Publications
Publications
(58) Schueler J, Kuenzel J, Thuesing A, Pion E, Behncke RY, Haegerling R, Fuchs D, Kraus A, Buchholz B, Huang B, Merhof D, Werner JM, Schmidt KM, Hackel C, Aung T, Härteis S. Ultra high frequency ultrasound enables real-time visualization of blood supply from chorioallantoic membrane to human autosomal dominant polycystic kidney tissue. Sci Rep 14, 10063 (2024). doi.org/10.1038/s41598-024-60783-3
(57) Dorn A, Neff S, Hupp S, Engelhardt M, Pion E, Lenze U, Knebel C, Duprée A, Schewe S, Weber M, Wulbrand C, Hillmann A, Clarke P, Kainz P, Aung T and Haerteis S, Analysis of Osteosarcoma Cell Lines and Patient Tissue Using a 3D In Vivo Tumor Model - Possible Effects of Punicalagin, Organoids, accepted.
(56) Ettner-Sitter A, Montagner A, Kuenzel J, Brackmann K, Schäfer M, Schober R, Weber F, Aung T, Hackl C, Haerteis S. Visualization of vascular perfusion of human pancreatic cancer tissue in the CAM model and its impact on future personalized drug testing. Organoids accepted.
(55) Treeck O, Haerteis S, Ortmann O. Non-Coding RNAs Modulating Estrogen Signaling and Response to Endocrine Therapy in Breast Cancer. Cancers (Basel). 2023 Mar 7;15(6):1632. doi: 10.3390/cancers15061632. PMID: 36980520
(54) Oliinyk D, Eigenberger A, Felthaus O, Haerteis S, Prantl L. Chorioallantoic Membrane Assay at the Cross-Roads of Adipose-Tissue-Derived Stem Cell Research
Cells 2023, 12, 592. doi.org/10.3390/cells12040592.
(53) Waltera A, Schulz D, Schaefer N, Stoeckl S, Pion E, Haerteis S, Reichert TE, Ettl T, Bauer RJ. Opposing MMP-9 Expression in Mesenchymal Stromal Cells and Head and Neck Tumor Cells after Direct 2D and 3D Co-Culture. Int J Mol Sci. 2023 Jan 9;24(2):1293.
(52) Pandamooz S, Jurek B, Dianatpour M, Haerteis S, Limm K, Oefner PJ, Dargahi L, Borhani-Haghighi A, Miyan JA, Salehi MS. The beneficial effects of chick embryo extract preconditioning on hair follicle stem cells: A promising strategy to generate Schwann cells. Cell Prolif. 2023 Jan 11:e13397. doi: 10.1111/cpr.13397.
(51) Mahl L, Ollig J, Schweihofer V, Wiegand L, Torkler P, Haerteis S, Aung T. Importance and implications of exosomes in nephrology and urology. Pflugers Arch. 2022 Nov 18. doi: 10.1007/s00424-022-02771-y.
(50) Benjamin Jurek, Lucia Denk, Nicole Schäfer, Mohammad Saied Salehi, Sareh Pandamoo5, Silke Haerteis. Oxytocin accelerates tight junction formation and impairs cellular migration in 3D spheroids: Evidence from Gapmer-induced exon skipping. Front Cell Neurosci. 2022 Oct 3;16:1000538. doi: 10.3389/fncel.2022.1000538.
(49) Sommerauer L, Phyo A, Pion E, Zucal I, Klingelhoefer E, Thu S, Win T, Khin S, Kyaw T, Zaw HH, Htwe MM, Fabbri N, Haerteis S, Aung T. Modified Borggreve-Van Nes-Winkelmann rotationplasty for surgery in developing countries. BMC Surg. 2022 Sep 7;22(1):333. doi: 10.1186/s12893-022-01780-z. PMID: 36071411.
(48) Eigenberger A, Felthaus O, Schratzenstaller T, Haerteis S, Utpatel K, Prantl L. The Effects of Shear Force-Based Processing of Lipoaspirates on White Adipose Tissue and the Differentiation Potential of Adipose Derived Stem Cells. Cells. 2022 Aug 16;11(16):2543. doi: 10.3390/cells11162543. PMID: 36010620 Free PMC article.
(47) Mena Kuri P, Pion E, Mahl L, Kainz P, Schwarz S, Brochhausen C, Aung Th, Haerteis S (2022). Deep Learning-Based Image Analysis for the Quantification of Tumor-Induced Angiogenesis in the 3D In Vivo Tumor Model - Establishment and Addition to Laser Speckle Contrast Imaging (LSCI). Cells, 11(15), 2321. doi.org/10.3390/cells11152321.
