PROFILE
Profile
Scientific career and academic education
| 2013 - | Professor (W2), Neurophysiology, Institute of Zoology, Regensburg University |
| 2011 – 2014 | BMBF research group leader, Neurobiology, Department Biology II, LMU, Munich (B. Grothe) |
| 2004 - 2011 | Research Assistant, Physiologisches Institut, LMU, Munich (A. Konnerth, B. Sutor) |
| 2000 - 2004 | Postdoc, USA, Cold Spring Harbor Laboratory (Z. F. Mainen and K. Svoboda) |
| 1999-2000 | Postdoc, MPI for medical research (B. Sakmann) |
| 1996 - 1999 | PhD Dissertation, MPI for medical research (B. Sakmann) and Faculty for Physics and Astronomy, Heidelberg |
| 1989 - 1996 | Diploma in Physics, Technical University, Munich |
Honors and grants
| 2022 | Speaker of DFG-FORschungsgruppe "Modulation in olfaction" |
| 2020- | Priority programme 2205 “Evolutionary Optimisation of Neuronal Processing”: Tandem project with Dr. Silke Sachse, MPI for chemical ecology Jena (DFG) |
| 2018- | GIF (German Israeli Foundation) grant with Jackie Schiller and Adi Mizrahi: "Mechanisms of plasticity in primary olfactory pathways" |
| 2018- | DFG project grant EG 135/6-1: “Imaging of olfactory network activity in a semi-intact nose brain preparation: Generation of spontaneous theta-oscillations in the olfactory bulb” |
| 2017- | DFG project grant EG 135/5-1 with Dr. Michael Lukas: "Vasopressinergic actions in the olfactory bulb: Substrates and impact on social odor processing" |
| 2016- | Project with Prof. Eugen Kerkhoff in DFG-GRK: "Neurobiology of Emotion Dysfunctions" (GRK 2174, speaker Prof. Inga Neumann) |
| 2014 | BayIntAn Grant (Bayerische Forschungsallianz) for collaboration with Prof. Mathias Dutschmann, Florey Institute, Australia |
| 2012-2015 | Priority programme 1392 “Integrative analysis of olfaction” : Tandem project with Dr. Jovica Ninkovic (DFG) |
| 2011-2019 | Independent Junior Research group: “Function of a reciprocal synapse” (BMBF) |
| 2011-2013 | Member of Young CAS (Center for Advanced Studies, LMU); Mentee in LMU-excellent Mentoring Program (Prof. Kirsten Jung) |
| 2009-2012 | Priority programme 1392 “Integrative analysis of olfaction” : Tandem project with Prof. Dr. Magdalena Götz (DFG) |
| 2009-2013 | Collaborative Research Center/SFB 870 “Assembly and Function of Neuronal Circuits in Sensory Processing”, Project (DFG) |
| 2009-2013 | Member of Munich Center for Neuroscience und Graduate School of Systemic Neuroscience (MCN-, GSN-LMU) |
| 2007- | Member of Steering Committee in Priority Program 1392 “Integrative Analysis of Olfaction” (DFG) |
| 2004-2007 | Collaborative Research Center/SFB 391 “Mechanisms of fast cell activation”: Project with Prof. Dr. A. Konnerth (DFG) |
| 2001-2003 | Emmy-Noether Postdoctoral fellowship (DFG) |
| 2001 | Schloessmann-Award “Optical methods in biology” (Max-Planck-Gesellschaft) |
| 1996-1999 | Member of the graduate college ‘Molekulare und Zelluläre Grundlagen der Neurobiologie’, Ruprecht-Karls-Universtität Heidelberg (DFG), 1996-1999 |
| 1989-1995 | Bayerisches Begabtenstipendium (Scholarship) |
Other activities
| 2023- | Member of the Senate ofRegensburg University |
| 2023- | Treasuress of the GermanNeuroscientific Society (NWG) |
