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Publications

Fakultät für Biologie und Vorklinische Medizin
Institute für Anatomie
Regulation of Extracellular Matrix

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Publications

2017

  1. Kugler M, Schlecht A, Fuchshofer R, Schmitt SI, Kleiter I, Aigner L, Tamm ER, Braunger BM (2017) SMAD7 deficiency stimulates Müller progenitor cell proliferation during the development of the mammalian retina. Histochem Cell Biol. doi: 10.1007/s00418-017-1549-5 (Pubmed)

2016

  1. Reichhart N, Haase N, Crespo-Garcia S, Skosyrski S, Herrspiegel C, Kociok N, Fuchshofer R, Dillinger A, Poglitsch M, Müller DN, Joussen AM, Luft FC, Dechend R, Strauß O (2016) Hypertensive retinopathy in a transgenic angiotensin-based model. DOI: 10.1042/CS20160092 (Pubmed)

  2. Hennig R, Kuespert S, Haunberger A, Goepferich A, Fuchshofer R. (2016) Cyclic RGD peptides target human trabecular meshwork cells while ameliorating connective tissue growth factor-induced fibrosis. J Drug Target. 27:1-8. DOI: 10.3109/1061186X.2016.1163709 (Pubmed)

  3.  

    Schneider M, Fuchshofer R (2016) The role of astrocytes in optic nerve head fibrosis in glaucoma.Exp Eye Res. 2016 Jan;142:49-55. doi: 10.1016/j.exer.2015.08.014. (Pubmed)

2015

  1. Friedrich U, Datta S, Schubert T, Plössl K, Schneider M, Grassmann F, Fuchshofer R, Tiefenbach KJ, Längst G, Weber BH (2015) Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling. Hum Mol Genet.  15;24(22):6361-73. doi: 10.1093/hmg/ddv346. (Pubmed)

  2. Tamm ER, Braunger BM, Fuchshofer R (2015) Intraocular Pressure and the Mechanisms Involved in Resistance of the Aqueous Humor Flow in the Trabecular Meshwork Outflow Pathways. Prog Mol Biol Transl Sci. 134:301-14. doi: 10.1016/bs.pmbts.2015.06.007. (Pubmed)

  3. Kugler M, Schlecht A, Fuchshofer R, Kleiter I, Aigner L, Tamm ER, Braunger BM. (2015) Heterozygous modulation of TGF-β signaling does not influence Müller glia cell reactivity or proliferation following NMDA-induced damage. Histochem Cell Biol. 144(5):443-55. doi: 10.1007/s00418-015-1354-y. (Pubmed)

  4. Braunger BM, Fuchshofer R, Tamm ER (2015) The aqueous humor outflow pathways in glaucoma: A unifying concept of disease mechanisms and causative treatment. Eur J Pharm Biopharm. 95(Pt B):173-81. doi: 10.1016/j.ejpb.2015.04.029. (Pubmed)

  5. Kuespert S, Junglas B, Braunger BM, Tamm ER, Fuchshofer R  (2015) The regulation of connective tissue growth factor expression influences the viability of human trabecular meshwork cells. J Cell Mol Med. (Pubmed) 

2014

  1.  

     Braunger BM, Ademoglu B, Koschade SE, Fuchshofer R, Gabelt BT, Kiland JA, Hennes-Beann EA, Brunner KG, Kaufman PL, Tamm ER (2014) Identification of adult stem cells in Schwalbe's line region of the primate eye. Invest Ophthalmol Vis Sci. Oct 16;55(11):7499-507. (Pubmed)

     

  2.  

    Gallenberger M, Kroeber M, März L, Koch M, Fuchshofer R, Braunger BM, Iwata T, Tamm ER. (2014) Heterozygote Wdr36-deficient mice do not develop glaucoma. Exp Eye Res. 128:83-91. (Pubmed)

     

  3. Overby DR, Zhou EH, Vargas-Pinto R, Pedrigi RM, Fuchshofer R, Braakman ST, Gupta R, Perkumas KM, Sherwood JM, Vahabikashi A, Dang Q, Kim JH, Ethier CR, Stamer WD, Fredberg JJ, Johnson M. (2014) Altered mechanobiology of Schlemm's canal endothelial cells in glaucoma. Proc Natl Acad Sci. 111(38):13876-81. (Pubmed)

  4. Sippl C, Zeilbeck LF, Fuchshofer R, Tamm ER. (2014) Optineurin associates with the podocyte Golgi complex to maintain its structure. Cell Tissue Res. 358(2):567-83. (Pubmed)

  5. Fuchshofer R, Kuespert S, Junglas B, Tamm ER. (2014) The prostaglandin f2α analog fluprostenol attenuates the fibrotic effects of connective tissue growth factor on human trabecular meshwork cells. J Ocul Pharmacol Ther. 30(2-3):237-45. (Pubmed)