(46) Pion E, Kanovsky J, Boscheck S, Wagner B, Schmidt KM, Brunner SM, Schlitt HJ, Aung T, Hackl C, Haerteis S. 3D in vivo models for translational research on pancreatic cancer: the chorioallantoic membrane (CAM) model. Cancers accepted 28 July 2022.
(45) Bichlmayer EM, Mahl L, Hesse L, Pion E, Haller V, Moehwald A, Hackl C, Werner J, Schlitt HJ, Schwarz S, Kainz P, Brochhausen C, Groeger C, Steger F, Koelbl O, Daniel C, Amann K, Kraus A, Buchholz B, Aung T, Haerteis S (2022). 3D-in vivo-model to study human renal cystic tissue and mouse kidney slices.
Cells, 11, 2269. doi.org/10.3390/cells11152269.
(44) Drexler K, Schwertner B, Haerteis S, Aung T, Berneburg M, Geissler EK, Mycielska ME and Haferkamp S. The Role of Citrate Homeostasis in Merkel Cell. Carcinoma Pathogenesis. Cancers 2022, 14, 3425.
(43) Kohl C, Aung T, Haerteis S, Ignatov A, Ortmann O, Papathemelis T. The 3D in vivo chorioallantoic membrane model and its role in breast cancer research. Journal of Cancer Research and Clinical Oncology. Cancer Res Clin Oncol. 2022 Feb 5.
(42) Artunc F, Bohnert BN, Schneider JC, Staudner T, Sure F, Ilyaskin AV, Wörn M, Essigke D, Janessa A, Nielsen NV, Birkenfeld AL, Etscheid M, Haerteis S, Korbmacher C, Kanse SM. Proteolytic activation of the epithelial sodium channel (ENaC) by factor VII activating protease (FSAP) and its relevance for sodium retention in nephrotic mice. Pflugers Arch. 2021 Dec 6. doi: 10.1007/s00424-021-02639-7.
(41) Zucal I, Geis S, Prantl L, Haerteis S, Aung T. Indocyanine Green for Leakage Control in Isolated Limb Perfusion. J Pers Med. 2021 Nov 5;11(11):1152. doi: 10.3390/jpm11111152.
(40) Kohl C, Aung T, Haerteis S, Papathemelis T. Clin Hemorheol Microcirc. Assessment of breast cancer primary tumor material in a 3D in vivo model. 2021 Aug 28. doi: 10.3233/CH-219113.
(39) Grosch M, Brunner K, Ilyaskin AV, Schober M, Staudner T, Schmied D, Stumpp T, Schmidt KN, Madej MG, Pessoa TD, Othmen H, Kubitza M, Osten L, de Vries U, Mair MM, Somlo S, Moser M, Kunzelmann K, Ziegler C, Haerteis S, Korbmacher C, Witzgall R. J Cell Sci. A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts. 2021 Aug 15;134(16): jcs259013. doi: 10.1242/jcs.259013. Epub 2021 Aug 23. PMID: 34345895.
(38) Drexler K, Schmidt KM, Jordan K, Federlin M, Milenkovic VM, Liebisch G, Artati A, Schmidl C, Madej G, Tokarz J, Cecil A, Jagla W, Haerteis S, Aung T, Wagner C, Kolodziejczyk M, Heinke S, Stanton EH, Schwertner B, Riegel D, Wetzel CH, Buchalla W, Proescholdt M, Klein CA, Berneburg M, Schlitt HJ, Brabletz T, Ziegler C, Parkinson EK, Gaumann A, Geissler EK, Adamski J, Haferkamp S, Mycielska ME. Cancer-associated cells release citrate to support tumour metastatic progression. Life Sci Alliance. 2021 Mar 23;4(6):e202000903. doi: 10.26508/lsa.202000903. Print 2021 Jun. PMID: 33758075.
(37) Zucal I, Feder AL, Kyaw T, Khin S, Heidekrueger P, Prantl L, Haerteis S, Aung T An innovative simulation model for microvascular training Plastic and Reconstructive Surgery accepted for publication.
(36) Pion E, Zucal I, Troebs J, Feder AL, Kyaw T, Khin S, Heidekrueger PI, Prantl L, Haerteis S, Aung T New, Innovative 3D-in-vivo-Model for High-level Microsurgical and Supramicrosurgical Training - A Replacement for Animal Models Plastic and Reconstructive Surgery accepted for publication.