| 2019-2023 | Speaker of the section "Cellular Neuroscience" of the German Neuroscientfic Society (NWG) |
| 2017 | Organisation of an international symposium “Neuronal Mechanisms of Odor-guided Behaviour” at Regensburg University, with Prof. Dr Joachim Ruther, Regensburg, Prof. Dr. Silke Sachse, MPI for chemical Ecology Jena, Prof. Dr. Ilona Grunwald-Kadow, TUM (Supported by Vielberth-Foundation and BMBF) |
| 2016 | Organisation of an international symposium at FENS Kopenhagen (Supported by DFG/SPP 1392) |
| 2014- | Co-Editor of Journal of Neurophysiology |
| 2012- | Director of MSc program "Experimental and Clinical Neurosciences“ , Regensburg University |
| 2013- | Coordinator of restructuring of MSc program „Experimental and Clinical Neurosciences“, Regensburg University |
| 2013 | Organisation of an international symposium “Inhibition in olfaction“, CAS LMU Munich, with Dr. Silke Sachse, MPI for chemical Ecology Jena (Supported by CAS and DFG/SPP 1392) |
Papers
Publications - original papers
Preprints
Original papers
Jammal, L., Bitzenhofer, S.H., Hanganu-Opatz, I., Dutschmann, M. and Egger, V. (2023) Blood pressure pulsations modulate olfactory bulb neuronal activity via mechanosensitive ion channels
BioRxiv https://doi.org/10.1101/2023.07.27.550787
Jammal Salameh, L., Bitzenhofer, S.H., Hanganu-Opatz, I.,Dutschmann, M. and Egger, V. (2024) Bloodpressure pulsations modulate olfactory bulb neuronal activity viamechanosensitive ion channels. Science.
https://www.science.org/doi/10.1126/science.adk8511
Aghvami S.S., Kubota Y., and Egger V.(2022) Anatomical and FunctionalConnectivity at the Dendrodendritic Reciprocal MitralCell–Granule Cell Synapse: Impact on Recurrent and LateralInhibition. Front. Neural Circuits.
https://doi.org/10.3389/fncir.2022.933201
Suyama, H., Egger, V., and Lukas, M. (2021). Top-down acetylcholine signaling via olfactory bulb vasopressin cells contributes to social discrimination in rats. Communications Biology. doi:10.1038/s42003-021-02129-7
De Moura Oliveira, V.E., Lukas, M., Wolf, H.N., Durante, E., Lorenz, A., Mayer, A.-L., Bludau, A., Bosch, O.J., Grinevich, V., Egger, V., De Jong, T.R., and Neumann, I.D. (2021). Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats. Nature Communications. doi:10.1038/s41467-021-23064-5
Lage-Rupprecht V., Zhou L., Bianchini G., Aghvami S.S., Rozsa B., Sassoé-Pognetto M. & Egger V. (2020) Presynaptic NMDA receptors cooperate with local action potentials to implement activity-dependent GABA release from the reciprocal olfactory bulb granule cell spine. eLife 2020;9:e63737 doi: 10.7554/eLife.63737
Ona Jodar T*., Lage-Rupprecht V.*, Abraham N.M., Rose C.R. & Egger V. (2020) Local postsynaptic signalling on slow time scales in reciprocal olfactory bulb granule cell spines matches asynchronous release. Front Synaptic Neurosci 12:551691. doi: 10.3389/fnsyn.2020.551691. (*: shared first authors)
Mueller M. & Egger V. (2020) Dendritic integration in olfactory bulb granule cells: Threshold for lateral inhibition and role of active conductances upon simultaneous activation. PLOS Biology. doi.org/10.1371/journal.pbio.3000873
Lukas M., Suyama H. & Egger V. (2019) Vasopressin cells in the rodent olfactory bulb resemble non-bursting superficial tufted cells and are primarily inhibited upon olfactory nerve stimulation. eNeuro:ENEURO.0431-0418.2019. doi:10.1523/eneuro.0431-18.2019