2013

  1. Pollinger K, Hennig R, Ohlmann A, Fuchshofer R, Wenzel R, Breunig M, Tessmar J, Tamm ER, Goepferich A. (2013) Ligand-functionalized nanoparticles target endothelial cells in retinal capillaries after systemic application. Proc Natl Acad Sci. 110(15):6115-20. (Pubmed)

2012

  1. Herrnberger L, Seitz R, Kuespert S, Bösl MR, Fuchshofer R, Tamm ER. (2012) Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice. Histochem Cell Biol. 138(5):709-24. (Pubmed)

  2. Junglas B,  Kuespert S, Seleem AA, Struller T, Bösl M, Bosserhoff A, Köstler J, Wagner R, Tamm ER, Fuchshofer R (2012) Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork. American Journal of Pathology 180(6):2386-403. (Pubmed)

  3. Fuchshofer R, Tamm ER (2012) The role of TGF-β in the pathogenesis of primary openangle glaucoma. Cell Tissue Res. 347(1):279-90. (Pubmed)

2011

  1. Fuchshofer R, Tamm ER. (2011) The role of TGF-β in the pathogenesis of primary open-angle glaucoma. Cell Tissue Res. 347(1):279-90. doi: 10.1007/s00441-011-1274-7. (Pubmed)

  2. Fuchshofer R, Ullmann S, Zeilbeck L, Baumann M, Junglas B, Tamm ER. (2011) Connective tissue growth factor modulates podocyte actin cytoskeleton and extracellular matrix synthesis and is induced in podocytes upon injury. Histochem Cell Biol. Sep;136(3):301-19. (Pubmed)

  3. Braig S, Wallner S, Junglas B, Fuchshofer R, Bosserhoff AK. (2011) CTGF is overexpressed in malignant melanoma and promotes cell invasion and migration. Br J Cancer.105(2):231-8. (Pubmed)

  4. Kritzenberger M, Junglas B, Framme C, Helbig H, Gabel VP, Fuchshofer R, Tamm ER, Hillenkamp J. (2011) Different collagen types define two types of idiopathic epiretinal membranes. Histopathology. 58(6):953-65. (Pubmed)

  5. Fuchshofer R, Kottler UB, Ohlmann AV, Schlötzer-Schrehardt U, Jünemann A, Kruse FE, Ohlmann A. (2011), SPARC is expressed in scars of the Tenon's capsule and mediates scarring properties of human Tenon's fibroblasts in vitro. Mol Vis. 17:177-85. (Pubmed)

  6. Bohr DC, Koch M, Kritzenberger M, Fuchshofer R, Tamm ER (2011), Increased expression of olfactomedin-1 and myocilin in podocytes during puromycin aminonucleoside nephrosis. Nephrology Dialysis Transplantation. 26(1):83-92. (Pubmed)

  7. Fuchshofer R (2011) The pathogenic role of transforming growth factor-β2 in glaucomatous damage to the optic nerve head, Exp Eye Res. 93(2):165-9. (Pubmed)

2010

  1. Karlstetter M, Walczak Y, Weigelt K, Ebert S, Van den Brulle J, Schwer H, Fuchshofer R, Langmann T. (2010) The novel activated microglia/macrophage WAP domain protein, AMWAP, acts as a counter-regulator of proinflammatory response, J Immunol. 185(6):3379-90.(Pubmed)

  2. Fuchshofer R. (2010) The pathogenic role of transforming growth factor-β2 in glaucomatous damage to the optic nerve head. Exp Eye Res. 93(2):165-9. doi: 10.1016/j.exer.2010.07.014. (Pubmed)

  3. Dirscherl K, Karlstetter M, Ebert S, Kraus D, Hlawatsch J, Walczak Y, Moehle C, Fuchshofer R, Langmann T. (2010) Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype, J Neuroinflammation. 14;7(1):3. (Pubmed)

2009

  1. Junglas B, Yu A.L., Welge-Lüssen U., Tamm ER. Fuchshofer R. (2009) Connective tissue growth factor induces extracellular matrix deposition in human trabecular meshwork cells, Exp. Eye. Res. 88(6):1065-75. (Pubmed)

  2. Fuchshofer R, Stephan DA, Russel P, Tamm ER. (2009) Gene expression profiling of TGFβ2- and/or BMP7-treated trabecular meshwork cells: Identification of Smad7 as a critical inhibitor of TGF-β2 signaling, Exp Eye Res. 88(6):1020-32. (Pubmed)

  3. Fuchshofer R, Tamm ER. Modulation of extracellular matrix turnover in the trabecular meshwork. Exp Eye Res. 88(4):683-8. (Pubmed)

  4. Yu AL, Fuchshofer R, Kook D, Kampik A, Bloemendal H, Welge-Lüssen U. (2009) Subtoxic oxidative stress induces senescence in retinal pigment epithelial cells via TGF-beta release. Invest Ophthalmol Vis Sci. 50(2):926-35. (Pubmed)