(35) Pion E, Asam C, Feder AL, Felthaus O, Heidekrueger PI, Prantl L, Haerteis S, Aung T. Laser speckle contrast analysis (LASCA) technology for the semiquantitative measurement of angiogenesis in in-ovo-tumor-model. Microvasc Res. 2020 Sep 16:104072. doi: 10.1016/j.mvr2020.1040722.
(34) Troebs J, Asam C, Pion E, Prantl L, Aung T, Haerteis S. 3D monitoring of tumor volume in an in vivo model. Clin Hemorheol Microcirc. 2020 Sep 8. doi: 10.3233/CH2092166.
(33) Feder AL, Pion E, Troebs J, Lenze U, Prantl L, Htwe MM, Phyo A, Haerteis S, Aung T. Extended analysis of intratumoral heterogeneity of primary osteosarcoma tissue using 3D-in-vivo-tumor-model. Clin Hemorheol Microcirc. 2020 Sep 7. doi: 10.3233/CH2092044.
(32) Lamby P, Minkow A, Handt S, Falter J, Schellenberg EL, Graf S, Hiebl B, Haerteis S, Gemeinhardt O, Krüger-Genge A, Klosterhalfen B, Jung EM, Franke RP, Momeni A, Prantl L, Jung F. Histological and SEM Assessment of Blood Stasis in Kidney Blood Vessels after Repeated Intra-Arterial Application of Radiographic Contrast Media. Life (Basel). 2020 Aug 27;10(9):E167. doi: 10.3390/life10090167.
(31) Stolwijk JA, Sauer L, Ackermann K, Nassios A, Aung T, Haerteis S, Bäumner AJ, Wegener J, Schreml S. pH sensing in skin tumors: Methods to study the involvement of GPCRs, acid-sensing ion channels and transient receptor potential vanilloid channels. Exp Dermatol. 2020 Jul 13. doi: 10.1111/exd.14150.
(30) Prantl L, Eigenberger A, Gehmert S, Haerteis S, Aung T, Rachel R, Jung EM, Felthaus O. Enhanced Resorption of Liposomal Packed Vitamin C Monitored by Ultrasound. J Clin Med. 2020 May 26;9(6):E1616.
(29) Asam C, Buerger K, Felthaus O, Brebant V, Rachel R, Prantl L, Witzgall R, Haerteis S, Aung T. Subcellular localization of the chemotherapeutic agent doxorubicin in renal epithelial cells and in tumor cells using correlative light and electron microscopy. Clin Hemorheol Microcirc. 2019 Sep 18. doi: 10.3233/CH-199212.
(28) Aung T, Asam C, Haerteis S. Ion channels in sarcoma: pathophysiology and treat- ment options. Pflügers Archiv 2019 Sep; 471(9): 1163-1171. PDF
(27) Bohnert BN, Daiminger S, Wörn M, Sure F, Staudner T, Ilyaskin AV, Batbouta F, Janessa A, Schneider JC, Essigke D, Kanse S, Haerteis S, Korbmacher C, Artunc F. Urokinase‐type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)‐mediated sodium retention in experimental nephrotic syndrome. Acta Physiol (Oxf). 2019 Apr 21:e13286. PDF
(26) Ilyaskin AV, Sure F, Nesterov V, Haerteis S, Korbmacher C. Bile acids inhibit human purinergic receptor P2X4 in a heterologous expression system. J Gen Physiol. 2019 Apr 15. pii: jgp.201812291. PDF
(25) Haerteis S, Schork A, Dörffel T, Bohnert BN, Nacken R, Wörn M, Xiao M, Essigke D, Janessa A, Schmaier AH, Feener E, Häring HU, Bertog M, Korbmacher C, and Artunc F (2018). Plasma kallikrein activates epithelial sodium channel (ENaC) in vitro, but is not essential for volume retention in nephrotic mice. Acta Physiol (Oxf). 2018 Sep; 224(1): e13060. PDF
(24) Ilyaskin AV, Kirsch SA, Böckmann RA, Sticht H, Korbmacher C, Haerteis S, Diakov A. The degenerin region of the human bile acid-sensitive ion channel (BASIC) is involved in channel inhibition by calcium and activation by bile acids. Pflügers Archiv 2018 Jul; 470(7): 1087-1102. PDF
(23) Bohnert BN, Menacher M, Janessa A, Wörn M, Schork A, Daiminger S, Kalbacher H, Häring HU, Daniel C, Amann K, Sure F, Bertog M, Haerteis S, Korbmacher C, Artunc F (2018). Aprotinin prevents proteolytic ENaC activation and volume retention in nephrotic syndrome. Kidney International 93, 159-172. PDF
