Research
Research
In the last decades, the research field on RNAs developed dramatically and the role of different types of RNAs to pathologies became obvious. LncRNAs and other non-coding RNAs like circular RNAs and miRNAs are highly expressed in the brain and associated with a wide range of neurodevelopmental, neurodegenerative and psychiatric diseases. However, the involvement of non-coding RNAs, especially miRNAs and lncRNAs, in social fear and social fear extinction is still unknown.
In my project, I want to assess the involvement of coding and non-coding RNAs in SFC-induced social fear and its extinction. Therefore, I use the social fear condition paradigm to induce symptoms of social in fear in mice, and Total RNA Sequencing to determine involved RNAs. In this context, I also want to map a comprehensive path from OXTR activation to protein synthesis changes via pre- and post-transcriptional regulation through non-coding RNAs, resulting in altered behaviour of the animals. Used techniques include for example RNA/protein extraction, Next Generation Sequencing, social fear conditioning and behavioural tests, Western blots, qPCRs, immunohistochemistry, stereotactic implantations and intracerebral microdialysis.
Profile
Profile
Since 2017
PhD student in neurobiology/biochemistry in Prof. Dr. Inga D. Neumann’s/ Prof. Dr. Gunter Meister’s group, Department of Molecular and Behavioural Neurobiology/ Biochemistry I, University of Regensburg, Germany
at the University of Regensburg, Germany.
Funded project by the GRK2174 (DFG)
2014-2016
M.Sc. in Biology at the University of Regensburg with focus on Biochemistry, Human Molecular Biology/Anatomy and Human Genetics
Thesis: “Effects of Retinoschisin on Localization, Thermostability and Substrate Affinity of the Na/K-ATPase - Research in Pathological Processes in X-linked Juvenile Retinoschisis”, Prof. Dr. Bernhard Weber, Institute of Human Genetics, University of Regensburg, Germany
2011-2014
B.Sc. in Biology at the University of Regensburg
Thesis: “Dose-dependent effects of chronic oxytocin applications on anxiety-related behaviour and gene expression in rats”, Prof. Inga D. Neumann, Department of Molecular and Behavioural Neurobiology, University of Regensburg, Germany
Born September 1991, Burglengenfeld, Germany
Publications
Publications
Karolina Plössl, Melanie Royer, Sarah Bernklau, Neslihan N. Tavraz, Thomas Friedrich, Jens Wild, Bernhard H. F. Weber, and Ulrike Friedrich; 2017; Retinoschisin is linked to retinal Na/K-ATPase signaling and localization.; Molecular Biology of the CellVol. 28, No. 16