Go M.A.*, Mueller M.*, Castanares M.L., Egger V.* & Daria V.* (2019) A compact holographic projector module for high-resolution 3D multi-site two-photon photostimulation. PLOS ONE doi: 10.1371/journal.pone.0210564 (*: shared first and last authorships)
Aghvami S., Müller M., Araabi B.N. & Egger V. (2019) Coincidence detection within the excitable rat olfactory bulb granule cell spines. J. Neurosci. 39, 584-595. doi: 10.1523/JNEUROSCI.1798-18.2018
Wagner L., Pannicke T., Rupprecht V., Frommherz I., Volz C., Illes P., Hirrlinger J., Jägle H., Egger V., Haydon P.G., Pfrieger F.W. & Grosche A. (2017) Suppression of SNARE-dependent exocytosis in retinal glial cells and its effect on ischemia-induced neurodegeneration. GLIA doi: 10.1002/glia.23144
Ona-Jodar T., Gerkau N.J., Aghvami S.S., Rose C.R. & Egger V. (2017) Two-photon Na+ imaging reports somatically-evoked action potentials in rat olfactory bulb mitral and granule cell neurites. Frontiers in Cellular Neuroscience 11 doi: 10.3389/fncel.2017.00050
Bywalez W., Ona-Jodar T., Lukas M., Ninkovic J. & Egger V. (2016) Dendritic arborization patterns of small juxtaglomerular cell subtypes within the rodent olfactory bulb. Frontiers in Neuroanatomy 10 doi:10.3389/fnana.2016.00127
Pérez de los Cobos Pallarés F., Bautista T.G., Stanic D., Egger V. & Dutschmann M. (2016) Brainstem-mediated sniffing and respiratory modulation during odor stimulation. Respiratory Physiology & Neurobiology 233, 17-24
Chatterjee M., Pérez de los Cobos Pallarés F., Loebel A., Lukas M. & Egger V. (2016) Sniff-like patterned input results in long-term plasticity at the rat olfactory bulb and tufted cell to granule cell synapse. Neural Plasticity 16 doi:10.1155/2016/9124986
Pérez de los Cobos Pallarés F., Staníc D., Farmer D., Dutschmann M. & Egger V. (2015) An Arterially Perfused Nose-Olfactory Bulb Preparation in Rat. J. Neurophysiol. 114, 2033-2042 doi.org/10.1152/jn.01048.2014
Bywalez W.G., Patirniche D., Rupprecht V., Stemmler M., Herz A. V. M., Pálfi D., Rózsa B. & Egger V. (2015) Local postsynaptic voltage-gated sodium channel activation in dendritic spines of olfactory bulb granule cells. Neuron 85, 590-601
Rammes G., Gravius A., Ruitberg M., Wegener N., Chambon C., Stroka-Saidi K., Jeggo R., Staniaszek L., Spanswick D., O'Hare E., Palmer P., Kim E. M., Bywalez W. G., Egger V. & Parsons C.G. (2015) MRZ-99030 - a novel modulator of β-amyloid (Aβ) aggregation reverses Aβ oligoner-induced deficits in longterm potentiation (LTP) and cognitive performance in rodents. Neuropharmacology 92, 170-182
Stroh O., Freichel M., Kretz O., Birnbaumer L., Hartmann J. & Egger V. (2012) NMDA-receptor dependent synaptic activation of TRPC channels in the olfactory bulb. J. Neurosci. 32, 5737–5746
Abraham N.M., Egger V., Shimshek D.R., Renden R., Fukunaga I., Sprengel R., Seeburg P.H., Klugmann M., Margrie T.W., Schaefer A.T. & Kuner T. (2010) Synaptic inhibition in the olfactory bulb accelerates odor discrimination in mice. Neuron 65, 399-411
Egger V. & Stroh O. Calcium buffering in rodent olfactory bulb granule cells and mitral cells. J. Physiol. 587, 4467-4479 (2009)