(22) Sostegni S, Diakov A, McIntyre P, Bunnett N,, Korbmacher C, Haerteis S (2017). Erratum to: Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase. Pflügers Archiv 469, 845-846. PDF
(21) Ilyaskin A, Diakov A, Korbmacher C, Haerteis S (2017). Bile acids potentiate proton-activated currents in Xenopus laevis oocytes expressing human acid-sensing ion channel (ASIC1a). Physiol Rep 5 (3), e13132. PDF
(20) Ilyaskin A, Diakov A, Korbmacher C, Haerteis S (2016). Activation of the human epithelial sodium channel (ENaC) by bile acids involves the degenerin site. J Biol Chem 291,19835-19847. PDF
(19) Schork A, Woern M, Kalbacher H, Voelter W, Nacken R, Bertog M, Haerteis S, Korbmacher C, Heyne N, Peter A, Häring HU, Artunc F (2016). Association of plasminuria with overhydration in patients with CKD. Clin J Am Soc Nephrol 11, 761-769. PDF
(18) Jeggle P, Smith ES, Stewart AP, Haerteis S, Korbmacher C, Edwardson JM (2015). Atomic force microscopy imaging reveals the formation of ASIC/ENaC cross-clade ion channels. Biochem Biophys Res Commun 464, 38-44. PDF
(17) Zhao P, Lieu T, Barlow N, Sostegni S, Haerteis S, Korbmacher C, Liedtke W, Jimenez-Vargas NN, Vanner SJ, Bunnett NW (2015). Neutrophil elastase activates PAR2 and TRPV4 to cause inflammation and pain. J Biol Chem. 290, 13875-13887. PDF
(16) Sostegni S, Diakov A, McIntyre P, Bunnett NW, Korbmacher C, Haerteis S (2015). Sensitisation of TRPV4 by PAR₂ is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase. Pflügers Archiv 467, 687-701. PDF
(15) Haerteis S, Krappitz A, Krappitz M, Murphy JE, Bertog M, Krueger B, Nacken R, Chung H, Hollenberg MD, Knecht W, Bunnett NW, Korbmacher C (2014). Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites. J Biol Chem 289, 19067-19078. PDF
(14) Krappitz M, Korbmacher C, Haerteis S (2014). Demonstration of proteolytic activation of the epithelial sodium channel (ENaC) by combining current measurements with detection of cleavage fragments. J Vis Exp 5, 89. PDF
(13) Lieu T, Jayawerra G, Zhao P, Poole D, Jensen D, Grace M, McIntyre P, Bron R, Wilson YM, Krappitz M, Haerteis S, Korbmacher C, Steinhoff MS, Nassini R, Materazzi S, Geppetti P, Corvera CU, Bunnett NW (2014). The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice. Gastroenterology 147, 1417-28. PDF
(12) Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis N, Jensen D, Kocan M, Sostegni S, Haerteis S, Baraznenok V, Henderson I, Lindstrom E, Guerrero-Alba R, Valdez-Morales E, Liedtke W, McIntyre P, Vanner S, Korbmacher C, Bunnett NW (2014). Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.
J Biol Chem 289, 27215-34. PDF
(11) Lefèvre CMT, Diakov A, Haerteis S, Korbmacher C, Gründer S, Wiemuth D (2014). Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC). Pflügers Archiv 466, 253-63. PDF
(10) Rauh R, Soell D, Haerteis S, Diakov A, Nesterov V, Krueger B, Sticht H, Korbmacher C (2013). A mutation in the β-subunit of ENaC identified in a patient with cystic fibrosis-like symptoms has a gain-of-function effect. Am J Physiol Lung Cell Mol Physiol 304,L43-55. PDF
(9) Haerteis S, Krappitz M, Diakov A, Krappitz A, Rauh R, Korbmacher C (2012). Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ-subunit of the human epithelial sodium channel (ENaC). J Gen Physiol 140, 375-89. PDF
(8) Haerteis S, Krappitz M, Bertog M, Krappitz A, Baraznenok V, Henderson I, Lindström E, Murphy JE, Bunnett NW, Korbmacher C (2012). Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S. Pflügers Archiv 464, 353-65. PDF
(7) Haerteis S, Schaal D, Brauer F, Brüschke S, Schweimer K, Rauh R, Sticht H, Rösch P, Schwarzinger S, Korbmacher C (2012). An inhibitory peptide derived from the α-subunit of the epithelial sodium channel (ENaC) shows a helical conformation. Cell Physiol Biochem 29, 761-774. PDF
