wright J, Ziegler C, Pané-Farré J. The Vibrio vulnificus stressosome is an oxygen-sensor involved in regulating iron metabolism.                               Commun Biol. 5(1):622. doi: 10.1038/s42003-022-03548-w (2022).
 
Miksys A*, Fu L*, Madej MG*, Guerreiro DN, Kaltwasser S, Conway M, Ejder S, Bruckmann A, Marles-Wright J, Lewis RJ, O'Byrne C, Pané-Farré J, Ziegler C. Molecular insights into intra-complex signal transmission during stressosome activation. Commun Biol. 5(1):621. doi: 10.1038/s42003-022-03549-9 (2022).
 
Issler N, Afonso S, Weissman I, Jordan K, Cebrian-Serrano A, Meindl K, Dahlke E, Tziridis K, Yan G, Robles-López JM, Tabernero L, Patel V, Kesselheim A, Klootwijk ED, Stanescu HC, Dumitriu S, Iancu D, Tekman M, Mozere M, Jaureguiberry G, Outtandy P, Russell C, Forst AL, Sterner C, Heinl ES, Othmen H, Tegtmeier I, Reichold M, Schiessl IM, Limm K, Oefner P, Witzgall R, Fu L, Theilig F, Schilling A, Shuster Biton E, Kalfon L, Fedida A, Arnon-Sheleg E, Ben Izhak O, Magen D, Anikster Y, Schulze H, Ziegler C, Lowe M, Davies B, Böckenhauer D, Kleta R, Falik Zaccai TC, Warth R. A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness.                               J Am Soc Nephrol. 33(4):732-745. doi: 10.1681/ASN.2021101312 (2022).
 
Parkinson EK, Adamski J, Zahn G, Gaumann A, Flores-Borja F, Ziegler C, Mycielska ME. Extracellular citrate and metabolic adaptations of cancer cells.                            Cancer Metastasis Rev. 40(4):1073-1091. doi: 10.1007/s10555-021-10007-1 (2021).
 
Grosch M, Brunner K, Ilyaskin AV, Schober M, Staudner T, Schmied D, Stumpp T, Schmidt KN, Madej MG, Pessoa TD, Othmen H, Kubitza M, Osten L, de Vries U, Mair MM, Somlo S, Moser M, Kunzelmann K, Ziegler C, Haerteis S, Korbmacher C, Witzgall R. A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts.                                                                 J Cell Sci. 134(16):jcs259013. doi: 10.1242/jcs.259013 (2021).
 
Drexler K, Schmidt KM, Jordan K, Federlin M, Milenkovic VM, Liebisch G, Artati A, Schmidl C, Madej MG, Tokarz J, Cecil A, Jagla W, Haerteis S, Aung T, Wagner C, Kolodziejczyk M, Heinke S, Stanton EH, Schwertner B, Riegel D, Wetzel CH, Buchalla W, Proescholdt M, Klein CA, Berneburg M, Schlitt HJ, Brabletz T, Ziegler C, Parkinson EK, Gaumann A, Geissler EK, Adamski J, Haferkamp S, Mycielska ME. Cancer-associated cells release citrate to support tumour metastatic progression.                                 Life Sci Alliance. 4(6):e202000903. doi: 10.26508/lsa.202000903 (2021).
 
Grünberger F, Reichelt R, Waege I, Ned V, Bronner K, Kaljanac M, Weber N, El Ahmad Z, Knauss L, Madej MG, Ziegler C, Grohmann D, Hausner W. CopR, a Global Regulator of Transcription to Maintain Copper Homeostasis in Pyrococcus furiosus.                  Front Microbiol. 11:613532. doi: 10.3389/fmicb.2020.613532 (2021).
 
Hartmann AM, Fu L, Ziegler C, Winklhofer M, Nothwang HG. Structural changes in the extracellular loop 2 of the murine KCC2 potassium chloride cotransporter modulate ion transport.                                                                                                                J Biol Chem. 296:100793. doi: 10.1016/j.jbc.2021.100793 (2021).
 
Errasti-Murugarren E, Fort J, Bartoccioni P, Díaz L, Pardon E, Carpena X,
Espino-Guarch M, Zorzano A, Ziegler C, Steyaert J, Fernández-Recio J, Fita I,
Palacín M. L amino acid transporter structure and molecular bases for the
asymmetry of substrate interaction.
Nat Commun. 18;10(1):1807. doi: 10.1038/s41467-019-09837-z (2019).
 
Leone V, Waclawska I, Kossmann K, Koshy C, Sharma M, Prisner TF, Ziegler
C, Endeward B, Forrest LR. Interpretation of spectroscopic data using molecular simulations for the secondary active transporter BetP.
J Gen Physiol. 151(3):381-394. doi: 10.1085/jgp.201812111 (2019).
 
Allolio C, Magarkar A, Jurkiewicz P, Baxová K, Javanainen M, Mason PE,
Šachl R, Cebecauer M, Hof M, Horinek D, Heinz V, Rachel R, Ziegler CM,
Schröfel A, Jungwirth P. Arginine-rich cell-penetrating peptides induce
membrane multilamellarity and subsequently enter via formation of a fusion
pore.
Proc Natl Acad Sci U S A. 115(47):11923-11928. doi:0.1073/pnas.1811520115 (2018).
 
Mycielska ME, Dettmer K, Rümmele P, Schmidt K, Prehn C, Milenkovic VM,
Jagla W, Madej GM, Lantow M, Schladt M, Cecil A, Koehl GE, Eggenhofer E,
Wachsmuth CJ, Ganapathy V, Schlitt HJ, Kunzelmann K, Ziegler C, Wetzel CH, Gaumann A, Lang SA, Adamski J, Oefner PJ, Geissler EK. Extracellular Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer Development In Vivo.
Cancer Res. 78(10):2513-2523. doi: 10.1158/0008-5472.CAN-17-2959 (2018).
 
Madej MG, Ziegler CM. Dawning of a new era in TRP channel structural
biology by cryo-electron microscopy.
Pflugers Arch. 470(2):213-225. doi: 10.1007/s00424-018-2107-2 (2018).
 
Ziegler C. Preface.
Methods Enzymol. 594:xi-xii. doi: 10.1016/S0076-6879(17)30277-X (2017).
 
Jazi AA, Ploetz E, Arizki M, Dhandayuthapani B, Waclawska I, Krämer R,
Ziegler C, Cordes T. Caging and Photoactivation in Single-Molecule Förster
Resonance Energy Transfer Experiments.
Biochemistry 56(14):2031-2041. doi: 10.1021/acs.biochem.6b00916 (2017).

Wilkes M, Madej MG, Kreuter L, Rhinow D, Heinz V, De Sanctis S, Ruppel S,
Richter RM, Joos F, Grieben M, Pike AC, Huiskonen JT, Carpenter EP, Kühlbrandt W, Witzgall R, Ziegler C. Molecular insights into lipid-assisted Ca²⁺ regulation of the TRP channel Polycystin-2.
Nat Struct Mol Biol. 24(2):123-130. doi: 10.1038/nsmb.3357 (2017).