Egger V. Synaptic spikes in olfactory bulb granule cells cause long-lasting depolarization and calcium entry. Eur. J. Neurosci. 27, 2066-2075 (2008)
Egger V., Nevian T. & Bruno R.M. Subcolumnar dendritic and axonal organization of spiny stellate and star pyramid neurons within a barrel in rat somatosensory cortex. Cerebral Cortex 18, 876-889 (2008)
Egger V. & Urban N.U. Dynamic connectivity in the mitral cell – granule cell microcircuit of the olfactory bulb. Sem. Cell. Dev. Biol. 17, 424-432 (2006)
Egger V., Svoboda K. & Mainen Z.F. Dendrodendritic synaptic signaling in olfactory bulb granule cells: Local spine boost and global low-threshold spike. J. Neurosci. 25, 3521-3530 (2005)
Egger V., Svoboda K. & Mainen Z.F. Mechanisms of lateral inhibition in the olfactory bulb: Efficiency and modulation of spike-evoked calcium influx into granule cells. J. Neurosci. 23, 7551-7559 (2003)
Lübke J., Egger V., Sakmann B. & Feldmeyer D. Columnar organization of synaptically coupled excitatory spiny neurons in layer 4 of the rat barrel cortex. J. Neurosci. 20, 5300-5311 (2000)
Egger V., Feldmeyer D. & Sakmann B. Coincidence detection and changes in synaptic efficacy in pairs of spiny layer 4 neurons of rat barrel cortex. Nature Neurosci. 2, 1098-1105 (1999)
Feldmeyer D., Egger V., Lübke J. & Sakmann B. Reliable synaptic connections between pairs of excitatory layer 4 neurons within a ‘barrel’ of rat somatosensory cortex. J. Physiol. 521, 169-190 (1999)
Footnote: Egger & Urban 2006 is a review but also contains an anatomical model of dendrodendritic connectivity in the olfactory bulb.
Reviews etc
REVIEWS, COMMENTS, BOOK CHAPTERs
*: corresponding author
Suyama, H., Egger, V. and Lukas, M. (2022) Mammalian social memory
relies on neuromodulation in the olfactory bulb. Neuroforum.
https://doi.org/10.1515/nf-2022-0004
Egger V.* & Kuner T. (2021) Olfactory bulb granule cells: specialized to link co-active glomerular columns for percept generation and discrimination of odors. In: Cell and Tissue Research Special Issue "Olfactory Coding and Circuitries", Springer. Sachse S, Manzini I (eds). 383(1):495-506. doi: 10.1007/s00441-020-03402-7.
Egger V.* & Diamond J.S. (2020) A17 amacrine cells and olfactory granule cells: parallel processors of early sensory information. Front. Cell. Neurosci. doi.org/10.3389/fncel.2020.600537
Egger V. (2018) Riechen Sehen. Blick in die Wissenschaft 37, 27-33 doi.org/10.5283/bidw.v27i37
Lukas M., Holthoff K., Egger V.* (2018) Long-Term Plasticity at the Mitral and Tufted Cell to Granule Cell Synapse of the Olfactory Bulb Investigated with a Custom Multielectrode in Acute Brain Slice Preparations. In: Olfactory Receptors: Methods and Protocols. Springer New York, New York, NY. Simoes de Souza FM, Antunes G (eds) doi:10.1007/978-1-4939-8609-5_13
Egger V.* & Feldmeyer D. (2013) Electrical activity of neurons. Buchkapitel für Neurosciences, Springer (Hrsg. C.G.Galizia & P.M.Lledo)
Egger V.* & Urban N.U. (2006) Dynamic connectivity in the mitral cell – granule cell microcircuit of the olfactory bulb. Sem. Cell. Dev. Biol. 17, 424-432
Egger V. (2007) Imaging the activity of neuronal populations: when spikes don’t flash and flashes don’t spike. Perspectives article. J. Physiol. 582, 7.