(6) Krueger B, Schlötzer-Schrehardt U, Haerteis S, Zenkel M, Chankiewitz VE, Amann KU, Kruse FE, Korbmacher C (2012). Four subunits (αβγδ) of the epithelial sodium channel (ENaC) are expressed in the human eye in various locations. Invest Ophthalmol Vis Sci 53, 596-604. PDF
(5) Stewart AP, Haerteis S, Diakov A, Korbmacher C, Edwardson JM (2011). Atomic force microscopy reveals the architecture of the epithelial sodium channel (ENaC). J Biol Chem 286, 31944-31952. PDF
(4) Huber R, Krueger B, Diakov A, Korbmacher J, Haerteis S, Einsiedel J, Gmeiner P, Azad AK, Cuppens H, Cassiman JJ, Korbmacher C, Rauh R (2010). Functional characterization of a partial loss-of-function mutation of the epithelial sodium channel (ENaC) associated with atypical cystic fibrosis. Cell Physiol Biochem 25, 145-158. PDF
(3) Haerteis S, Krueger B, Korbmacher C, Rauh R (2009). The δ-subunit of the epithelial sodium channel (ENaC) enhances channel activity and alters proteolytic ENaC activation. J Biol Chem 284, 29024-29030. PDF
(2) Krueger B, Haerteis S, Yang L, Hartner A, Rauh R, Korbmacher C, Diakov A (2009). Cholesterol depletion of the plasma membrane prevents activation of the epithelial sodium channel (ENaC) by SGK1. Cell Physiol Biochem 24, 605-618. PDF
(1) Svenningsen P, Bistrup C, Friis UG, Bertog M, Haerteis S, Krueger B, Stubbe J, Jensen OL, Thiesson HC, Uhrenholt TR, Jespersen B, Jensen BL, Korbmacher C, Skøtt O (2009). Plasmin in nephrotic urine activates the epithelial sodium channel.
J Am Soc Nephrol 20, 299-310. PDF
Dissertations
Erik Pion, Dr. med. 2023 | Etablierung eines In-vivo-Tumorangiogenese-Modells als Plattform für die Testung von personalisierten Therapien für Weichgewebesarkome |
Eva Bichlmayer, Dr. med. dent., 2023 | Untersuchung des Wachstums von humanem Nierenzysten-gewebe und von Mausnierenschnitten im 3D-in-ovo-Modell |
Milena Pejkovic, Dr. med. dent., 2022 | Retrospektive Analyse eines bei humanitären Hilfseinsätzen in Myanmar operierten Lippen-Kiefer-Gaumenspalten-Patientenkollektivs |
| Paulina Mena Kuri, Dr. med. dent., 2023 | Deep Learning-Based Image Analysis for the Quantification of Tumor-Induced Angiogenesis in the 3D In Vivo Tumor Model – Establishment and Addition to Laser Speckle Contrast Imaging (LSCI) |
| Johannes Tröbs, Dr. med. 2024 | 3D monitoring of tumor volume in an in vivo model |
Bachelor-/Master theses
| Sandra Maurer, Biologie, 2024 | Masterarbeit: Role of Connexins during wound healing in the human skin in the 3D-in-vivo model |
| Laura Lemberger, Biologie, 2024 | Masterarbeit: Evaluation of histopathological markers of the pancreatic ductal adenocarcinoma in QuPath |
| Jonas Künzel, Biologie, 2023 | Bachelorarbeit: Monitoring of patient tissue in the CAM model using ultra high frequency ultrasound |
| Sophia Hupp, Biologie, 2023 | Bachelorarbeit: Effects of Punicalagin on Osteosarcoma Cell Lines Including Evaluation of an Al-assisted Analysis |
| Lina Mahl, Molecular Medicine, 2021 | Bachelor thesis: Untersuchung des Wachstums von Tumoren und Zysten im 3D-in-vivo-Modell mittels (Mikro-) Computertomographie |
| Teresa Preiss, Molecular Medicine, 2020 | Bachelor thesis: Untersuchung von Mauszelllinien mit polyzystischer Nierenerkrankung im 3D-in vivo-Modell |
Magdalena Lippert, Molecular Medicine, 2019 | Bachelor thesis: Generierung eines Pkhd1::cre; Pkd2lox/lox; TrpV4-/-Doppelknockout Mausmodells zur Untersuchung des Einflusses von TRPV4 auf die Zystenbildung bei autosomal dominanter polyzystischer Nie-renerkrankung (ADPKD) |
Anita Hecht - 04.09.2024 14:40 