  5. Yu AL, Moriniere J, Birke M, Neumann C, Fuchshofer R, Kampik A, Bloemendal H, Welge-Lussen U. (2009) Reactivation of optic nerve head astrocytes by transforming growth factor-beta2 and hydrogen peroxide is accompanied by increased heat shock protein 32 and 47 expression. Invest Ophthalmol Vis Sci. 50(4):1707-17. (Pubmed)

  6. Fuchshofer R, Tamm ER (2009) Modulation of extracellular matrix turnover in the trabecular meshwork. Exp Eye Res. 88(4):683-8. (Pubmed)

2008

  1. Fuchshofer R, Yu AL, Welge-Lüssen U. (2008) Hypoxia and Reoxygenation induce CTGF and PAI-1 in cultured human retinal pigment epithelium cells. Exp Eye Res. 88(5):889-99. (Pubmed)

  2. Yu AL, Fuchshofer R, Kampik A, Welge-Lüssen U. (2008). Effects of oxidative stress in trabecular meshwork cells are reduced by prostaglandin analogues. Invest Ophthalmol Vis Sci. 49: 4872-80. (Pubmed)

  3. Paper W, Kroeber M, Heersink S, Stephan DA, Fuchshofer R, Russell P, Tamm ER (2008) Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression. Exp Eye Res.87: 257-67. (Pubmed)

  4. Yu AL, Fuchshofer R, Birke M, Kampik A, Bloemendal H, Welge-Lüssen U. (2008) Oxidative stress and TGF-beta2 increase heat shock protein 27 expression in human optic nerve head astrocytes. Invest Ophthalmol Vis Sci.  49: 5403-11. (Pubmed)

  5. Wurm A, Sock E, Fuchshofer R, Wegner M, Tamm ER. (2008) Anterior segment dysgenesis in the eyes of mice deficient for the high-mobility-group transcription factor Sox11. Exp. Eye Res. 86:895-907.(Pubmed)

  6. Tamm ER, Fuchshofer R.What increases outflow resistance in primary open-angle glaucoma? Surv Ophthalmol. 52 Suppl 2:S101-4. (Pubmed)

2007

  1. Yu AL, Fuchshofer R, Birke M, Priglinger SG, Eibl KH, Kampik A, Bloemendal H, Welge-Lüssen U (2007). Hypoxia/reoxygenation and transforming growth factor-β increase αB-crystallin expression in human optic nerve head astrocytes. Exp. Eye Res., 84: 694-706. (Pubmed)

  2. Fuchshofer R, Welge-Lüssen U, Yu AL, Tamm ER (2007) BMP7, a natural antagonist of TGF-β2 in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 48, 715-26. (Pubmed)

  3. Tamm ER, Fuchshofer R. (2007) What increases outflow resistance in primary open-angle glaucoma?. Survey of Ophthalmology, 52 Suppl 2:S101-4. (Pubmed)

2006

  1. Fuchshofer R, Welge-Lüssen U, Lütjen-Drecoll E, Birke M., (2006). Biochemical and morphological analysis of basement membrane component expression in corneoscleral and cribriform human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 47: 794-801. (Pubmed)

2005

  1. Fuchshofer R, Birke M, Welge-Lüssen U, Kook D, Lütjen-Drecoll E., (2005). TGF-β2 modulated extracellular matrix component expression in cultured human optic nerve head astrocytes. Invest Ophthalmol Vis Sci. 46: 568-78.(Pubmed)

2004

  1. Flügel-Koch C, Ohlmann A, Fuchshofer R, Welge-Lüssen U, Tamm ER., (2004). Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-β1 and dexamethasone in vitro. Exp Eye Res.79, 649-663. (Pubmed)

2003

  1. Fuchshofer R, Welge-Lussen U, Lutjen-Drecoll E., (2003). The effect of TGF-β2 on human trabecular meshwork extracellular proteolytic system. Exp Eye Res. 77:757-765. (Pubmed)

Books

  1. Fuchshofer R: Regulation of Extracellular Matrix Turnover in the Aqueous Humor Outflow Pathways. In: Dartt DA, Besharse J. (Hrsg): Encyclopedia of the Eye - Four-Volume Set. Elsevier, chapt. 97. 2010

  2. Fuchshofer R: Innate Immunity of the Eye Glaucoma. In: Zierhut M, Paulsen F, Niederkorn J, Schraermeyer U: Innate Immunity and the Eye. JAYPEE, chapt. 18, pp. 210-217

Antje Zenker - 11.11.2021 09:25

  1. STARTSEITE UR

Prof. Dr. rer. nat. Rudolf Fuchshofer

Institut für Anatomie

Lehrstuhl für Humananatomie und Embryologie

 

Fuchshofer Rudolf Neu2 191x191

Phone:                                 (49) (0)941 943-2881

Fax:                                      (49) (0)941 943-2840

E-mail:  Rudolf.Fuchshofer@ur.de